{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:15:10Z","timestamp":1778033710887,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"DOI":"10.1186\/s12902-026-02239-5","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:05:37Z","timestamp":1774602337000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endocrine and neurological complications in total versus completion thyroidectomy: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"2239_CR1","doi-asserted-by":"crossref","unstructured":"Ahmed A, Kheraj M, Bergquist A, R. Exploring the determinants of thyroid disorders in high-altitude western Himalaya: a geospatial and epidemiological study. J Health Popul Nutr. 2025;44(1):236","DOI":"10.1186\/s41043-025-00844-z"},{"key":"2239_CR2","doi-asserted-by":"crossref","unstructured":"Wouters H, Slagter SN, Muller Kobold AC, van der Klauw MM, Wolffenbuttel BHR. Epidemiology of thyroid disorders in the lifelines cohort study (the Netherlands). PLoS One. 2020;15(11):e0242795","DOI":"10.1371\/journal.pone.0242795"},{"issue":"3","key":"2239_CR3","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1097\/MS9.0000000000003055","volume":"87","author":"H Azarbakhsh","year":"2025","unstructured":"Azarbakhsh H, Nikbakht H-A, Hamedi A, Hashemi SN, Ebrahimi P, Jahani M-A. The mortality rate and years of life lost due to cancer in a city of north of islamic Republic of Iran during the years 2013-2021. joinpoint regression analysis. Ann Med Surg. 2025;87(3):1243\u201350","journal-title":"Ann Med Surg"},{"key":"2239_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/bmb\/ldr030","volume":"99","author":"MP Vanderpump","year":"2011","unstructured":"Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99:39\u201351","journal-title":"Br Med Bull"},{"issue":"10","key":"2239_CR5","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.mpaic.2023.07.009","volume":"24","author":"MB Shahid","year":"2023","unstructured":"Shahid MB, Cetera B. Thyroid disease and thyroid surgery. Anaesth Intensive Care Med. 2023;24(10):594\u2013607","journal-title":"Anaesth Intensive Care Med"},{"key":"2239_CR6","doi-asserted-by":"crossref","unstructured":"Thyroidectomy SC. Complications in small animal Surgery2016. 185\u201392","DOI":"10.1002\/9781119421344.ch26"},{"issue":"1","key":"2239_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/ohn.712","volume":"171","author":"NV Nagururu","year":"2024","unstructured":"Nagururu NV, Seo S, Ding AS, Grogan R, Wolfe SA, Harbison RA, et al. Long-term quality of life after thyroidectomy: transoral endoscopic thyroidectomy vestibular approach versus transcervical approach. Otolaryngology-Head Neck Surg. 2024;171(1):45\u201353","journal-title":"Otolaryngology-Head Neck Surg"},{"key":"2239_CR8","doi-asserted-by":"crossref","unstructured":"Raffaelli M, Tempera SE, Sessa L, Lombardi CP, De Crea C, Bellantone R. Total thyroidectomy versus thyroid lobectomy in the treatment of papillary carcinoma. Gland Surg. 2020;9(Suppl 1):S18\u2013s27","DOI":"10.21037\/gs.2019.11.09"},{"key":"2239_CR9","doi-asserted-by":"crossref","unstructured":"Merchavy S, Forest V-I, Marom T, Hier MP, Mlynarek AM, McHugh T, et al. Incidence of postoperative hypocalcemia following total thyroidectomy versus completion thyroidectomy. Otolaryngology-Head Neck Surg. 2014;151(S1):P58\u2013P","DOI":"10.1177\/0194599814541627a92"},{"issue":"1","key":"2239_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/hed.27551","volume":"46","author":"PP Issa","year":"2024","unstructured":"Issa PP, Hossam E, Cheng JH, Magazine BM, Hussein M, Luo X, et al. Completion thyroidectomy: a safe option for high-volume surgeons. Head Neck. 2024;46(1):57\u201363","journal-title":"Head Neck"},{"issue":"4","key":"2239_CR11","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/wjs.12546","volume":"49","author":"A Sada","year":"2025","unstructured":"Sada A, Ramonell KM, McCoy KL, Habermann EB, Carty SE, Yip L. Does completion thyroid surgery pose a higher risk of complications? World J Surg. 2025;49(4):1034\u201339","journal-title":"World J Surg"},{"key":"2239_CR12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ijporl.2019.07.006","volume":"125","author":"W Jiang","year":"2019","unstructured":"Jiang W, Lee E, Newfield RS. The utility of intact parathyroid hormone level in managing hypocalcemia after thyroidectomy in children. Int J Pediatr Otorhinolaryngol. 2019;125:153\u201358","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"2239_CR13","doi-asserted-by":"publisher","first-page":"145749692211072","DOI":"10.1177\/14574969221107282","volume":"111","author":"I Lon\u010dar","year":"2022","unstructured":"Lon\u010dar I, van Kinschot CMJ, van Dijk SPJ, Franssen GJH, Visser EE, Peeters RP, et al. Persistent post-thyroidectomy hypoparathyroidism: a multicenter retrospective cohort study. Scand J Surg. 2022;111(2):14574969221107282","journal-title":"Scand J Surg"},{"key":"2239_CR14","doi-asserted-by":"crossref","unstructured":"Minni A, Rosati D, Cavaliere C, Ralli M, Sementilli G, Gallo A, et al. Total versus completion thyroidectomy: a multidimensional evaluation of long-term vocal alterations. Ear Nose Throat J. 2021;100(5_suppl):562s\u201368","DOI":"10.1177\/0145561319886156"},{"issue":"1","key":"2239_CR15","first-page":"29","volume":"58","author":"MA Ayman Mismar","year":"2024","unstructured":"Ayman Mismar MA, Obeidat F, Baeth Moh\u2019d Al-Rawashdeh, Albsoul N. Complications after Thyroidectomy; a Comparison among seven different surgical procedures and the impact of central compartment lymph nodes sampling: a cohort study. Jordan Med J. 2024;58(1):29\u201336","journal-title":"Jordan Med J"},{"issue":"1","key":"2239_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.anl.2018.03.009","volume":"46","author":"YM Park","year":"2019","unstructured":"Park YM, Kim JR, Oh KH, Cho JG, Baek SK, Kwon SY, et al. Comparison of functional outcomes after total thyroidectomy and completion thyroidectomy: hypoparathyroidism and postoperative complications. Auris Nasus Larynx. 2019;46(1):101\u201305","journal-title":"Auris Nasus Larynx"},{"issue":"4","key":"2239_CR17","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1007\/s12070-023-04031-6","volume":"75","author":"N Sonkhya","year":"2023","unstructured":"Sonkhya N, Agarwal S, Choudhary MP, Gupta N. Serial estimation of serum calcium and Ionic calcium level for early detection of hypocalcemia after Total\/Completion thyroidectomy. Indian J Otolaryngol Head Neck Surg. 2023;75(4):3493\u201396","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2239_CR18","doi-asserted-by":"crossref","unstructured":"Toraih EA, Hussein MH, Jishu JA, Landau MB, Abdelmaksoud A, Bashumeel YY, et al. Initial versus staged thyroidectomy for differentiated thyroid cancer: a Retrospective multi-dimensional cohort analysis of effectiveness and safety. Cancers (Basel). 2024;16(12)","DOI":"10.3390\/cancers16122250"},{"issue":"2","key":"2239_CR19","first-page":"119","volume":"12","author":"B Uhliarova","year":"2016","unstructured":"Uhliarova B, Hajtman A. Total thyroidectomy: safe and adequate treatment for papillary microcarcinoma of the thyroid gland. B-Ent. 2016;12(2):119\u201324","journal-title":"B-Ent"},{"issue":"6","key":"2239_CR20","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1159\/000487083","volume":"41","author":"MA Gulcelik","year":"2018","unstructured":"Gulcelik MA, Dogan L, Akgul GG, G\u00fcven EH, Ers\u00f6z Gulcelik N. Completion thyroidectomy: safer than thought. Oncol Res Treat. 2018;41(6):386\u201390","journal-title":"Oncol Res Treat"},{"issue":"1","key":"2239_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00423-024-03258-3","volume":"409","author":"P Lind","year":"2024","unstructured":"Lind P, Nordenstr\u00f6m E, Johansson L, Wallin G, Daskalakis K. Impact of fine-needle aspiration cytology in thyroidectomy extent and associated surgical morbidity in thyroid cancer. Langenbecks Arch Surg. 2024;409(1):68","journal-title":"Langenbecks Arch Surg"},{"issue":"4","key":"2239_CR22","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1245\/s10434-024-16707-6","volume":"32","author":"F Ansart","year":"2025","unstructured":"Ansart F, de Ponthaud C, Buffet C, Menegaux F, Gaujoux S, Chereau N. One- or two-step total thyroidectomy for cancer indications: a 20-year Retrospective study from a referral center. Ann Surg Oncol. 2025;32(4):2329\u201334","journal-title":"Ann Surg Oncol"},{"key":"2239_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jclinepi.2021.02.003","volume":"134","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. Updating guidance for reporting systematic reviews: development of the PRISMA, 2020 statement. J Clin Epidemiol. 2021;134:103\u201312","journal-title":"J Clin Epidemiol"},{"issue":"12","key":"2239_CR24","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s00595-020-02065-9","volume":"50","author":"B Abboud","year":"2020","unstructured":"Abboud B, El-Kheir A. Redo thyroid surgery without drains. Surg Today. 2020;50(12):1619\u201325","journal-title":"Surg Today"},{"issue":"10","key":"2239_CR25","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.3390\/cancers14102472","volume":"14","author":"GL Canu","year":"2022","unstructured":"Canu GL, Medas F, Cappellacci F, Giordano ABF, Gurrado A, Gambardella C, et al. Risk of complications in patients undergoing completion thyroidectomy after Hemithyroidectomy for thyroid nodule with indeterminate cytology: an Italian multicentre retrospective study. Cancers (Basel). 2022;14(10):2472","journal-title":"Cancers (Basel)"},{"issue":"1","key":"2239_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.surg.2015.07.038","volume":"159","author":"M Raffaelli","year":"2016","unstructured":"Raffaelli M, De Crea C, D\u2019Amato G, Moscato U, Bellantone C, Carrozza C, et al. Post-thyroidectomy hypocalcemia is related to parathyroid dysfunction even in patients with normal parathyroid hormone concentrations early after surgery. Surgery. 2016;159(1):78\u201384","journal-title":"Surgery"},{"issue":"11","key":"2239_CR27","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/jamaoto.2021.2475","volume":"147","author":"I Loncar","year":"2021","unstructured":"Loncar I, Noltes ME, Dickhoff C, Engelsman AF, Schepers A, Vriens MR, et al. Persistent postthyroidectomy hypoparathyroidism in the Netherlands. JAMA Otolaryngol Head Neck Surg. 2021;147(11):959\u201365","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"3","key":"2239_CR28","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/XEB.0000000000000054","volume":"13","author":"MS Munn Z","year":"2015","unstructured":"Munn Z MS, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and incidence data. Int J Evid Based Healthc. 2015;13(3):147\u201353","journal-title":"Int J Evid Based Healthc"},{"issue":"1","key":"2239_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2049-3258-72-39","volume":"72","author":"VN Nyaga","year":"2014","unstructured":"Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Archives Public Health. 2014;72(1):1\u201310","journal-title":"Archives Public Health"},{"issue":"7414","key":"2239_CR30","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u201360","journal-title":"BMJ"},{"issue":"11","key":"2239_CR31","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539\u201358","journal-title":"Stat Med"},{"issue":"8","key":"2239_CR32","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.jclinepi.2014.03.003","volume":"67","author":"JP Hunter","year":"2014","unstructured":"Hunter JP, Saratzis A, Sutton AJ, Boucher RH, Sayers RD, Bown MJ. In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias. J Clin Epidemiol. 2014;67(8):897\u2013903","journal-title":"J Clin Epidemiol"},{"issue":"4","key":"2239_CR33","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/jso.26044","volume":"122","author":"PH Dedhia","year":"2020","unstructured":"Dedhia PH, Stoeckl EM, McDow AD, Pitt SC, Schneider DF, Sippel RS, et al. Outcomes after completion thyroidectomy versus total thyroidectomy for differentiated thyroid cancer: a single-center experience. J Surg Oncol. 2020;122(4):660\u201364","journal-title":"J Surg Oncol"},{"issue":"3","key":"2239_CR34","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1530\/EJE-21-0353","volume":"185","author":"D Giordano","year":"2021","unstructured":"Giordano D, Botti C, Piana S, Zini M, Frasoldati A, Lusetti F, et al. Postoperative hypoparathyroidism after completion thyroidectomy for well-differentiated thyroid cancer. Eur J Endocrinol. 2021;185(3):413\u201319","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2239_CR35","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1159\/000440690","volume":"38","author":"YJ Li","year":"2015","unstructured":"Li YJ, Wang YZ, Yi ZB, Chen LL, Zhou XD. Comparison of completion thyroidectomy and primary total surgery for differentiated thyroid cancer: a meta-analysis. Oncol Res Treat. 2015;38(10):528\u201331","journal-title":"Oncol Res Treat"},{"key":"2239_CR36","doi-asserted-by":"crossref","unstructured":"Merchavy S, Marom T, Forest H VI, Mlynarek M, A M, T, et al. Comparison of the incidence of postoperative hypocalcemia following total thyroidectomy vs completion thyroidectomy. Otolaryngol Head Neck Surg. 2015;152(1):53\u201356","DOI":"10.1177\/0194599814556250"},{"issue":"3","key":"2239_CR37","doi-asserted-by":"publisher","first-page":"118","DOI":"10.4274\/tao.2023.2023-5-19","volume":"61","author":"FY Emre","year":"2023","unstructured":"Emre FY, Do\u011fan E, Keskino\u011flu P, Durak MG, Sar\u0131o\u011flu S, \u0130kiz A. Evaluation of thyroidectomy results performed at a tertiary academic center. Turk Arch Otorhinolaryngol. 2023;61(3):118\u201323","journal-title":"Turk Arch Otorhinolaryngol"},{"issue":"1","key":"2239_CR38","doi-asserted-by":"publisher","first-page":"32730","DOI":"10.1038\/s41598-025-18227-z","volume":"15","author":"O Aslan","year":"2025","unstructured":"Aslan O, \u015eahin M, Topcu R, Per\u00e7em AK, Sezikli \u0130, Y\u00fcksek MA, et al. Surgical outcomes and complications of completion thyroidectomy: a retrospective study. Sci Rep. 2025;15(1):32730","journal-title":"Sci Rep"},{"issue":"2","key":"2239_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.17691\/stm2020.12.2.13","volume":"12","author":"AA Melikyan","year":"2020","unstructured":"Melikyan AA, Menkov AV. Postoperative hypoparathyroidism: prognosis, prevention, and treatment (review). Sovrem Tekhnologii Med. 2020;12(2):101\u201308","journal-title":"Sovrem Tekhnologii Med"},{"key":"2239_CR40","doi-asserted-by":"crossref","unstructured":"Mirghani H, Altedlawi Albalawi IA. The ongoing debate regarding completion thyroidectomy versus primary thyroid surgery for low and intermediate differentiated thyroid carcinoma: a meta-analysis. Cureus. 2020, 2nd;12(12):e12033","DOI":"10.7759\/cureus.12033"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-026-02239-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02239-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02239-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:53:23Z","timestamp":1778032403000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12902-026-02239-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2239"],"URL":"https:\/\/doi.org\/10.1186\/s12902-026-02239-5","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"15 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}