{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:58:50Z","timestamp":1740135530207,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["CRI 16041-1"],"award-info":[{"award-number":["CRI 16041-1"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["No. 2011-0030121"],"award-info":[{"award-number":["No. 2011-0030121"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12903-017-0379-0","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T12:26:19Z","timestamp":1495801579000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of chlormadinone acetate on odontogenic differentiation of human dental pulp cells: in vitro study"],"prefix":"10.1186","volume":"17","author":[{"given":"Se-Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin-Na","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Tae","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon-Sang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Nam","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won-Mann","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-San","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Chan","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"379_CR1","unstructured":"Seltzer S, Bender IB. The dental pulp: biologic considerations in dental procedures. Baltimore: Lippincott Williams & Wilkins; 1984."},{"key":"379_CR2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jdent.2010.05.016","volume":"38","author":"PR Cooper","year":"2010","unstructured":"Cooper PR, Takahashi Y, Graham LW, Simon S, Imazato S, Smith AJ. Inflammation\u2013regeneration interplay in the dentine\u2013pulp complex. J Dent. 2010;38:687\u201397.","journal-title":"J Dent"},{"key":"379_CR3","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","volume":"97","author":"S Gronthos","year":"2000","unstructured":"Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci. 2000;97:13625\u201330.","journal-title":"Proc Natl Acad Sci"},{"key":"379_CR4","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/154405910208100514","volume":"81","author":"JB Dale","year":"2002","unstructured":"Dale JB, Sarich SL, Bretz TM, Hatton JF, Zachow RJ. Hormonal regulation of androgen receptor messenger ribonucleic acid expression in human tooth pulp. J Dent Res. 2002;81:360\u20135.","journal-title":"J Dent Res"},{"key":"379_CR5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/03008209509016983","volume":"33","author":"WT Butler","year":"1995","unstructured":"Butler WT. Dentin matrix proteins and dentinogenesis. Connect Tissue Res. 1995;33:59\u201365.","journal-title":"Connect Tissue Res"},{"key":"379_CR6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0722.1998.tb02184.x","volume":"106","author":"C B\u00e8gue\u2010Kirn","year":"1998","unstructured":"B\u00e8gue\u2010Kirn C, Ruch JV, Ridall AL, Butler WT. Comparative analysis of mouse DSP and DPP expression in odontoblasts, preameloblasts, and experimentally induced odontoblast\u2010like cells. Eur J Oral Sci. 1998;106:254\u20139.","journal-title":"Eur J Oral Sci"},{"key":"379_CR7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/154405910208100607","volume":"81","author":"C Qin","year":"2002","unstructured":"Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, et al. The expression of dentin sialophosphoprotein gene in bone. J Dent Res. 2002;81:392\u20134.","journal-title":"J Dent Res"},{"key":"379_CR8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/cs0980217","volume":"98","author":"R Bland","year":"2000","unstructured":"Bland R. Steroid hormone receptor expression and action in bone. Clin Sci. 2000;98:217\u201340.","journal-title":"Clin Sci"},{"key":"379_CR9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1210\/edrv.23.3.0465","volume":"23","author":"BL Riggs","year":"2002","unstructured":"Riggs BL, Khosla S, Melton III LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002;23:279\u2013302.","journal-title":"Endocr Rev"},{"key":"379_CR10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2007.07.025","volume":"130","author":"T Nakamura","year":"2007","unstructured":"Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, et al. Estrogen prevents bone loss via estrogen receptor \u03b1 and induction of Fas ligand in osteoclasts. Cell. 2007;130:811\u201323.","journal-title":"Cell"},{"key":"379_CR11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/1043-2760(96)00024-0","volume":"7","author":"ES Orwoll","year":"1996","unstructured":"Orwoll ES. Androgens as anabolic agents for bone. Trends Endocrinol Metab. 1996;7:77\u201384.","journal-title":"Trends Endocrinol Metab"},{"key":"379_CR12","first-page":"37","volume":"81","author":"LG Raisz","year":"1996","unstructured":"Raisz LG, Wiita B, Artis A, Bowen A, Schwartz S, Trahiotis M, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab. 1996;81:37\u201343.","journal-title":"J Clin Endocrinol Metab"},{"key":"379_CR13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.contraception.2008.10.017","volume":"79","author":"R Druckmann","year":"2009","unstructured":"Druckmann R. Profile of the progesterone derivative chlormadinone acetate\u2014Pharmocodynamic properties and therapeutic applications. Contraception. 2009;79:272\u201381.","journal-title":"Contraception"},{"key":"379_CR14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/13625180500434889","volume":"10","author":"P Bouchard","year":"2005","unstructured":"Bouchard P. Chlormadinone acetate (CMA) in oral contraception\u2013a new opportunity. Eur J Contracept Reprod Health Care. 2005;10:7\u201311.","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"379_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2014.01.013","volume":"726","author":"JM Kim","year":"2014","unstructured":"Kim JM, Lee JE, Ryu SH, Suh PG. Chlormadinone acetate promotes osteoblast differentiation of human mesenchymal stem cells through the ERK signaling pathway. Eur J Pharmacol. 2014;726:1\u20138.","journal-title":"Eur J Pharmacol"},{"key":"379_CR16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 (Delta Delta C(T)) method. Methods. 2001;25:402\u20138.","journal-title":"Methods"},{"key":"379_CR17","first-page":"947","volume":"26","author":"K Ito","year":"2011","unstructured":"Ito K, Yamada Y, Nakamura S, Ueda M. Osteogenic potential of effective bone engineering using dental pulp stem cells, bone marrow stem cells, and periosteal cells for osseointegration of dental implants. Int J Oral Maxillofac Implants. 2011;26:947\u201354.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"379_CR18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.bone.2005.11.027","volume":"38","author":"R Garimella","year":"2006","unstructured":"Garimella R, Bi X, Anderson HC, Camacho NP. Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: an FTIR imaging study. Bone. 2006;38:811\u20137.","journal-title":"Bone"},{"key":"379_CR19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/tea.2007.0146","volume":"14","author":"W Zhang","year":"2008","unstructured":"Zhang W, Walboomers XF, van Osch GJ, van den Dolder J, Jansen JA. Hard tissue formation in a porous HA\/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. Tissue Eng Part A. 2008;14:285\u201394.","journal-title":"Tissue Eng Part A"},{"key":"379_CR20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.archoralbio.2010.12.008","volume":"56","author":"A Bakopoulou","year":"2011","unstructured":"Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P. Comparative analysis of in vitro osteo\/odontogenic differentiation potential of human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAP). Arch Oral Biol. 2011;56:709\u201321.","journal-title":"Arch Oral Biol"},{"key":"379_CR21","doi-asserted-by":"crossref","first-page":"19064","DOI":"10.1074\/jbc.M600714200","volume":"281","author":"K Narayanan","year":"2006","unstructured":"Narayanan K, Gajjeraman S, Ramachandran A, Hao J, George A. Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. J Biol Chem. 2006;281:19064\u201371.","journal-title":"J Biol Chem"},{"key":"379_CR22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/154411130401500103","volume":"15","author":"M Goldberg","year":"2004","unstructured":"Goldberg M, Smith AJ. Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering. Crit Rev Oral Biol Med. 2004;15:13\u201327.","journal-title":"Crit Rev Oral Biol Med"},{"key":"379_CR23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/03008200490464839","volume":"45","author":"D Magne","year":"2004","unstructured":"Magne D, Bluteau G, Lopez-Cazaux S, Weiss P, Pilet P, Ritchie HH. Development of an odontoblast in vitro model to study dentin mineralization. Connect Tissue Res. 2004;45:101\u20138.","journal-title":"Connect Tissue Res"},{"key":"379_CR24","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1152\/physiologyonline.1997.12.6.286","volume":"12","author":"JT Neary","year":"1997","unstructured":"Neary JT. MAPK cascades in cell growth and death. Physiology. 1997;12:286\u201393.","journal-title":"Physiology"},{"key":"379_CR25","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","volume":"298","author":"GL Johnson","year":"2002","unstructured":"Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298:1911\u20132.","journal-title":"Science"},{"key":"379_CR26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11033-011-0728-z","volume":"39","author":"X Zhao","year":"2012","unstructured":"Zhao X, He W, Song Z, Tong Z, Li S, Ni L. Mineral trioxide aggregate promotes odontoblastic differentiation via mitogen-activated protein kinase pathway in human dental pulp stem cells. Mol Biol Rep. 2012;39:215\u201320.","journal-title":"Mol Biol Rep"},{"key":"379_CR27","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.joen.2006.01.007","volume":"32","author":"L Ye","year":"2006","unstructured":"Ye L, Peng L, Tan H, Zhou X. HGF enhanced proliferation and differentiation of dental pulp cells. J Endod. 2006;32:736\u201341.","journal-title":"J Endod"},{"key":"379_CR28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1079-2104(99)70278-7","volume":"87","author":"SB Whitaker","year":"1999","unstructured":"Whitaker SB, Singh BB, Weller RN, Bath KR, Loushine RJ. Sex hormone receptor status of the dental pulp and lesions of pulpal origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:233\u20137.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"379_CR29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2329\/perio.31.166","volume":"31","author":"H Nanba","year":"1989","unstructured":"Nanba H, Nomura Y, Kinoshita M, Shimizu H, Ono K, Goto H, et al. Periodontal tissues and sex hormones. Effects of sex hormones on metabolism of fibroblasts derived from periodontal ligament. Nihon Shishubyo Gakkai kaishi. 1989;31:166\u201375.","journal-title":"Nihon Shishubyo Gakkai kaishi"},{"key":"379_CR30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9343(91)80156-G","volume":"90","author":"JC Gallagher","year":"1991","unstructured":"Gallagher JC, Kable WT, Goldgar D. Effect of progestin therapy on cortical and trabecular bone: comparison with estrogen. Am J Med. 1991;90:171\u20138.","journal-title":"Am J Med"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-017-0379-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T01:07:03Z","timestamp":1569373623000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-017-0379-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,26]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["379"],"URL":"https:\/\/doi.org\/10.1186\/s12903-017-0379-0","relation":{},"ISSN":["1472-6831"],"issn-type":[{"type":"electronic","value":"1472-6831"}],"subject":[],"published":{"date-parts":[[2017,5,26]]},"article-number":"89"}}