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The triglyceride-glucose A Body Shape Index (TyG-ABSI) composite index and inflammatory score are potential predictors of type 2 diabetes mellitus (T2DM). However, their independent and joint associations with incident T2DM in middle-aged and older Chinese adults remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS, 2011\u20132020), including 6,216 participants without diabetes at baseline. The TyG-ABSI index and inflammatory score (constructed from high-sensitivity C-reactive protein and white blood cell counts) were calculated. Multivariate Cox regression models, restricted cubic splines were used to evaluate their associations with incident T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher TyG-ABSI and higher inflammatory score were independently associated with an increased T2DM risk (fully adjusted hazard ratio [HR]: 1.42, 95% confidence interval [CI]: 1.17\u20131.72 and 1.21, 95% CI: 1.02\u20131.44, respectively). Participants with concurrent high TyG-ABSI and high inflammatory score had a 69% higher T2DM risk (HR: 1.69, 95% CI: 1.30\u20132.21) than the reference group. Restricted cubic spline analyses showed approximately linear dose-response relationships. The combined index demonstrated superior discriminative ability (Harrell\u2019s C-index) and significantly improved risk reclassification (NRI) and overall discrimination (IDI) compared with traditional risk factors alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TyG-ABSI composite index and inflammatory score were independently and jointly associated with incident T2DM in middle-aged and older Chinese adults. This combined application can improve T2DM risk stratification and facilitate early prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-026-02370-3","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:14:02Z","timestamp":1781860442000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint association of TyG-ABSI composite index and inflammatory score with diabetes in middle-aged and older Chinese adults: a prospective cohort study from CHARLS (2011\u20132020)"],"prefix":"10.1186","volume":"26","author":[{"given":"Qingqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"issue":"2","key":"2370_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S2213-8587(25)00299-2","volume":"14","author":"I Genitsaridi","year":"2026","unstructured":"Genitsaridi I, Salpea P, Salim A, Sajjadi SF, Tomic D, James S, et al. 11th edition of the IDF diabetes atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050. 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