{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:50:44Z","timestamp":1794243044147,"version":"4.9.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Ningbo Medical Science and Technology Plan","award":["2021Y69"],"award-info":[{"award-number":["2021Y69"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"DOI":"10.1186\/s12902-025-01927-y","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T04:44:11Z","timestamp":1745210651000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between triglyceride glucose index and depression in polycystic ovary syndrome"],"prefix":"10.1186","volume":"25","author":[{"given":"Guili","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"1927_CR1","doi-asserted-by":"crossref","unstructured":"Revised. 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction. 2004;19(1):41\u2013\u20097.","DOI":"10.1093\/humrep\/deh098"},{"issue":"12","key":"1927_CR2","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s11883-023-01168-1","volume":"25","author":"YR Alvarez","year":"2023","unstructured":"Alvarez YR, Pico M, Ashokprabhu N, Abou-Amro K, Bailey S, Pung E, et al. Polycystic ovarian syndrome: a risk factor for cardiovascular disease. Curr Atheroscler Rep. 2023;25(12):1003\u201311.","journal-title":"Curr Atheroscler Rep"},{"issue":"7","key":"1927_CR3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.tcm.2019.08.010","volume":"30","author":"O Osibogun","year":"2020","unstructured":"Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2020;30(7):399\u2013404.","journal-title":"Trends Cardiovasc Med"},{"issue":"4","key":"1927_CR4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.fertnstert.2023.07.025","volume":"120","author":"HJ Teede","year":"2023","unstructured":"Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 international Evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2023;120(4):767\u201393.","journal-title":"Fertil Steril"},{"issue":"5","key":"1927_CR5","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/humrep\/dex044","volume":"32","author":"LG Cooney","year":"2017","unstructured":"Cooney LG, Lee I, Sammel MD, Dokras A. High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2017;32(5):1075\u201391.","journal-title":"Hum Reprod"},{"key":"1927_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","volume":"34","author":"RCBE Kessler","year":"2013","unstructured":"Kessler RCBE. The epidemiology of depression across cultures. Annu Rev Public Health. 2013;34:119\u201338.","journal-title":"Annu Rev Public Health"},{"key":"1927_CR7","unstructured":"Depression. and Other common mental disorders, global health estimates. World Health Organization; 2017."},{"issue":"10312","key":"1927_CR8","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","volume":"398","author":"DF Santomauro","year":"2021","unstructured":"Santomauro DF, Mantilla Herrera AM, Shadid J, Zheng P, Ashbaugh C, Pigott DM, et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet. 2021;398(10312):1700\u201312.","journal-title":"Lancet"},{"issue":"9","key":"1927_CR9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","volume":"10","author":"E Anju","year":"2022","unstructured":"Anju E, Joham RJN, Elisabet Stener-Victorin RS, Legro S, Franks LJ, Moran. Jacqueline Boyle, Helena J Teede. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668\u201380.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"1927_CR10","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1161\/CIRCRESAHA.119.315896","volume":"126","author":"H Wu","year":"2020","unstructured":"Wu H, Ballantyne CM. Metabolic inflammation and insulin resistance in obesity. Circul Res. 2020;126(11):1549\u201364.","journal-title":"Circul Res"},{"key":"1927_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8609213","volume":"2020","author":"H Yaribeygi","year":"2020","unstructured":"Yaribeygi H, Sathyapalan T, Atkin SL, Sahebkar A. Molecular mechanisms linking oxidative stress and diabetes mellitus. Oxidative Med Cell Longev. 2020;2020:1\u201313.","journal-title":"Oxidative Med Cell Longev"},{"issue":"3","key":"1927_CR12","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1002\/jcp.27278","volume":"234","author":"H Yaribeygi","year":"2018","unstructured":"Yaribeygi H, Butler AE, Barreto GE, Sahebkar A. Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients. J Cell Physiol. 2018;234(3):2436\u201346.","journal-title":"J Cell Physiol"},{"key":"1927_CR13","doi-asserted-by":"crossref","unstructured":"Willmer T, Goedecke JH, Dias S, Louw J, Pheiffer C. DNA methylation of FKBP5 in South African women: associations with obesity and insulin resistance. Clin Epigenetics. 2020;12(1).","DOI":"10.1186\/s13148-020-00932-3"},{"key":"1927_CR14","doi-asserted-by":"publisher","first-page":"105582","DOI":"10.1016\/j.neubiorev.2024.105582","volume":"159","author":"AH Behnoush","year":"2024","unstructured":"Behnoush AH, Mousavi A, Ghondaghsaz E, Shojaei S, Cannavo A, Khalaji A. The importance of assessing the triglyceride-glucose index (TyG) in patients with depression: a systematic review. Neurosci Biobehav Rev. 2024;159:105582.","journal-title":"Neurosci Biobehav Rev"},{"key":"1927_CR15","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jad.2016.10.027","volume":"208","author":"J-H Lee","year":"2017","unstructured":"Lee J-H, Park SK, Ryoo J-H, Oh C-M, Mansur RB, Alfonsi JE, et al. The association between insulin resistance and depression in the Korean general population. J Affect Disord. 2017;208:553\u20139.","journal-title":"J Affect Disord"},{"issue":"2","key":"1927_CR16","doi-asserted-by":"publisher","first-page":"480","DOI":"10.2337\/dc12-1442","volume":"36","author":"CSN Kan","year":"2013","unstructured":"Kan CSN, Golden SH, Rajala U,Timonen M. A systematic review and meta-analysis of the association between depression and insulin resistance. Diabetes Care. 2013;36(2):480\u20139.","journal-title":"Diabetes Care"},{"issue":"12","key":"1927_CR17","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1016\/j.numecd.2022.07.024","volume":"32","author":"SA Nabipoorashrafi","year":"2022","unstructured":"Nabipoorashrafi SA, Seyedi SA, Rabizadeh S, Ebrahimi M, Ranjbar SA, Reyhan SK, et al. The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: A systematic review and meta-analysis. Nutr Metabolism Cardiovasc Dis. 2022;32(12):2677\u201388.","journal-title":"Nutr Metabolism Cardiovasc Dis"},{"key":"1927_CR18","doi-asserted-by":"crossref","unstructured":"Shi Y-Y, Zheng R, Cai J-J, Qian S-Z. The association between triglyceride glucose index and depression: data from NHANES 2005\u20132018. BMC Psychiatry. 2021;21(1).","DOI":"10.1186\/s12888-021-03275-2"},{"key":"1927_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jad.2017.02.002","volume":"213","author":"J Oh","year":"2017","unstructured":"Oh J, Kim T-S. Serum lipid levels in depression and suicidality: the Korea National health and nutrition examination survey (KNHANES) 2014. J Affect Disord. 2017;213:51\u20138.","journal-title":"J Affect Disord"},{"key":"1927_CR20","doi-asserted-by":"crossref","unstructured":"Xu Z-Y, Zheng H, Pan Z-J, Hu S-Y, Wang Y-X, Su W-J. Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: evidence from a large National cohort study. Biomolecules Biomed. 2025.","DOI":"10.17305\/bb.2024.11800"},{"issue":"3","key":"1927_CR21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/014662167700100306","volume":"1","author":"LS Radloff","year":"1977","unstructured":"Radloff LS, The CES-D, Scale A. Self-Report depression scale for research in the general population. Appl Psychol Meas. 1977;1(3):385\u2013401.","journal-title":"Appl Psychol Meas"},{"key":"1927_CR22","doi-asserted-by":"crossref","unstructured":"Li H, Zheng D, Li Z, Wu Z, Feng W, Cao X et al. Association of depressive symptoms with incident cardiovascular diseases in Middle-Aged and older Chinese adults. JAMA Netw Open. 2019;2(12).","DOI":"10.1001\/jamanetworkopen.2019.16591"},{"key":"1927_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fpsyt.2019.00315","volume":"10","author":"LWY Jiang","year":"2019","unstructured":"Jiang LWY, Zhang Y, Li R, Wu H. The reliability and validity of the center for epidemiologic studies depression scale (CES-D) for Chinese university students. Front Psychiatry. 2019;10:315.","journal-title":"Front Psychiatry"},{"key":"1927_CR24","doi-asserted-by":"crossref","unstructured":"Fu H, Si L, Guo R. What is the optimal Cut-Off point of the 10-Item center for epidemiologic studies depression scale for screening depression among Chinese individuals aged 45 and over?? An exploration using latent profile analysis. Front Psychiatry. 2022;13.","DOI":"10.3389\/fpsyt.2022.820777"},{"issue":"3\u20134","key":"1927_CR25","first-page":"203","volume":"27","author":"G Bayhan","year":"2000","unstructured":"Bayhan G, Demirkol MBT, Ertem,A M, Yalinkaya,A, C Erden. A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism. Clin Exp Obstet Gynecol. 2000;27(3\u20134):203\u20136.","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"11","key":"1927_CR26","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1111\/j.1468-3083.2011.04292.x","volume":"26","author":"L Colonna","year":"2011","unstructured":"Colonna L, Pacifico V, Lello S, Sorge R, Raskovic D, Primavera G. Skin improvement with two different oestroprogestins in patients affected by acne and polycystic ovary syndrome: clinical and instrumental evaluation. J Eur Acad Dermatol Venereol. 2011;26(11):1364\u201371.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1927_CR27","doi-asserted-by":"crossref","unstructured":"Handelsman DJ, Cong J, Li P, Zheng L, Tan J. Prevalence and risk factors of infertility at a rural site of Northern China. PLoS ONE. 2016;11(5).","DOI":"10.1371\/journal.pone.0155563"},{"key":"1927_CR28","doi-asserted-by":"publisher","first-page":"1131802","DOI":"10.3389\/fpsyt.2023.1131802","volume":"14","author":"LHJ Luo","year":"2023","unstructured":"Luo LHJ, Huang R, Kong D. The association between dietary inflammation index and depression. Front Psychiatry. 2023;14:1131802.","journal-title":"Front Psychiatry"},{"key":"1927_CR29","doi-asserted-by":"crossref","unstructured":"Liu C, Liang D. The association between the triglyceride\u2013glucose index and the risk of cardiovascular disease in US population aged\u2009\u2264\u200965 years with prediabetes or diabetes: a population-based study. Cardiovasc Diabetol. 2024;23(1).","DOI":"10.1186\/s12933-024-02261-8"},{"key":"1927_CR30","doi-asserted-by":"crossref","unstructured":"Hong Z, Wu P, Zhuang H, Chen L, Hong S, Qin J. Prevalence of depression among women with polycystic ovary syndrome in Mainland China: a systematic review and meta-analysis. BMC Psychiatry. 2024;24(1).","DOI":"10.1186\/s12888-024-06378-8"},{"issue":"09","key":"1927_CR31","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1017\/S0033291718002076","volume":"49","author":"AL Damone","year":"2018","unstructured":"Damone AL, Joham AE, Loxton D, Earnest A, Teede HJ, Moran LJ. Depression, anxiety and perceived stress in women with and without PCOS: a community-based study. Psychol Med. 2018;49(09):1510\u201320.","journal-title":"Psychol Med"},{"issue":"6","key":"1927_CR32","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1515\/ijamh-2021-0092","volume":"33","author":"M Zehravi","year":"2021","unstructured":"Zehravi M, Maqbool M, Ara I. Depression and anxiety in women with polycystic ovarian syndrome: a literature survey. Int J Adolesc Med Health. 2021;33(6):367\u201373.","journal-title":"Int J Adolesc Med Health"},{"issue":"1","key":"1927_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12933-020-01031-6","volume":"19","author":"K-W Nam","year":"2020","unstructured":"Nam K-W, Kwon H-M, Jeong H-Y, Park J-H, Kwon H, Jeong S-M. High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study. Cardiovasc Diabetol. 2020;19(1):53.","journal-title":"Cardiovasc Diabetol"},{"issue":"14","key":"1927_CR34","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1017\/S0033291720000951","volume":"51","author":"H-C So","year":"2020","unstructured":"So H-C, Chau CK-l, Cheng Y-y, Sham PC. Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis. Psychol Med. 2020;51(14):2357\u201369.","journal-title":"Psychol Med"},{"key":"1927_CR35","doi-asserted-by":"crossref","unstructured":"Hoare E, Dash S, Varsamis P, Jennings G, Kingwell B. Fasting plasma glucose, Self-Appraised diet quality and depressive symptoms: A US-Representative Cross-Sectional study. Nutrients. 2017;9(12).","DOI":"10.3390\/nu9121330"},{"key":"1927_CR36","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.2147\/NDT.S484745","volume":"20","author":"J Guan","year":"2024","unstructured":"Guan J, Wang Y, Dong C, Chen Y, Li B, Zhou Y, et al. The impact of the Triglyceride-Glucose index on the development of depression in patients with coronary atherosclerotic heart disease. Neuropsychiatr Dis Treat. 2024;20:2105\u201313.","journal-title":"Neuropsychiatr Dis Treat"},{"key":"1927_CR37","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jad.2019.02.049","volume":"249","author":"J-K Ko","year":"2019","unstructured":"Ko J-K, Han K-M, Shin C, Lee S-H, Han C, Kim Y-K, et al. Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population. J Affect Disord. 2019;249:319\u201326.","journal-title":"J Affect Disord"},{"key":"1927_CR38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jad.2020.09.073","volume":"278","author":"JW Lee","year":"2021","unstructured":"Lee JW, Park SH. Association between depression and nonalcoholic fatty liver disease: contributions of insulin resistance and inflammation. J Affect Disord. 2021;278:259\u201363.","journal-title":"J Affect Disord"},{"issue":"2","key":"1927_CR39","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/jch.14767","volume":"26","author":"X Zhang","year":"2024","unstructured":"Zhang X, Zhao D, Guo S, Yang J, Liu Y. Association between triglyceride glucose index and depression in hypertensive population. J Clin Hypertens. 2024;26(2):177\u201386.","journal-title":"J Clin Hypertens"},{"key":"1927_CR40","doi-asserted-by":"crossref","unstructured":"Rawlinson S, Andrews ZB. Hypothalamic insulin signalling as a nexus regulating mood and metabolism. J Neuroendocrinol. 2021;33(4).","DOI":"10.1111\/jne.12939"},{"key":"1927_CR41","doi-asserted-by":"crossref","unstructured":"Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proceedings of the National Academy of Sciences. 2015;112(11):3463-8.","DOI":"10.1073\/pnas.1500877112"},{"issue":"1","key":"1927_CR42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1080\/09513590.2018.1498476","volume":"35","author":"HNM Erensoy","year":"2019","unstructured":"Erensoy HNM, Ghafarzadeh S, Aghamohammadzadeh N, Nader ND. A pilot trial of Metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome. Gynecol Endocrinol. 2019;35(1):72\u20135.","journal-title":"Gynecol Endocrinol"},{"issue":"9","key":"1927_CR43","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/pcn.13433","volume":"76","author":"MH HMCYC","year":"2022","unstructured":"MH HMCYC. Pro-inflammatory cytokines and cognitive dysfunction among patients with bipolar disorder and major depression. Psychiatry Clin Neurosci. 2022;76(9):450\u20138.","journal-title":"Psychiatry Clin Neurosci"},{"key":"1927_CR44","doi-asserted-by":"crossref","unstructured":"Ryan KM, McLoughlin DM. Peripheral blood inflammatory markers in depression: response to electroconvulsive therapy and relationship with cognitive performance. Psychiatry Res. 2022;315.","DOI":"10.1016\/j.psychres.2022.114725"},{"issue":"2","key":"1927_CR45","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s00125-020-05301-6","volume":"64","author":"AL Carr","year":"2020","unstructured":"Carr AL, Sluiman AJ, Grecian SM, Forster R, McLachlan S, Strachan MWJ, et al. Depression as a risk factor for dementia in older people with type 2 diabetes and the mediating effect of inflammation. Diabetologia. 2020;64(2):448\u201357.","journal-title":"Diabetologia"},{"key":"1927_CR46","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.actbio.2023.09.038","volume":"171","author":"LLM Liu","year":"2023","unstructured":"Liu LLM, Xiu J, Zhang B,Hu H. Stimuli-responsive nanoparticles delivered by a nasal-brain pathway alleviate depression-like behavior through extensively scavenging ROS. Acta Biomater. 2023;171:451\u201365.","journal-title":"Acta Biomater"},{"issue":"6","key":"1927_CR47","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.2174\/1570159X19666211111141246","volume":"20","author":"W Hassan","year":"2022","unstructured":"Hassan W, Noreen H, Rehman S, Kamal MA, da Rocha JBT. Association of oxidative stress with neurological disorders. Curr Neuropharmacol. 2022;20(6):1046\u201372.","journal-title":"Curr Neuropharmacol"},{"issue":"7","key":"1927_CR48","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.drudis.2020.05.001","volume":"25","author":"S Bhatt","year":"2020","unstructured":"Bhatt S, Nagappa AN, Patil CR. Role of oxidative stress in depression. Drug Discovery Today. 2020;25(7):1270\u20136.","journal-title":"Drug Discovery Today"},{"key":"1927_CR49","doi-asserted-by":"crossref","unstructured":"Chen H, Lu M, Lyu Q, Shi L, Zhou C, Li M et al. Mitochondrial dynamics dysfunction: unraveling the hidden link to depression. Biomed Pharmacother. 2024;175.","DOI":"10.1016\/j.biopha.2024.116656"},{"key":"1927_CR50","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.pnpbp.2017.06.036","volume":"80","author":"P Czarny","year":"2018","unstructured":"Czarny P, Wigner P, Galecki P, Sliwinski T. The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2018;80:309\u201321.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1927_CR51","doi-asserted-by":"crossref","unstructured":"Tobe E. Mitochondrial dysfunction, oxidative stress, and major depressive disorder. Neuropsychiatr Dis Treat. 2013.","DOI":"10.2147\/NDT.S44282"},{"key":"1927_CR52","doi-asserted-by":"publisher","first-page":"108","DOI":"10.2174\/1570159X11666131120231448","volume":"12","author":"CW Ying Xu","year":"2014","unstructured":"Ying Xu CW, Jonathan J, Klabnik JM, O\u2019Donnell. Novel therapeutic targets in depression and anxiety antioxidants as a candidate treatment. Curr Neuropharmacol. 2014;12:108\u201319.","journal-title":"Curr Neuropharmacol"},{"key":"1927_CR53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/jcm13133941","volume":"13","author":"B Adams-Huet","year":"2024","unstructured":"Adams-Huet B, Jialal I. An increasing Triglyceride\u2013Glucose index is associated with a Pro-Inflammatory and Pro-Oxidant phenotype. J Clin Med. 2024;13:13.","journal-title":"J Clin Med"},{"key":"1927_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8067045","volume":"2019","author":"M Luca","year":"2019","unstructured":"Luca M, Luca A. Oxidative Stress-Related endothelial damage in vascular depression and vascular cognitive impairment: beneficial effects of aerobic physical exercise. Oxidative Med Cell Longev. 2019;2019:1\u20136.","journal-title":"Oxidative Med Cell Longev"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-025-01927-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-025-01927-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-025-01927-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T04:44:24Z","timestamp":1745210664000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-025-01927-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1927"],"URL":"https:\/\/doi.org\/10.1186\/s12902-025-01927-y","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"1 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Yuyao People\u2019s Hospital (protocol code: 2022-03-014), and informed consent was obtained from participants. The Protocol of the current study was performed in accordance with the Declaration of Helsinki standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The online version contains supplementary material available at .","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Supplementary information"}}],"article-number":"108"}}