{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:37:48Z","timestamp":1792787868455,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The research reported in this project was generously supported by the National Natural Science Foundation of China under grant agreement number","award":["82160866"],"award-info":[{"award-number":["82160866"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"DOI":"10.1186\/s12902-026-02354-3","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:36:56Z","timestamp":1783046216000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MCD biomarkers Egfr, Hmox1, Lgmn identified in NAFLD"],"prefix":"10.1186","volume":"26","author":[{"given":"Kai-yang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"4","key":"2354_CR1","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3350\/cmh.2022.0239","volume":"28","author":"MH Le","year":"2022","unstructured":"Le MH, Yeo YH, Zou B, Barnet S, Henry L, Cheung R, et al. Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach. Clin Mol Hepatol. 2022;28(4):841\u201350.","journal-title":"Clin Mol Hepatol"},{"issue":"4","key":"2354_CR2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.2174\/0109298665301698240404061300","volume":"31","author":"M Sotoudeheian","year":"2024","unstructured":"Sotoudeheian M. Galectin-3 and Severity of Liver Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease. Protein Pept Lett. 2024;31(4):290\u2013304.","journal-title":"Protein Pept Lett"},{"issue":"1","key":"2354_CR3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","volume":"76","author":"F Bessone","year":"2019","unstructured":"Bessone F, Razori MV, Roma MG. Molecular pathways of nonalcoholic fatty liver disease development and progression. Cell Mol Life Sci. 2019;76(1):99\u2013128.","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"2354_CR4","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","volume":"150","author":"MV Machado","year":"2016","unstructured":"Machado MV, Diehl AM. Pathogenesis of Nonalcoholic Steatohepatitis. Gastroenterology. 2016;150(8):1769\u201377.","journal-title":"Gastroenterology"},{"key":"2354_CR5","doi-asserted-by":"publisher","first-page":"e18761429259143","DOI":"10.2174\/0118761429259143230927110556","volume":"17","author":"Y Xu","year":"2024","unstructured":"Xu Y, An Z, Wang S, Ni Y, Zhou M, Feng Q, et al. Dual Role of Pregnane X Receptor in Nonalcoholic Fatty Liver Disease. Curr Mol Pharmacol. 2024;17:e18761429259143.","journal-title":"Curr Mol Pharmacol"},{"issue":"28","key":"2354_CR6","first-page":"9338","volume":"20","author":"W Nseir","year":"2014","unstructured":"Nseir W, Hellou E, Assy N. Role of diet and lifestyle changes in nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(28):9338\u201344.","journal-title":"World J Gastroenterol"},{"issue":"4","key":"2354_CR7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.jhep.2017.05.016","volume":"67","author":"M Romero-G\u00f3mez","year":"2017","unstructured":"Romero-G\u00f3mez M, Zelber-Sagi S, Trenell M. Treatment of NAFLD with diet, physical activity and exercise. J Hepatol. 2017;67(4):829\u201346.","journal-title":"J Hepatol"},{"issue":"9","key":"2354_CR8","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/procel\/pwae003","volume":"15","author":"C Mao","year":"2024","unstructured":"Mao C, Wang M, Zhuang L, Gan B. Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond. Protein Cell. 2024;15(9):642\u201360.","journal-title":"Protein Cell"},{"key":"2354_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12876-022-02137-9","volume":"22","author":"X Dai","year":"2022","unstructured":"Dai X, Zhang R, Wang B. Contribution of classification based on ferroptosisrelated genes to the heterogeneity of Mafld. BMC Gastroenterol. 2022;22:55.","journal-title":"BMC Gastroenterol"},{"key":"2354_CR10","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","volume":"7","author":"J Wu","year":"2021","unstructured":"Wu J, Wang Y, Jiang R, Xue R, Yin X, Wu M, et al. Ferroptosis in liver disease: new insights into disease mechanisms. Cell Death Discov. 2021;7:276.","journal-title":"Cell Death Discov"},{"key":"2354_CR11","doi-asserted-by":"publisher","first-page":"1033129","DOI":"10.3389\/fnut.2022.1033129","volume":"9","author":"Q Wu","year":"2022","unstructured":"Wu Q, Chen Z, Ding Y, Tang Y, Cheng Y. Protective effect of traditional Chinese medicine on non-alcoholic fatty liver disease and liver cancer by targeting ferroptosis. Front Nutr. 2022;9:1033129.","journal-title":"Front Nutr"},{"issue":"11","key":"2354_CR12","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.3390\/biomedicines9111660","volume":"9","author":"H Zhang","year":"2021","unstructured":"Zhang H, Zhang E, Hu H. Role of ferroptosis in non-alcoholic fatty liver disease and its implications for therapeutic strategies. Biomedicines. 2021;9(11):1660.","journal-title":"Biomedicines"},{"issue":"14","key":"2354_CR13","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.3748\/wjg.v30.i14.1968","volume":"30","author":"HJ Sun","year":"2024","unstructured":"Sun HJ, Jiao B, Wang Y, Zhang YH, Chen G, Wang ZX, et al. Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions. World J Gastroenterol. 2024;30(14):1968\u201381.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"2354_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2174\/0113892029313473240919105819","volume":"26","author":"X He","year":"2025","unstructured":"He X, Ma J, Yan X, Yang X, Wang P, Zhang L, et al. CDT1 is a potential therapeutic target for the progression of NAFLD to HCC and the exacerbation of cancer. Curr Genomics. 2025;26(3):225\u201343.","journal-title":"Curr Genomics"},{"issue":"2","key":"2354_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/0113892029280454240214072212","volume":"25","author":"A Mahmoudi","year":"2024","unstructured":"Mahmoudi A, Hajihasani MM, Majeed M, Jamialahmadi T, Sahebkar A. Effect of Calebin-A on critical genes related to NAFLD: a protein-protein interaction network and molecular docking study. Curr Genomics. 2024;25(2):120\u201339.","journal-title":"Curr Genomics"},{"issue":"7","key":"2354_CR16","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2354_CR17","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.1038\/psp.2013.56","volume":"2","author":"K Ito","year":"2013","unstructured":"Ito K, Murphy D. Application of ggplot2 to Pharmacometric Graphics. CPT Pharmacometrics Syst Pharmacol. 2013;2(10):e79.","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"issue":"18","key":"2354_CR18","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","volume":"32","author":"Z Gu","year":"2016","unstructured":"Gu Z, Eils R, Schlesner M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016;32(18):2847\u20139.","journal-title":"Bioinformatics"},{"key":"2354_CR19","doi-asserted-by":"publisher","first-page":"1076523","DOI":"10.3389\/fmicb.2023.1076523","volume":"14","author":"T Zhou","year":"2023","unstructured":"Zhou T, Liu S, Jiang A. Comparison of gut microbiota between immigrant and native populations of the Silver-eared Mesia (Leiothrix argentauris) living in mining area. Front Microbiol. 2023;14:1076523.","journal-title":"Front Microbiol"},{"issue":"3","key":"2354_CR20","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov (Camb). 2021;2(3):100141.","journal-title":"Innov (Camb)"},{"key":"2354_CR21","doi-asserted-by":"publisher","first-page":"1181510","DOI":"10.3389\/fphys.2023.1181510","volume":"14","author":"Y Jin","year":"2023","unstructured":"Jin Y, Ren W, Liu J, Tang X, Shi X, Pan D, et al. Identification and validation of potential hypoxia-related genes associated with coronary artery disease. Front Physiol. 2023;14:1181510.","journal-title":"Front Physiol"},{"issue":"17","key":"2354_CR22","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","volume":"31","author":"W Walter","year":"2015","unstructured":"Walter W, S\u00e1nchez-Cabo F, Ricote M. GOplot: an R package for visually combining expression data with functional analysis. Bioinformatics. 2015;31(17):2912\u20134.","journal-title":"Bioinformatics"},{"issue":"1","key":"2354_CR23","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/1744-9987.14188","volume":"29","author":"B Lv","year":"2025","unstructured":"Lv B, Liu W, Lu Y, Wang Z, Shi A. Machine learning-based prediction of vancomycin concentration after abdominal administration in patients with peritoneal dialysis-related peritonitis. Ther Apher Dial. 2025;29(1):106\u201313.","journal-title":"Ther Apher Dial"},{"issue":"1","key":"2354_CR24","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s13054-023-04683-4","volume":"27","author":"C Guan","year":"2023","unstructured":"Guan C, Ma F, Chang S, Zhang J. Interpretable machine learning models for predicting venous thromboembolism in the intensive care unit: an analysis based on data from 207 centers. Crit Care. 2023;27(1):406.","journal-title":"Crit Care"},{"key":"2354_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, et al. pROC: an open-source package for R and S\u2009+\u2009to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"2354_CR26","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.recesp.2011.01.019","volume":"64","author":"E N\u00fa\u00f1ez","year":"2011","unstructured":"N\u00fa\u00f1ez E, Steyerberg EW, N\u00fa\u00f1ez J. Estrategias para la elaboraci\u00f3n de modelos estad\u00edsticos de regresi\u00f3n [Regression modeling strategies]. Rev Esp Cardiol. 2011;64(6):501\u20137.","journal-title":"Rev Esp Cardiol"},{"key":"2354_CR27","doi-asserted-by":"publisher","first-page":"5878460","DOI":"10.1155\/2022\/5878460","volume":"2022","author":"L Wang","year":"2022","unstructured":"Wang L, Wang Y, Liu J, Zhao W. Identification of Important Genes of Keratoconus and Construction of the Diagnostic Model. Genet Res (Camb). 2022;2022:5878460.","journal-title":"Genet Res (Camb)"},{"key":"2354_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14:7.","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"2354_CR29","doi-asserted-by":"publisher","first-page":"e18091","DOI":"10.1111\/jcmm.18091","volume":"28","author":"C Liu","year":"2024","unstructured":"Liu C, Fang Z, Yang K, Ji Y, Yu X, Guo Z, et al. Identification and validation of cuproptosis-related molecular clusters in non-alcoholic fatty liver disease. J Cell Mol Med. 2024;28(3):e18091.","journal-title":"J Cell Mol Med"},{"issue":"11","key":"2354_CR30","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498\u2013504.","journal-title":"Genome Res"},{"issue":"5","key":"2354_CR31","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1002\/ptr.8166","volume":"38","author":"R Damare","year":"2024","unstructured":"Damare R, Engle K, Kumar G. Targeting epidermal growth factor receptor and its downstream signaling pathways by natural products: A mechanistic insight. Phytother Res. 2024;38(5):2406\u201347.","journal-title":"Phytother Res"},{"issue":"12","key":"2354_CR32","doi-asserted-by":"publisher","first-page":"119359","DOI":"10.1016\/j.bbamcr.2022.119359","volume":"1869","author":"LA Orofiamma","year":"2022","unstructured":"Orofiamma LA, Vural D, Antonescu CN. Control of cell metabolism by the epidermal growth factor receptor. Biochim Biophys Acta Mol Cell Res. 2022;1869(12):119359.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"11","key":"2354_CR33","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1002\/1873-3468.14636","volume":"597","author":"F Shao","year":"2023","unstructured":"Shao F, Deng H, Zhang W, Ren Z, Kang Z, Ding Z, et al. Loss of EGFR contributes to high-fat diet-induced nonalcoholic fatty liver disease. FEBS Lett. 2023;597(11):1503\u201316.","journal-title":"FEBS Lett"},{"issue":"1","key":"2354_CR34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bbadis.2017.10.016","volume":"1864","author":"D Liang","year":"2018","unstructured":"Liang D, Chen H, Zhao L, Zhang W, Hu J, Liu Z, et al. Inhibition of EGFR attenuates fibrosis and stellate cell activation in diet-induced model of nonalcoholic fatty liver disease. Biochim Biophys Acta Mol Basis Dis. 2018;1864(1):133\u201342.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"7","key":"2354_CR35","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1039\/D2FO02701A","volume":"14","author":"YW Huang","year":"2023","unstructured":"Huang YW, Wang LT, Zhang M, Nie Y, Yang JB, Meng WL, et al. Caffeine can alleviate non-alcoholic fatty liver disease by augmenting LDLR expression via targeting EGFR. Food Funct. 2023;14(7):3269\u201378.","journal-title":"Food Funct"},{"issue":"6","key":"2354_CR36","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3390\/antiox12061217","volume":"12","author":"H Wang","year":"2023","unstructured":"Wang H, Cheng Q, Bao L, Li M, Chang K, Yi X. Cytoprotective Role of Heme Oxygenase-1 in Cancer Chemoresistance: Focus on Antioxidant, Antiapoptotic, and Pro-Autophagy Properties. Antioxid (Basel). 2023;12(6):1217.","journal-title":"Antioxid (Basel)"},{"issue":"4","key":"2354_CR37","first-page":"291","volume":"27","author":"XW Yuan","year":"2019","unstructured":"Yuan XW, Li DD, Liu LD, Zhang Y, Zhao W, Cui LY, et al. Application of heme oxygenase 1 in the diagnosis of non-alcoholic fatty liver disease. Zhonghua Gan Zang Bing Za Zhi. 2019;27(4):291\u20137.","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"2354_CR38","doi-asserted-by":"publisher","first-page":"103314","DOI":"10.1016\/j.redox.2024.103314","volume":"76","author":"H Yanagisawa","year":"2024","unstructured":"Yanagisawa H, Maeda H, Noguchi I, Tanaka M, Wada N, Nagasaki T, et al. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation. Redox Biol. 2024;76:103314.","journal-title":"Redox Biol"},{"issue":"24","key":"2354_CR39","doi-asserted-by":"publisher","first-page":"15983","DOI":"10.3390\/ijms232415983","volume":"23","author":"R Solberg","year":"2022","unstructured":"Solberg R, Lunde NN, Forbord KM, Okla M, Kassem M, Jafari A. The Mammalian Cysteine Protease Legumain in Health and Disease. Int J Mol Sci. 2022;23(24):15983.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2354_CR40","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1186\/s12864-023-09842-z","volume":"24","author":"L Yan","year":"2023","unstructured":"Yan L, Han X, Zhang M, Fu Y, Yang F, Li Q, et al. Integrative analysis of TBI data reveals Lgmn as a key player in immune cell-mediated ferroptosis. BMC Genomics. 2023;24(1):747.","journal-title":"BMC Genomics"},{"key":"2354_CR41","doi-asserted-by":"publisher","first-page":"112283","DOI":"10.1016\/j.mce.2024.112283","volume":"592","author":"W Zhang","year":"2024","unstructured":"Zhang W, Wang S, Liu Z, Qian P, Li Y, Wu J. Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity. Mol Cell Endocrinol. 2024;592:112283.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2354_CR42","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12944-023-01911-2","volume":"22","author":"H Jiang","year":"2023","unstructured":"Jiang H, Hu Y, Zhang Z, Chen X, Gao J. Identification of metabolic biomarkers associated with nonalcoholic fatty liver disease. Lipids Health Dis. 2023;22(1):150.","journal-title":"Lipids Health Dis"},{"issue":"24","key":"2354_CR43","doi-asserted-by":"publisher","first-page":"9682","DOI":"10.3390\/ijms21249682","volume":"21","author":"L Shojaie","year":"2020","unstructured":"Shojaie L, Iorga A, Dara L. Cell Death in Liver Diseases: A Review. Int J Mol Sci. 2020;21(24):9682.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2354_CR44","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jhep.2023.10.025","volume":"80","author":"Z Lei","year":"2024","unstructured":"Lei Z, Yu J, Wu Y, Shen J, Lin S, Xue W, et al. CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis. J Hepatol. 2024;80(2):194\u2013208.","journal-title":"J Hepatol"},{"issue":"1","key":"2354_CR45","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/nu14010076","volume":"14","author":"J Li","year":"2021","unstructured":"Li J, Xie S, Teng W. Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. Nutrients. 2021;14(1):76.","journal-title":"Nutrients"},{"issue":"7","key":"2354_CR46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.2174\/0115680266264206231020111820","volume":"24","author":"S Mishra","year":"2024","unstructured":"Mishra S, Sahu A, Kaur A, Kaur M, Kumar J, Wal P. Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore. Curr Top Med Chem. 2024;24(7):581\u2013613.","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"2354_CR47","doi-asserted-by":"publisher","first-page":"12199","DOI":"10.1038\/s41598-018-30652-x","volume":"8","author":"EA Prokhorova","year":"2018","unstructured":"Prokhorova EA, Kopeina GS, Lavrik IN, Zhivotovsky B. Apoptosis regulation by subcellular relocation of caspases. Sci Rep. 2018;8(1):12199.","journal-title":"Sci Rep"},{"key":"2354_CR48","doi-asserted-by":"publisher","first-page":"631256","DOI":"10.3389\/fphar.2021.631256","volume":"12","author":"B Liu","year":"2021","unstructured":"Liu B, He R, Zhang L, Hao B, Jiang W, Wang W, et al. Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury. Front Pharmacol. 2021;12:631256.","journal-title":"Front Pharmacol"},{"issue":"2","key":"2354_CR49","doi-asserted-by":"publisher","first-page":"74","DOI":"10.5830\/CVJA-2022-023","volume":"34","author":"R Kelly-Laubscher","year":"2023","unstructured":"Kelly-Laubscher R, Somers S, Lacerda L, Lecour S. Role of nuclear factor kappa-B in TNF-induced cytoprotection. Cardiovasc J Afr. 2023;34(2):74\u201380.","journal-title":"Cardiovasc J Afr"},{"issue":"6","key":"2354_CR50","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2174\/1566524020666201026162343","volume":"21","author":"L Franceschetti","year":"2021","unstructured":"Franceschetti L, Bonomini F, Rodella LF, Rezzani R. Critical Role of NF\u03baB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator. Curr Mol Med. 2021;21(6):495\u2013505.","journal-title":"Curr Mol Med"},{"key":"2354_CR51","doi-asserted-by":"publisher","first-page":"1195699","DOI":"10.3389\/fimmu.2023.1195699","volume":"14","author":"B Alabdulaali","year":"2023","unstructured":"Alabdulaali B, Al-Rashed F, Al-Onaizi M, Kandari A, Razafiarison J, Tonui D, et al. Macrophages and the development and progression of non-alcoholic fatty liver disease. Front Immunol. 2023;14:1195699.","journal-title":"Front Immunol"},{"key":"2354_CR52","doi-asserted-by":"publisher","first-page":"1379967","DOI":"10.3389\/fimmu.2024.1379967","volume":"15","author":"S Yeudall","year":"2024","unstructured":"Yeudall S, Upchurch CM, Leitinger N. The clinical relevance of heme detoxification by the macrophage heme oxygenase system. Front Immunol. 2024;15:1379967.","journal-title":"Front Immunol"},{"issue":"8","key":"2354_CR53","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1111\/1759-7714.13504","volume":"11","author":"C Zhao","year":"2020","unstructured":"Zhao C, Su C, Li X, Zhou C. Association of CD8 T cell apoptosis and EGFR mutation in non-small lung cancer patients. Thorac Cancer. 2020;11(8):2130\u20136.","journal-title":"Thorac Cancer"},{"issue":"7","key":"2354_CR54","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00535-020-01679-7","volume":"55","author":"T Seike","year":"2020","unstructured":"Seike T, Mizukoshi E, Yamada K, Okada H, Kitahara M, Yamashita T, et al. Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients. J Gastroenterol. 2020;55(7):701\u201311.","journal-title":"J Gastroenterol"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-026-02354-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02354-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-026-02354-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:54:05Z","timestamp":1790654045000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12902-026-02354-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2354"],"URL":"https:\/\/doi.org\/10.1186\/s12902-026-02354-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9350660\/v1","asserted-by":"object"}]},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"8 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki and approved by the Ethics Committee of the Ethics Committee of the Guizhou University of Traditional Chinese Medicin. All patients provided written informed consent at the time of clinical sample collection for experiments, ensuring that the research process complied with ethical norms and that patients\u2019 rights and wishes were fully respected.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not adapted.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"294"}}