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Informed consent was obtained from all individual participants included in the study. The study has been approved for execution by the ethics committees of the Affiliated Guangzhou Red Cross Hospital of Jinan University, Guangdong Second Provincial General Hospital, Zhujiang Hospital of Southern Medical University, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou First People\u2019s Hospital, and the Affiliated TCM Hospital of Guangzhou Medical University and adhered to the ethical guidelines of the Helsinki Declaration. 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