{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:33:18Z","timestamp":1787239998882,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12903-015-0045-3","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T11:40:53Z","timestamp":1431517253000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Periodontitis associated with plasminogen deficiency: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Sarah H","family":"Neering","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Adyani-Fard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Klocke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"R\u00fcttermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Flemmig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beikler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"issue":"2","key":"45_CR1","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.ajpath.2011.05.003","volume":"179","author":"R Sulniute","year":"2011","unstructured":"Sulniute R, Lindh T, Wilczynska M, Li J, Ny T. Plasmin is essential in preventing periodontitis in mice. Am J Pathol. 2011;179(2):819\u201328. doi:10.1016\/j.ajpath.2011.05.003.","journal-title":"Am J Pathol"},{"issue":"4","key":"45_CR2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1902\/jop.2011.110261","volume":"83","author":"S Sivolella","year":"2012","unstructured":"Sivolella S, De Biagi M, Sartori MT, Berengo M, Bressan E. Destructive membranous periodontal disease (ligneous gingivitis): a literature review. J Periodontol. 2012;83(4):465\u201376. doi:10.1902\/jop.2011.110261.","journal-title":"J Periodontol"},{"key":"45_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0065-230X(08)60028-7","volume":"44","author":"K Dano","year":"1985","unstructured":"Dano K, Andreasen PA, Grondahl-Hansen J, Kristensen P, Nielsen LS, Skriver L. Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res. 1985;44:139\u2013266.","journal-title":"Adv Cancer Res"},{"issue":"6","key":"45_CR4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0049-3848(98)00122-4","volume":"91","author":"P Carmeliet","year":"1998","unstructured":"Carmeliet P, Collen D. Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system. Thromb Res. 1998;91(6):255\u201385.","journal-title":"Thromb Res"},{"issue":"5","key":"45_CR5","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00018-010-0566-5","volume":"68","author":"J Schaller","year":"2011","unstructured":"Schaller J, Gerber SS. The plasmin-antiplasmin system: structural and functional aspects. Cell Mol Life Sci. 2011;68(5):785\u2013801. doi:10.1007\/s00018-010-0566-5.","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"45_CR6","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1182\/blood.V93.10.3457.410k03_3457_3466","volume":"93","author":"V Schuster","year":"1999","unstructured":"Schuster V, Seidenspinner S, Zeitler P, Escher C, Pleyer U, Bernauer W, et al. Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. Blood. 1999;93(10):3457\u201366.","journal-title":"Blood"},{"issue":"4","key":"45_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0039-6257(03)00056-0","volume":"48","author":"V Schuster","year":"2003","unstructured":"Schuster V, Seregard S. Ligneous conjunctivitis. Surv Ophthalmol. 2003;48(4):369\u201388.","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"45_CR8","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1902\/jop.2007.060422","volume":"78","author":"I Kurtulus","year":"2007","unstructured":"Kurtulus I, Gokbuget A, Efeoglu A, Cintan S, Tefs K, Schuster V, et al. Hypoplasminogenemia with ligneous periodontitis: a failed local therapeutic approach. J Periodontol. 2007;78(6):1164\u201375. doi:10.1902\/jop.2007.060422.","journal-title":"J Periodontol"},{"issue":"12","key":"45_CR9","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1111\/j.1538-7836.2007.02776.x","volume":"5","author":"V Schuster","year":"2007","unstructured":"Schuster V, Hugle B, Tefs K. Plasminogen deficiency. J Thromb Haemost. 2007;5(12):2315\u201322. doi:10.1111\/j.1538-7836.2007.02776.x.","journal-title":"J Thromb Haemost"},{"issue":"9","key":"45_CR10","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1182\/blood-2006-04-017350","volume":"108","author":"K Tefs","year":"2006","unstructured":"Tefs K, Gueorguieva M, Klammt J, Allen CM, Aktas D, Anlar FY, et al. Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients. Blood. 2006;108(9):3021\u20136. doi:10.1182\/blood-2006-04-017350.","journal-title":"Blood"},{"issue":"3","key":"45_CR11","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1160\/TH10-04-0216","volume":"105","author":"J Klammt","year":"2011","unstructured":"Klammt J, Kobelt L, Aktas D, Durak I, Gokbuget A, Hughes Q, et al. Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity. Thromb Haemost. 2011;105(3):454\u201360. doi:10.1160\/TH10-04-0216.","journal-title":"Thromb Haemost"},{"issue":"6","key":"45_CR12","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/j.1365-2516.2008.01825.x","volume":"14","author":"R Mehta","year":"2008","unstructured":"Mehta R, Shapiro AD. Plasminogen deficiency. Haemophilia. 2008;14(6):1261\u20138. doi:10.1111\/j.1365-2516.2008.01825.x.","journal-title":"Haemophilia"},{"key":"45_CR13","first-page":"11","volume":"10","author":"J Lindhe","year":"1977","unstructured":"Lindhe J, Nyman S. The role of occlusion in periodontal disease and the biological rationale for splinting in treatment of periodontitis. Oral Sci Rev. 1977;10:11\u201343.","journal-title":"Oral Sci Rev"},{"issue":"8","key":"45_CR14","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1902\/jop.2006.050204","volume":"77","author":"T Beikler","year":"2006","unstructured":"Beikler T, Schnitzer S, Abdeen G, Ehmke B, Eisenacher M, Flemmig TF. Sampling strategy for intraoral detection of periodontal pathogens before and following periodontal therapy. J Periodontol. 2006;77(8):1323\u201332. doi:10.1902\/jop.2006.050204.","journal-title":"J Periodontol"},{"issue":"8","key":"45_CR15","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1177\/00220345950740080501","volume":"74","author":"M Quirynen","year":"1995","unstructured":"Quirynen M, Bollen CM, Vandekerckhove BN, Dekeyser C, Papaioannou W, Eyssen H. Full- vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J Dent Res. 1995;74(8):1459\u201367.","journal-title":"J Dent Res"},{"key":"45_CR16","volume-title":"Adjuvante Antibiotika in der Parodontitistherapie. Wissenschaftliche Stellungnahme DGZMK und DGP","author":"T Beikler","year":"2003","unstructured":"Beikler T, Karch H, Flemmig TF. Adjuvante Antibiotika in der Parodontitistherapie. Wissenschaftliche Stellungnahme DGZMK und DGP. 2003."},{"issue":"1","key":"45_CR17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1902\/jop.2004.75.1.169","volume":"75","author":"T Beikler","year":"2004","unstructured":"Beikler T, Prior K, Ehmke B, Flemmig TF. Specific antibiotics in the treatment of periodontitis\u2013a proposed strategy. J Periodontol. 2004;75(1):169\u201375. doi:10.1902\/jop.2004.75.1.169.","journal-title":"J Periodontol"},{"issue":"1","key":"45_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.tripleo.2008.08.007","volume":"107","author":"G Fine","year":"2009","unstructured":"Fine G, Bauer K, Al-Mohaya M, Woo SB. Successful treatment of ligneous gingivitis with warfarin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(1):77\u201380. doi:10.1016\/j.tripleo.2008.08.007.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"1","key":"45_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/DAD.0b013e3182169507","volume":"34","author":"O Gunhan","year":"2012","unstructured":"Gunhan O, Avci A, Dereci O, Akgun S, Celasun B. Extensive fibrin accumulation and accompanying epithelial changes in the pathogenesis of ligneous mucosal disease (ligneous periodontitis). Am J Dermatopathol. 2012;34(1):35\u201340. doi:10.1097\/DAD.0b013e3182169507.","journal-title":"Am J Dermatopathol"},{"issue":"9","key":"45_CR20","doi-asserted-by":"publisher","first-page":"923","DOI":"10.2174\/092986708783955455","volume":"15","author":"E Zorio","year":"2008","unstructured":"Zorio E, Gilabert-Estelles J, Espana F, Ramon LA, Cosin R, Estelles A. Fibrinolysis: the key to new pathogenetic mechanisms. Curr Med Chem. 2008;15(9):923\u20139.","journal-title":"Curr Med Chem"},{"issue":"4","key":"45_CR21","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1023\/A:1006256114463","volume":"22","author":"SK Rao","year":"1998","unstructured":"Rao SK, Biswas J, Rajagopal R, Sitalakshmi G, Padmanabhan P. Ligneous conjunctivitis: a clinicopathologic study of 3 cases. Int Ophthalmol. 1998;22(4):201\u20136.","journal-title":"Int Ophthalmol"},{"issue":"2","key":"45_CR22","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.anndiagpath.2008.02.005","volume":"13","author":"AC Chi","year":"2009","unstructured":"Chi AC, Prichard E, Richardson MS, Rasenberger KP, Weathers DR, Neville BW. Pseudomembranous disease (ligneous inflammation) of the female genital tract, peritoneum, gingiva, and paranasal sinuses associated with plasminogen deficiency. Ann Diagn Pathol. 2009;13(2):132\u20139. doi:10.1016\/j.anndiagpath.2008.02.005.","journal-title":"Ann Diagn Pathol"},{"issue":"6","key":"45_CR23","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1902\/jop.2010.100468","volume":"82","author":"M Aimetti","year":"2011","unstructured":"Aimetti M, Romano F, Guzzi N, Carnevale G. One-stage full-mouth disinfection as a therapeutic approach for generalized aggressive periodontitis. J Periodontol. 2011;82(6):845\u201353. doi:10.1902\/jop.2010.100468.","journal-title":"J Periodontol"},{"issue":"11","key":"45_CR24","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1902\/jop.2001.72.11.1624","volume":"72","author":"H Greenwell","year":"2001","unstructured":"Greenwell H. Position paper: Guidelines for periodontal therapy. J Periodontol. 2001;72(11):1624\u20138. doi:10.1902\/jop.2001.72.11.1624.","journal-title":"J Periodontol"},{"issue":"10","key":"45_CR25","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1902\/jop.2003.74.10.1508","volume":"74","author":"L Suresh","year":"2003","unstructured":"Suresh L, Aguirre A, Kumar V, Solomon LW, Sielski EA, Neiders ME. Recurrent recalcitrant gingival hyperplasia and plasminogen deficiency: a case report. J Periodontol. 2003;74(10):1508\u201313. doi:10.1902\/jop.2003.74.10.1508.","journal-title":"J Periodontol"},{"issue":"8","key":"45_CR26","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/sj.bdj.4811739","volume":"197","author":"T Baykul","year":"2004","unstructured":"Baykul T, Bozkurt Y. Destructive membranous periodontal disease (ligneous periodontitis): a case report and 3\u00a0years follow-up. Br Dent J. 2004;197(8):467\u20138. doi:10.1038\/sj.bdj.4811739.","journal-title":"Br Dent J"},{"issue":"3","key":"45_CR27","first-page":"179","volume":"73","author":"GB Silva","year":"2006","unstructured":"Silva GB, Bariani C, Mendonca EF, Batista AC. Clinical manifestations due to severe plasminogen deficiency: a case report. J Dent Child. 2006;73(3):179\u201382.","journal-title":"J Dent Child"},{"issue":"6","key":"45_CR28","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1016\/j.tripleo.2007.01.002","volume":"103","author":"H Toker","year":"2007","unstructured":"Toker H, Toker MI, Goze F, Turgut M, Yilmaz A. A ligneous periodontitis and conjunctival lesions in a patient with plasminogen deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(6):e35\u20138. doi:10.1016\/j.tripleo.2007.01.002.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"8","key":"45_CR29","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1902\/jop.1999.70.8.919","volume":"70","author":"O Gunhan","year":"1999","unstructured":"Gunhan O, Gunhan M, Berker E, Gurgan CA, Yildirim H. Destructive membranous periodontal disease (Ligneous periodontitis). J Periodontol. 1999;70(8):919\u201325. doi:10.1902\/jop.1999.70.8.919.","journal-title":"J Periodontol"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12903-015-0045-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-015-0045-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-015-0045-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-015-0045-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:15:26Z","timestamp":1599005726000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-015-0045-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["45"],"URL":"https:\/\/doi.org\/10.1186\/s12903-015-0045-3","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]},"assertion":[{"value":"23 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"59"}}