{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:48Z","timestamp":1791082008074,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571005"],"award-info":[{"award-number":["82571005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Science and technology development Foundation, Nanjing Department of Health","award":["YKK24104"],"award-info":[{"award-number":["YKK24104"]}]},{"name":"the Jiangsu Provincial Health Service Research","award":["M2024050"],"award-info":[{"award-number":["M2024050"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"DOI":"10.1186\/s12902-026-02344-5","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:35:38Z","timestamp":1780990538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower prolactin levels are associated with histological severity of metabolic dysfunction-associated steatotic liver disease"],"prefix":"10.1186","volume":"26","author":[{"given":"Huayang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"2344_CR1","doi-asserted-by":"publisher","unstructured":"Easl-Easd-easo clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)[J]. J Hepatol. 2024;81(3):492\u2013542. https:\/\/doi.org\/10.1016\/j.jhep.2024.04.031.","DOI":"10.1016\/j.jhep.2024.04.031"},{"issue":"2","key":"2344_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1001\/jama.2025.19615","volume":"335","author":"H Tilg","year":"2026","unstructured":"Tilg H, Petta S, Stefan N, et al. Metabolic Dysfunction-Associated Steatotic Liver Disease in Adults: A Review[J]. JAMA. 2026;335(2):163\u201374. https:\/\/doi.org\/10.1001\/jama.2025.19615.","journal-title":"JAMA"},{"key":"2344_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejim.2023.11.005","volume":"122","author":"V Lekakis","year":"2024","unstructured":"Lekakis V, Papatheodoridis GV. Natural history of metabolic dysfunction-associated steatotic liver disease[J]. Eur J Intern Med. 2024;122:3\u201310. https:\/\/doi.org\/10.1016\/j.ejim.2023.11.005.","journal-title":"Eur J Intern Med"},{"key":"2344_CR4","doi-asserted-by":"publisher","first-page":"100386","DOI":"10.1016\/j.ahjo.2024.100386","volume":"41","author":"AJ Sanyal","year":"2024","unstructured":"Sanyal AJ, Husain M, Diab C, et al. Cardiovascular disease in patients with metabolic dysfunction-associated steatohepatitis compared with metabolic dysfunction-associated steatotic liver disease and other liver diseases: A systematic review[J]. Am Heart J Plus. 2024;41:100386. https:\/\/doi.org\/10.1016\/j.ahjo.2024.100386.","journal-title":"Am Heart J Plus"},{"key":"2344_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-026-00918-y","author":"M Rahbari","year":"2026","unstructured":"Rahbari M, Gris-Oliver A, Ramadori P, et al. The versatile interplay between steatotic liver disease and liver cancer[J]. Nat Rev Cancer. 2026. https:\/\/doi.org\/10.1038\/s41568-026-00918-y.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2344_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s10620-024-08722-0","volume":"70","author":"KC Miller","year":"2025","unstructured":"Miller KC, Geyer B, Alexopoulos AS, et al. Disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease Prevalence, Diagnosis, Treatment, and Outcomes: A Narrative Review[J]. Dig Dis Sci. 2025;70(1):154\u201367. https:\/\/doi.org\/10.1007\/s10620-024-08722-0.","journal-title":"Dig Dis Sci"},{"issue":"1","key":"2344_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","volume":"23","author":"Y Li","year":"2024","unstructured":"Li Y, Yang P, Ye J, et al. Updated mechanisms of MASLD pathogenesis[J]. Lipids Health Dis. 2024;23(1):117. https:\/\/doi.org\/10.1186\/s12944-024-02108-x.","journal-title":"Lipids Health Dis"},{"issue":"6","key":"2344_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41574-019-0194-6","volume":"15","author":"V Bernard","year":"2019","unstructured":"Bernard V, Young J, Binart N. Prolactin - a pleiotropic factor in health and disease[J]. Nat Rev Endocrinol. 2019;15(6):356\u201365. https:\/\/doi.org\/10.1038\/s41574-019-0194-6.","journal-title":"Nat Rev Endocrinol"},{"key":"2344_CR9","doi-asserted-by":"publisher","unstructured":"Macotela Y, Triebel J, Clapp C. Time for a new perspective on prolactin in metabolism[J]. Trends Endocrinol Metab. 2020;31(4): 276\u2009\u2013\u200986. https:\/\/doi.org\/10.1016\/j.tem.2020.01.004.","DOI":"10.1016\/j.tem.2020.01.004"},{"issue":"6","key":"2344_CR10","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s11154-024-09886-w","volume":"25","author":"G Ken-Dror","year":"2024","unstructured":"Ken-Dror G, Fluck D, Lean MEJ, et al. The relationship between low prolactin and type 2 diabetes[J]. Rev Endocr Metab Disord. 2024;25(6):1087\u201395. https:\/\/doi.org\/10.1007\/s11154-024-09886-w.","journal-title":"Rev Endocr Metab Disord"},{"issue":"2","key":"2344_CR11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s12020-019-02170-x","volume":"67","author":"AJ Ponce","year":"2020","unstructured":"Ponce AJ, Galv\u00e1n-Salas T, Lerma-Alvarado RM, et al. Low prolactin levels are associated with visceral adipocyte hypertrophy and insulin resistance in humans[J]. Endocrine. 2020;67(2):331\u201343. https:\/\/doi.org\/10.1007\/s12020-019-02170-x.","journal-title":"Endocrine"},{"issue":"10","key":"2344_CR12","doi-asserted-by":"publisher","first-page":"e062252","DOI":"10.1136\/bmjopen-2022-062252","volume":"12","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Liu H. Cross-sectional association between prolactin levels and non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus: a retrospective analysis of patients from a single hospital in China[J]. BMJ Open. 2022;12(10):e062252. https:\/\/doi.org\/10.1136\/bmjopen-2022-062252.","journal-title":"BMJ Open"},{"issue":"1","key":"2344_CR13","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1186\/s12876-022-02619-w","volume":"22","author":"P Xu","year":"2022","unstructured":"Xu P, Zhu Y, Ji X, et al. Lower serum PRL is associated with the development of non-alcoholic fatty liver disease: a retrospective cohort study[J]. BMC Gastroenterol. 2022;22(1):523. https:\/\/doi.org\/10.1186\/s12876-022-02619-w.","journal-title":"BMC Gastroenterol"},{"issue":"6","key":"2344_CR14","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.jhep.2018.01.035","volume":"68","author":"P Zhang","year":"2018","unstructured":"Zhang P, Ge Z, Wang H, et al. Prolactin improves hepatic steatosis via CD36 pathway[J]. J Hepatol. 2018;68(6):1247\u201355. https:\/\/doi.org\/10.1016\/j.jhep.2018.01.035.","journal-title":"J Hepatol"},{"issue":"4","key":"2344_CR15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.jhep.2025.09.019","volume":"84","author":"C Lackner","year":"2026","unstructured":"Lackner C, Gouw ASH, Avancini Ferreira Alves V, et al. Consensus position statements for the standardized application of histological grading and staging systems in MASH clinical trials[J]. J Hepatol. 2026;84(4):693\u2013701. https:\/\/doi.org\/10.1016\/j.jhep.2025.09.019.","journal-title":"J Hepatol"},{"key":"2344_CR16","doi-asserted-by":"publisher","unstructured":"Ahamed Y, Ashraf SB, Dauty RT, et al. Sex and age specific hormonal patterns in healthy Chinese individuals: a cross-sectional study of reproductive hormones[J]. Sci Rep. 2026;16(1). https:\/\/doi.org\/10.1038\/s41598-025-34399-0.","DOI":"10.1038\/s41598-025-34399-0"},{"issue":"6","key":"2344_CR17","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s12325-017-0556-1","volume":"34","author":"S Ballestri","year":"2017","unstructured":"Ballestri S, Nascimbeni F, Baldelli E, et al. NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk[J]. Adv Ther. 2017;34(6):1291\u2013326. https:\/\/doi.org\/10.1007\/s12325-017-0556-1.","journal-title":"Adv Ther"},{"key":"2344_CR18","doi-asserted-by":"publisher","first-page":"1762596","DOI":"10.3389\/fendo.2026.1762596","volume":"17","author":"Y Wang","year":"2026","unstructured":"Wang Y, Luo D, Fang G, et al. From the perspective of prolactin: a view on obesity[J]. Front Endocrinol (Lausanne). 2026;17:1762596. https:\/\/doi.org\/10.3389\/fendo.2026.1762596.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2344_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.5603\/ep.108313","volume":"77","author":"G Stupecki","year":"2026","unstructured":"Stupecki G, Krzos D, Nawacki \u0141, et al. Body mass index as a predictor of metabolic dysfunction\u2013associated steatotic liver disease - insights from the Polish Gallstone Surgery Registry[J]. Endokrynol Pol. 2026;77(1):51\u201361. https:\/\/doi.org\/10.5603\/ep.108313.","journal-title":"Endokrynol Pol"},{"issue":"7","key":"2344_CR20","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.2337\/dc12-1893","volume":"36","author":"T Wang","year":"2013","unstructured":"Wang T, Lu J, Xu Y, et al. Circulating prolactin associates with diabetes and impaired glucose regulation: a population-based study[J]. Diabetes Care. 2013;36(7):1974\u201380. https:\/\/doi.org\/10.2337\/dc12-1893.","journal-title":"Diabetes Care"},{"issue":"Supplement1","key":"2344_CR21","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.2337\/dc26-S002","volume":"49","author":"Diagnosis and Classification of Diabetes","year":"2026","unstructured":"Diagnosis and Classification of Diabetes. Standards of Care in Diabetes-2026[J]. Diabetes Care. 2026;49(Supplement1):S27\u201349. https:\/\/doi.org\/10.2337\/dc26-S002.","journal-title":"Diabetes Care"},{"issue":"7","key":"2344_CR22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/bf00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia. 1985;28(7):412\u20139. https:\/\/doi.org\/10.1007\/bf00280883.","journal-title":"Diabetologia"},{"issue":"4","key":"2344_CR23","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","volume":"80","author":"ME Freeman","year":"2000","unstructured":"Freeman ME, Kanyicska B, Lerant A, et al. Prolactin: structure, function, and regulation of secretion[J]. Physiol Rev. 2000;80(4):1523\u2013631. https:\/\/doi.org\/10.1152\/physrev.2000.80.4.1523.","journal-title":"Physiol Rev"},{"key":"2344_CR24","doi-asserted-by":"publisher","unstructured":"Macotela Y, Triebel J, Clapp C. Time for a new perspective on prolactin in metabolism[J]. Trends Endocrinol Metab. 2020;31(4): 276\u2009\u2013\u200986. https:\/\/doi.org\/10.1016\/j.tem.2020.01.004.","DOI":"10.1016\/j.tem.2020.01.004"},{"key":"2344_CR25","doi-asserted-by":"publisher","first-page":"1015520","DOI":"10.3389\/fendo.2022.1015520","volume":"13","author":"R Pirchio","year":"2022","unstructured":"Pirchio R, Graziadio C, Colao A, et al. Metabolic effects of prolactin[J]. Front Endocrinol (Lausanne). 2022;13:1015520. https:\/\/doi.org\/10.3389\/fendo.2022.1015520.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"2344_CR26","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.metabol.2016.01.012","volume":"65","author":"Y Fazel","year":"2016","unstructured":"Fazel Y, Koenig AB, Sayiner M, et al. Epidemiology and natural history of non-alcoholic fatty liver disease[J]. Metabolism. 2016;65(8):1017\u201325. https:\/\/doi.org\/10.1016\/j.metabol.2016.01.012.","journal-title":"Metabolism"},{"issue":"28","key":"2344_CR27","doi-asserted-by":"publisher","first-page":"9330","DOI":"10.3748\/wjg.v20.i28.9330","volume":"20","author":"S Mili\u0107","year":"2014","unstructured":"Mili\u0107 S, Luli\u0107 D. \u0160timac D Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations[J]. World J Gastroenterol. 2014;20(28):9330\u20137. https:\/\/doi.org\/10.3748\/wjg.v20.i28.9330.","journal-title":"World J Gastroenterol"},{"issue":"5","key":"2344_CR28","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/s00125-003-1088-6","volume":"46","author":"AI Arroba","year":"2003","unstructured":"Arroba AI, Frago LM, Pa\u00f1eda C, et al. The number of lactotrophs is reduced in the anterior pituitary of streptozotocin-induced diabetic rats[J]. Diabetologia. 2003;46(5):634\u20138. https:\/\/doi.org\/10.1007\/s00125-003-1088-6.","journal-title":"Diabetologia"},{"key":"2344_CR29","doi-asserted-by":"publisher","unstructured":"Ferdous SE, Ferrell JM, Pathophysiological. Relationship between type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease: novel therapeutic approaches[J]. Int J Mol Sci. 2024;25(16). https:\/\/doi.org\/10.3390\/ijms25168731.","DOI":"10.3390\/ijms25168731"},{"issue":"6","key":"2344_CR30","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1023\/a:1025429318932","volume":"135","author":"TY Zenkova","year":"2003","unstructured":"Zenkova TY, Kulikov AV, Bogorad RL, et al. Expression of prolactin receptors in human liver during cholestasis of different etiology and secondary liver cancer[J]. Bull Exp Biol Med. 2003;135(6):566\u20139. https:\/\/doi.org\/10.1023\/a:1025429318932.","journal-title":"Bull Exp Biol Med"},{"issue":"2\u20133","key":"2344_CR31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0303-7207(85)90163-7","volume":"40","author":"KW Tsim","year":"1985","unstructured":"Tsim KW, Pak RC, Cheng CH. Prolactin receptor in rat liver: sex difference in estrogenic stimulation and imprinting of the responsiveness to estrogen by neonatal androgen in male rats[J]. Mol Cell Endocrinol. 1985;40(2\u20133):99\u2013105. https:\/\/doi.org\/10.1016\/0303-7207(85)90163-7.","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"2344_CR32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0303-7207(77)90120-4","volume":"9","author":"PA Kelly","year":"1977","unstructured":"Kelly PA, LeBlanc G, Ferland L, et al. Androgen inhibition of basal and estrogen-stimulated prolactin binding in rat liver[J]. Mol Cell Endocrinol. 1977;9(2):195-204. https:\/\/doi.org\/10.1016\/0303-7207(77)90120-4","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2344_CR33","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1677\/jme.0.0270093","volume":"27","author":"L Bj\u00f6rnstr\u00f6m","year":"2001","unstructured":"Bj\u00f6rnstr\u00f6m L, Kilic E, Norman M, et al. Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells[J]. J Mol Endocrinol. 2001;27(1):93\u2013106. https:\/\/doi.org\/10.1677\/jme.0.0270093.","journal-title":"J Mol Endocrinol"},{"key":"2344_CR34","doi-asserted-by":"publisher","first-page":"815995","DOI":"10.3389\/fendo.2022.815995","volume":"13","author":"C Zhu","year":"2022","unstructured":"Zhu C, Ma H, Huang D, et al. J-Shaped Relationship Between Serum Prolactin and Metabolic-Associated Fatty Liver Disease in Female Patients With Type 2 Diabetes[J]. Front Endocrinol (Lausanne). 2022;13:815995. https:\/\/doi.org\/10.3389\/fendo.2022.815995.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2344_CR35","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.bbrc.2018.03.048","volume":"498","author":"S Shao","year":"2018","unstructured":"Shao S, Yao Z, Lu J, et al. Ablation of prolactin receptor increases hepatic triglyceride accumulation[J]. Biochem Biophys Res Commun. 2018;498(3):693\u20139. https:\/\/doi.org\/10.1016\/j.bbrc.2018.03.048.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"2344_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","volume":"15","author":"S Schuster","year":"2018","unstructured":"Schuster S, Cabrera D, Arrese M, et al. Triggering and resolution of inflammation in NASH[J]. Nat Rev Gastroenterol Hepatol. 2018;15(6):349\u201364. https:\/\/doi.org\/10.1038\/s41575-018-0009-6.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"10","key":"2344_CR37","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.1007\/s11695-020-04771-2","volume":"30","author":"X Wang","year":"2020","unstructured":"Wang X, Ma B, Li G, et al. Glucose-Lipid Metabolism in Obesity with Elevated Prolactin Levels and Alteration of Prolactin Levels After Laparoscopic Sleeve Gastrectomy[J]. Obes Surg. 2020;30(10):4004\u201313. https:\/\/doi.org\/10.1007\/s11695-020-04771-2.","journal-title":"Obes Surg"},{"issue":"4","key":"2344_CR38","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/cen.12183","volume":"79","author":"V Chirico","year":"2013","unstructured":"Chirico V, Cannav\u00f2 S, Lacquaniti A, et al. Prolactin in obese children: a bridge between inflammation and metabolic-endocrine dysfunction[J]. Clin Endocrinol (Oxf). 2013;79(4):537\u201344. https:\/\/doi.org\/10.1111\/cen.12183.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2344_CR39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/hep.28776","volume":"65","author":"V Ajmera","year":"2017","unstructured":"Ajmera V, Perito ER, Bass NM, et al. Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease[J]. Hepatology. 2017;65(1):65\u201377. https:\/\/doi.org\/10.1002\/hep.28776.","journal-title":"Hepatology"},{"issue":"1","key":"2344_CR40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11095-024-03791-2","volume":"42","author":"IK Minichmayr","year":"2025","unstructured":"Minichmayr IK, Plan EL, WEBER B, et al. A Model-Based Evaluation of Noninvasive Biomarkers to Reflect Histological Nonalcoholic Fatty Liver Disease Scores[J]. Pharm Res. 2025;42(1):123\u201335. https:\/\/doi.org\/10.1007\/s11095-024-03791-2.","journal-title":"Pharm Res"},{"issue":"12","key":"2344_CR41","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1001\/jama.2020.2298","volume":"323","author":"AC Sheka","year":"2020","unstructured":"Sheka AC, Adeyi O, Thompson J, et al. Nonalcoholic Steatohepatitis: A Review[J]. JAMA. 2020;323(12):1175\u201383. https:\/\/doi.org\/10.1001\/jama.2020.2298.","journal-title":"JAMA"},{"issue":"1","key":"2344_CR42","doi-asserted-by":"publisher","first-page":"71-8","DOI":"10.1007\/s00592-013-0493-7","volume":"51","author":"R Wagner","year":"2014","unstructured":"WagnerR, Heni M, Linder K, et al. Age-dependent association of serum prolactin with glycaemia and insulin sensitivity in humans[J]. Acta Diabetol. 2014;51(1):71\u20138. https:\/\/doi.org\/10.1007\/s00592-013-0493-7.","journal-title":"Acta Diabetol"},{"key":"2344_CR43","doi-asserted-by":"publisher","DOI":"10.1080\/19382014.2017.1330234","author":"TC Bhagroo","year":"2017","unstructured":"BreljeTC, Bhagroo NV, Stout LE, et al. Prolactin and oleic acid synergistically stimulate \u03b2-cell proliferation and growth in rat islets[J]. Islets. 2017;9(4):e1330234. https:\/\/doi.org\/10.1080\/19382014.2017.1330234.","journal-title":"Islets"},{"key":"2344_CR44","doi-asserted-by":"publisher","unstructured":"Nardelli TR, Vanzela EC,Benedicto KC, et al. Prolactin protects against cytokine-induced beta-cell death by NF\u03baB and JNK inhibition[J]. J Mol Endocrinol. 2018;61(1):25\u201336. https:\/\/doi.org\/10.1530\/JME-16-0257.","DOI":"10.1530\/JME-16-0257"},{"key":"2344_CR45","doi-asserted-by":"publisher","unstructured":"Singh S, Allen AM, Wang Z et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies[J]. Clin Gastroenterol Hepatol. 2015;13(4):643\u201354.e1-9; quiz e39-40. https:\/\/doi.org\/10.1016\/j.cgh.2014.04.014.","DOI":"10.1016\/j.cgh.2014.04.014"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-026-02344-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02344-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02344-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:28:46Z","timestamp":1786660126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12902-026-02344-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2344"],"URL":"https:\/\/doi.org\/10.1186\/s12902-026-02344-5","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study complied with the Declaration of Helsinki and all other relevant ethical guidelines. The Ethics Committee of Nanjing Drum Tower Hospital approved the study\u2019s protocol (2017-030-08, 2021-388-01), which we registered on ClinicalTrials.gov (number NCT03296605, date 2017-12-09). Written informed consent was given by each participant.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"234"}}