{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:32:58Z","timestamp":1787020378750,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Chongqing Science and Health","award":["2021ZY3617"],"award-info":[{"award-number":["2021ZY3617"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"DOI":"10.1186\/s12902-026-02238-6","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:28:50Z","timestamp":1774952930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of alpha-lipoic acid supplementation on patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of randomized clinical trials"],"prefix":"10.1186","volume":"26","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"1","key":"2238_CR1","doi-asserted-by":"publisher","first-page":"e182","DOI":"10.1017\/S1368980024001149","volume":"27","author":"A Motamedi","year":"2024","unstructured":"Motamedi A, Alizadeh S, Osati S, Raeisi T, Homayounfar R. Dietary insulin index and dietary insulin load in relation to non-alcoholic fatty liver disease: a cross-sectional study. Public Health Nutr. 2024;27(1):e182.","journal-title":"Public Health Nutr"},{"issue":"3","key":"2238_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5812\/ircmj.65925","volume":"20","author":"F Amirkhizi","year":"2018","unstructured":"Amirkhizi F, Hamedi-Shahraki S, Hosseinpour-Arjmand S, Ebrahimi-Mameghani M. The effect of alpha-lipoic acid on liver function and metabolic markers in obese patients with non-alcoholic fatty liver disease: a double-blind randomized controlled trial. Iran Red Crescent Med J. 2018;20(3):1\u201311.","journal-title":"Iran Red Crescent Med J"},{"issue":"9","key":"2238_CR3","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","volume":"7","author":"K Riazi","year":"2022","unstructured":"Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. lancet Gastroenterol Hepatol. 2022;7(9):851\u201361.","journal-title":"lancet Gastroenterol Hepatol"},{"issue":"5","key":"2238_CR4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.dld.2010.01.016","volume":"42","author":"E Vanni","year":"2010","unstructured":"Vanni E, Bugianesi E, Kotronen A, De Minicis S, Yki-J\u00e4rvinen H, Svegliati-Baroni G. From the metabolic syndrome to NAFLD or vice versa? Dig liver Disease. 2010;42(5):320\u201330.","journal-title":"Dig liver Disease"},{"key":"2238_CR5","doi-asserted-by":"crossref","unstructured":"Kim DY, Park JY. Genetic risk factors associated with NAFLD. Hepatoma Research. 2020;6.","DOI":"10.20517\/2394-5079.2020.96"},{"issue":"11","key":"2238_CR6","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3109\/10715762.2013.837577","volume":"47","author":"Y Sumida","year":"2013","unstructured":"Sumida Y, Niki E, Naito Y, Yoshikawa T. Involvement of free radicals and oxidative stress in NAFLD\/NASH. Free Radic Res. 2013;47(11):869\u201380.","journal-title":"Free Radic Res"},{"issue":"5","key":"2238_CR7","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.3390\/ijms22052350","volume":"22","author":"A Mantovani","year":"2021","unstructured":"Mantovani A, Dalbeni A. Treatments for NAFLD: state of art. Int J Mol Sci. 2021;22(5):2350.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2238_CR8","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jhepr.2019.10.008","volume":"1","author":"K Hallsworth","year":"2019","unstructured":"Hallsworth K, Adams LA. Lifestyle modification in NAFLD\/NASH: facts and figures. JHEP Rep. 2019;1(6):468\u201379.","journal-title":"JHEP Rep"},{"issue":"10","key":"2238_CR9","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.tem.2019.07.013","volume":"30","author":"NN El-Agroudy","year":"2019","unstructured":"El-Agroudy NN, Kurzbach A, Rodionov RN, O\u2019Sullivan J, Roden M, Birkenfeld AL, Pesta DH. Are lifestyle therapies effective for NAFLD treatment? Trends Endocrinol Metabolism. 2019;30(10):701\u20139.","journal-title":"Trends Endocrinol Metabolism"},{"issue":"2","key":"2238_CR10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s43450-023-00370-1","volume":"33","author":"AK Tripathi","year":"2023","unstructured":"Tripathi AK, Ray AK, Mishra SK, Bishen SM, Mishra H, Khurana A. Molecular and therapeutic insights of alpha-lipoic acid as a potential molecule for disease prevention. Revista brasileira de farmacognosia. 2023;33(2):272\u201387.","journal-title":"Revista brasileira de farmacognosia"},{"issue":"20","key":"2238_CR11","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.1074\/jbc.TM117.000259","volume":"293","author":"A Solmonson","year":"2018","unstructured":"Solmonson A, DeBerardinis RJ. Lipoic acid metabolism and mitochondrial redox regulation. J Biol Chem. 2018;293(20):7522\u201330.","journal-title":"J Biol Chem"},{"issue":"5","key":"2238_CR12","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1002\/fsn3.2235","volume":"9","author":"CY Ko","year":"2021","unstructured":"Ko CY, Lo YM, Xu JH, Chang WC, Huang DW, Wu JSB, et al. Alpha-lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats. Food Sci Nutr. 2021;9(5):2733\u201342.","journal-title":"Food Sci Nutr"},{"issue":"2","key":"2238_CR13","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1089\/jmf.2013.0111","volume":"17","author":"MN Stankovi\u0107","year":"2014","unstructured":"Stankovi\u0107 MN, Mladenovi\u0107 D, Ninkovi\u0107 M, \u00d0uri\u010di\u0107 I, \u0160obaji\u0107 S, Jorga\u010devi\u0107 B, et al. The effects of \u03b1-lipoic acid on liver oxidative stress and free fatty acid composition in methionine\u2013choline deficient diet-induced NAFLD. J Med Food. 2014;17(2):254\u201361.","journal-title":"J Med Food"},{"issue":"2","key":"2238_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/jcpt.12784","volume":"44","author":"S Hosseinpour-Arjmand","year":"2019","unstructured":"Hosseinpour-Arjmand S, Amirkhizi F, Ebrahimi\u2010Mameghani M. The effect of alpha\u2010lipoic acid on inflammatory markers and body composition in obese patients with non\u2010alcoholic fatty liver disease: A randomized, double\u2010blind, placebo\u2010controlled trial. J Clin Pharm Ther. 2019;44(2):258\u201367.","journal-title":"J Clin Pharm Ther"},{"issue":"1","key":"2238_CR15","doi-asserted-by":"publisher","first-page":"2341701","DOI":"10.1080\/09513590.2024.2341701","volume":"40","author":"AD Genazzani","year":"2024","unstructured":"Genazzani AD, Battipaglia C, Rusce L, Prampolini G, Aio C, Ricciardiello F, et al. Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight\/obese PCOS patients. Gynecol Endocrinol. 2024;40(1):2341701.","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"2238_CR16","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/obr.12528","volume":"18","author":"S Kucukgoncu","year":"2017","unstructured":"Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta\u2010analysis of randomized controlled trials. Obes Rev. 2017;18(5):594\u2013601.","journal-title":"Obes Rev"},{"key":"2238_CR17","doi-asserted-by":"publisher","first-page":"106050","DOI":"10.1016\/j.jff.2024.106050","volume":"114","author":"M Ebrahimi-Mameghani","year":"2024","unstructured":"Ebrahimi-Mameghani M, Asghari S, Naeini F, Taghizadeh M, Hamedi-Shahraki S, Amirkhizi F. Assessing the clinical and biochemical efficacy of alpha-lipoic acid in patients with non-alcoholic fatty liver disease: A randomized placebo-controlled clinical trial. J Funct Foods. 2024;114:106050.","journal-title":"J Funct Foods"},{"issue":"5","key":"2238_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4236\/ojgas.2014.45030","volume":"4","author":"PP Basu","year":"2014","unstructured":"Basu PP, Shah NJ, Aloysius MM, Brown RS Jr. Effect of vitamin E and alpha lipoic acid in nonalcoholic fatty liver disease: a randomized, placebo-controlled, open-label, prospective clinical trial (VAIN trial). Open J Gastroenterol. 2014;4(5):199\u2013207.","journal-title":"Open J Gastroenterol"},{"key":"2238_CR19","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.clnesp.2023.02.016","volume":"54","author":"H Tutunchi","year":"2023","unstructured":"Tutunchi H, Arefhosseini S, Ebrahimi-Mameghani M. Clinical effectiveness of \u03b1-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial. Clin Nutr ESPEN. 2023;54:412\u201320.","journal-title":"Clin Nutr ESPEN"},{"key":"2238_CR20","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372.","DOI":"10.1136\/bmj.n71"},{"issue":"6","key":"2238_CR21","doi-asserted-by":"publisher","first-page":"e2165","DOI":"10.1002\/hsr2.2165","volume":"7","author":"SA Nejadghaderi","year":"2024","unstructured":"Nejadghaderi SA, Balibegloo M, Rezaei N. The Cochrane risk of bias assessment tool 2 (RoB 2) versus the original RoB: a perspective on the pros and cons. Health Sci Rep. 2024;7(6):e2165.","journal-title":"Health Sci Rep"},{"issue":"1002","key":"2238_CR22","first-page":"14651858","volume":"4","author":"J Chandler","year":"2019","unstructured":"Chandler J, Cumpston M, Li T, Page MJ, Welch V. Cochrane handbook for systematic reviews of interventions. Hoboken: Wiley. 2019;4(1002):14651858.","journal-title":"Hoboken: Wiley"},{"issue":"4","key":"2238_CR23","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jspi.2009.09.017","volume":"140","author":"D Jackson","year":"2010","unstructured":"Jackson D, Bowden J, Baker R. How does the DerSimonian and Laird procedure for random effects meta-analysis compare with its more efficient but harder to compute counterparts? J Stat Plann Inference. 2010;140(4):961\u201370.","journal-title":"J Stat Plann Inference"},{"issue":"10","key":"2238_CR24","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1002\/ptr.6716","volume":"34","author":"M Khorshidi","year":"2020","unstructured":"Khorshidi M, Zarezadeh M, Moradi Moghaddam O, Emami MR, Kord-Varkaneh H, Mousavi SM, et al. Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta\u2010analysis of randomized clinical trials. Phytother Res. 2020;34(10):2628\u201338.","journal-title":"Phytother Res"},{"issue":"3","key":"2238_CR25","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/jpc.16789","volume":"61","author":"S An","year":"2025","unstructured":"An S, Kong J, Ghorbani A, Dehghani A, Alizadeh S. Effect of Pro-, Pre\u2010and Synbiotic Supplementation on the Growth of Infants and Children: An Umbrella Systematic Review and Meta\u2010Analysis. J Paediatr Child Health. 2025;61(3):354\u201368.","journal-title":"J Paediatr Child Health"},{"issue":"2","key":"2238_CR26","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s12072-012-9387-y","volume":"7","author":"V Gianturco","year":"2013","unstructured":"Gianturco V, Troisi G, Bellomo A, Bernardini S, D\u2019Ottavio E, Formosa V, et al. Impact of combined therapy with alpha-lipoic and ursodeoxycolic acid on nonalcoholic fatty liver disease: double-blind, randomized clinical trial of efficacy and safety. Hep Intl. 2013;7(2):570\u20136.","journal-title":"Hep Intl"},{"issue":"3","key":"2238_CR27","first-page":"1","volume":"20","author":"S Hosseinpour-Arjmand","year":"2018","unstructured":"Hosseinpour-Arjmand S, Hamedi-Shahraki S, Ebrahimi-Mameghani M, Amirkhizi F. The effect of alpha-lipoic acid on liver function and metabolic markers in obese patients with non-alcoholic fatty liver disease: a double-blind randomized controlled trial. Iran Red Crescent Med J. 2018;20(3):1\u201311.","journal-title":"Iran Red Crescent Med J"},{"issue":"8","key":"2238_CR28","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.1039\/C9FO00449A","volume":"10","author":"A Rahmanabadi","year":"2019","unstructured":"Rahmanabadi A, Mahboob S, Amirkhizi F, Hosseinpour-Arjmand S, Ebrahimi-Mameghani M. Oral \u03b1-lipoic acid supplementation in patients with non-alcoholic fatty liver disease: effects on adipokines and liver histology features. Food Funct. 2019;10(8):4941\u201352.","journal-title":"Food Funct"},{"issue":"1","key":"2238_CR29","first-page":"101704","volume":"17","author":"ADC Contreras","year":"2025","unstructured":"Contreras ADC, Francisco MDR, Basurto JLV, Gonzalez-Gomez KD, Amieva-Balmori M, Dietlen FR, Remes-Troche JM. Effect of alpha-lipoic acid and Silybum marianum supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17(1):101704.","journal-title":"World J Hepatol"},{"issue":"10","key":"2238_CR30","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1111\/j.1478-3231.2012.02857.x","volume":"32","author":"TS Jung","year":"2012","unstructured":"Jung TS, Kim SK, Shin HJ, Jeon BT, Hahm JR, Roh GS. \u03b1-lipoic acid prevents non\u2010alcoholic fatty liver disease in OLETF rats. Liver Int. 2012;32(10):1565\u201373.","journal-title":"Liver Int"},{"key":"2238_CR31","first-page":"455","volume":"28","author":"T Farhadi","year":"2024","unstructured":"Farhadi T, Jalili A, Sharafabad FH. Effect of Alpha-Lipoic Acid on Non-Alcoholic Fatty Liver Disease: A Systematic Review of In Vitro and In Vivo Studies. Iran Biomed J. 2024;28:455.","journal-title":"Iran Biomed J"},{"issue":"6","key":"2238_CR32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.31083\/j.fbl2906209","volume":"29","author":"L Longhitano","year":"2024","unstructured":"Longhitano L, Tibullo D, Zuppelli T, Ronsisvalle S, La Spina E, Nicolosi A, et al. (+) alpha-lipoic acid regulates lipid metabolism gene expression and Lipidic profile in a cellular model of fatty acid overload. Front Bioscience-Landmark. 2024;29(6):209.","journal-title":"Front Bioscience-Landmark"},{"key":"2238_CR33","first-page":"100073","volume":"4","author":"MO Awoleye","year":"2024","unstructured":"Awoleye MO, Adedeji TG. Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism. Pharmacol Research-Natural Prod. 2024;4:100073.","journal-title":"Pharmacol Research-Natural Prod"},{"issue":"10","key":"2238_CR34","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/aps.2014.64","volume":"35","author":"Y Yang","year":"2014","unstructured":"Yang Y, Li W, Liu Y, Li Y, Gao L, Zhao J-j. Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice. Acta Pharmacol Sin. 2014;35(10):1285\u201392.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2238_CR35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12967-024-04880-x","volume":"22","author":"L Longhitano","year":"2024","unstructured":"Longhitano L, Distefano A, Musso N, Bonacci P, Orlando L, Giallongo S, et al. (+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease. J Translational Med. 2024;22(1):82.","journal-title":"J Translational Med"},{"issue":"4","key":"2238_CR36","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1177\/039463201302600405","volume":"26","author":"F Mignini","year":"2013","unstructured":"Mignini F, Nasuti C, Fedeli D, Mattioli L, Cosenza M, Artico M, Gabbianelli R. Protective effect of alpha-lipoic acid on cypermethrin-induced oxidative stress in Wistar rats. Int J ImmunoPathol Pharmacol. 2013;26(4):871\u201381.","journal-title":"Int J ImmunoPathol Pharmacol"},{"issue":"1","key":"2238_CR37","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s10753-015-0256-4","volume":"39","author":"F Petronilho","year":"2016","unstructured":"Petronilho F, Florentino D, Danielski LG, Vieira LC, Martins MM, Vieira A, et al. Alpha-lipoic acid attenuates oxidative damage in organs after sepsis. Inflammation. 2016;39(1):357\u201365.","journal-title":"Inflammation"},{"issue":"48","key":"2238_CR38","doi-asserted-by":"publisher","first-page":"6909","DOI":"10.3748\/wjg.v28.i48.6909","volume":"28","author":"VN Bukke","year":"2022","unstructured":"Bukke VN, Moola A, Serviddio G, Vendemiale G, Bellanti F. Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease. World J Gastroenterol. 2022;28(48):6909.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"2238_CR39","doi-asserted-by":"publisher","first-page":"4088","DOI":"10.1111\/jcmm.14296","volume":"23","author":"D Xia","year":"2019","unstructured":"Xia D, Zhai X, Wang H, Chen Z, Fu C, Zhu M. Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury. J Cell Mol Med. 2019;23(6):4088\u201396.","journal-title":"J Cell Mol Med"},{"issue":"12","key":"2238_CR40","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1210\/jc.2006-0587","volume":"91","author":"KM Utzschneider","year":"2006","unstructured":"Utzschneider KM, Kahn SE. The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metabolism. 2006;91(12):4753\u201361.","journal-title":"J Clin Endocrinol Metabolism"},{"issue":"3","key":"2238_CR41","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s001250050047","volume":"43","author":"K Yaworsky","year":"2000","unstructured":"Yaworsky K, Somwar R, Ramlal T, Tritschler H, Klip A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by \u03b1-lipoic acid in 3T3-L1 adipocytes. Diabetologia. 2000;43(3):294\u2013303.","journal-title":"Diabetologia"},{"issue":"8","key":"2238_CR42","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0024-3205(97)00562-6","volume":"61","author":"EJ Henriksen","year":"1997","unstructured":"Henriksen EJ, Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ. Stimulation by \u03b1-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sci. 1997;61(8):805\u201312.","journal-title":"Life Sci"},{"issue":"3","key":"2238_CR43","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.bbrc.2005.05.035","volume":"332","author":"WJ Lee","year":"2005","unstructured":"Lee WJ, Song K-H, Koh EH, Won JC, Kim HS, Park H-S, et al. \u03b1-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun. 2005;332(3):885\u201391.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"2238_CR44","first-page":"2144","volume":"18","author":"MA Ebada","year":"2019","unstructured":"Ebada MA, Fayed N, Fayed L, Alkanj S, Abdelkarim A, Farwati H, et al. Efficacy of alpha-lipoic acid in the management of diabetes mellitus: a systematic review and meta-analysis. Iran J Pharm research: IJPR. 2019;18(4):2144.","journal-title":"Iran J Pharm research: IJPR"},{"issue":"4","key":"2238_CR45","doi-asserted-by":"publisher","first-page":"e088363","DOI":"10.1136\/bmjopen-2024-088363","volume":"15","author":"Y Luo","year":"2025","unstructured":"Luo Y, Zhang J, Guo H. Alpha-lipoic acid on intermediate disease markers in overweight or obese adults: a systematic review and meta-analysis. BMJ open. 2025;15(4):e088363.","journal-title":"BMJ open"},{"issue":"2","key":"2238_CR46","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s40200-019-00423-0","volume":"18","author":"R Tabrizi","year":"2019","unstructured":"Tabrizi R, Borhani-Haghighi A, Mirhosseini N, Lankarani KB, Naghibzadeh-Tahami A, Akbari M, et al. The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metabolic Disorders. 2019;18(2):585\u201395.","journal-title":"J Diabetes Metabolic Disorders"},{"issue":"1","key":"2238_CR47","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5468\/ogs.23206","volume":"67","author":"A Abu-Zaid","year":"2024","unstructured":"Abu-Zaid A, Baradwan S, Bukhari IA, Alyousef A, Abuzaid M, Saleh SA, et al. The effect of alpha-lipoic acid supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in individuals with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials. Obstet Gynecol Sci. 2024;67(1):17\u201329.","journal-title":"Obstet Gynecol Sci"},{"issue":"10","key":"2238_CR48","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","volume":"54","author":"JA Sterne","year":"2001","unstructured":"Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001;54(10):1046\u201355.","journal-title":"J Clin Epidemiol"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-026-02238-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02238-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02238-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:08:32Z","timestamp":1778490512000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12902-026-02238-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2238"],"URL":"https:\/\/doi.org\/10.1186\/s12902-026-02238-6","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"22 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"133"}}