{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T21:17:09Z","timestamp":1775942229298,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009381","name":"International Medical University","doi-asserted-by":"publisher","award":["BDSI-01-14(08)2017, IMU"],"award-info":[{"award-number":["BDSI-01-14(08)2017, IMU"]}],"id":[{"id":"10.13039\/501100009381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12903-018-0637-9","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T15:21:21Z","timestamp":1540221681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The role of three interleukin 10 gene polymorphisms (\u2212\u20091082 A\u2009&gt;\u2009G, \u2212\u2009819 C\u2009&gt;\u2009T, \u2212\u2009592 A\u2009&gt;\u2009C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis"],"prefix":"10.1186","volume":"18","author":[{"given":"Hey Chiann","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaju Jacob","family":"Pulikkotil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-7149","authenticated-orcid":false,"given":"Cho","family":"Naing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"637_CR1","unstructured":"Newman MG, Takei H, Klokkevold PR, Carranza FA. Carranza's clinical periodontology. Elsevier Health Sciences. 11th Edn. 2011."},{"key":"637_CR2","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809\u201320.","journal-title":"Lancet"},{"key":"637_CR3","volume-title":"The WHO global oral health data bank","author":"WHO","year":"2007","unstructured":"WHO. The WHO global oral health data bank. Geneva: World Health Organization; 2007."},{"key":"637_CR4","volume-title":"National oral health survey in adults 2010.","author":"NOHSA","year":"2013","unstructured":"NOHSA. National oral health survey in adults 2010. Putrajaya: OHD MOH: Oral Health Division Minitsry of Health; 2013."},{"key":"637_CR5","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1177\/0022034512457373","volume":"91","author":"P Eke","year":"2012","unstructured":"Eke P, Dye B, Wei L, Thornton-Evans G, Genco R. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91:914\u201320.","journal-title":"J Dent Res"},{"key":"637_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontal. 1999;4:1\u20136.","journal-title":"Ann Periodontal"},{"key":"637_CR7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/154411130301400605","volume":"14","author":"D Kinane","year":"2003","unstructured":"Kinane D, Hart T. Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med. 2003;14:430\u201349.","journal-title":"Crit Rev Oral Biol Med"},{"key":"637_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","volume":"29","author":"W Ouyang","year":"2011","unstructured":"Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71\u2013109.","journal-title":"Annu Rev Immunol"},{"key":"637_CR9","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683\u2013765.","journal-title":"Annu Rev Immunol"},{"key":"637_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","volume":"32","author":"SS Iyer","year":"2012","unstructured":"Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32:23\u201363.","journal-title":"Crit Rev Immunol"},{"issue":"6","key":"637_CR11","doi-asserted-by":"publisher","first-page":"e0127496","DOI":"10.1371\/journal.pone.0127496","volume":"10","author":"X Gao","year":"2015","unstructured":"Gao X, Chen J, Tong Z, Yang G, Yao Y, Xu F, et al. Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis. PLoS One. 2015;10(6):e0127496.","journal-title":"PLoS One"},{"key":"637_CR12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/molehr\/7.2.201","volume":"7","author":"J Karhukorpi","year":"2001","unstructured":"Karhukorpi J, Laitinen T, Karttunen R, Tiilikainen AS. The functionally important IL-10 promoter polymorphism (\u22121082G\u2192A) is not a major genetic regulator in recurrent spontaneous abortions. Mol Hum Reprod. 2001;7:201\u20133.","journal-title":"Mol Hum Reprod"},{"key":"637_CR13","first-page":"66","volume":"13","author":"S Kilpinen","year":"2002","unstructured":"Kilpinen S, Huhtala H, Hurme M. The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. Eur Cytokine Netw. 2002;13:66\u201371.","journal-title":"Eur Cytokine Netw"},{"key":"637_CR14","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","volume":"8","author":"D Moher","year":"2010","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8:336\u201341.","journal-title":"Int J Surg"},{"key":"637_CR15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/978-1-84882-260-3","volume-title":"How to intelligently make sense of real data, descriptive statistics: guide to intelligent data analysis","author":"VMR Berthold","year":"2010","unstructured":"Berthold VMR, H\u00f6ppner BC, Klawonn F. How to intelligently make sense of real data, descriptive statistics: guide to intelligent data analysis. Germany: Springer; 2010. p. 315."},{"key":"637_CR16","unstructured":"Wells BS GA, O'Connell D, Peterson J, Welch V, Losos MP. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses 2014 ( http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp ). Accessed 12 July 2018."},{"key":"637_CR17","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2307\/2532296","volume":"48","author":"SW Guo","year":"1992","unstructured":"Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics. 1992;48:361\u201372.","journal-title":"Biometrics"},{"key":"637_CR18","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"J Higgins","year":"2002","unstructured":"Higgins J, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539\u201358.","journal-title":"Stat Med"},{"key":"637_CR19","unstructured":"Higgins J. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. www.cochrane-handbook.org . Accessed 12 July 2018. 2011."},{"key":"637_CR20","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629\u201334.","journal-title":"BMJ"},{"key":"637_CR21","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","volume":"54","author":"JA Sterne","year":"2001","unstructured":"Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001;54:1046\u201355.","journal-title":"J Clin Epidemiol"},{"key":"637_CR22","first-page":"1","volume-title":"User manual for trial sequential analysis (TSA)","author":"K Thorlund","year":"2011","unstructured":"Thorlund K, Wetterslev J, Brok J, Imberger G, Gluud G. User manual for trial sequential analysis (TSA). Copenhagen: Copenhagen Trial Unit, Centre for Clinical Intervention Research; 2011. p. 1\u2013115."},{"key":"637_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/ije\/dyn188","volume":"38","author":"J Brok","year":"2009","unstructured":"Brok J, Thorlund K, Wetterslev J, Gluud C. Apparently conclusive meta-analyses may be inconclusive - trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol. 2009;38:287\u201398.","journal-title":"Int J Epidemiol"},{"key":"637_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1600-051X.2004.00500.x","volume":"31","author":"RM Scarel-Caminaga","year":"2004","unstructured":"Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, Camargo LE, Line SR. Interleukin 10 gene promoter polymorphisms are associated with chronic periodontitis. J Clin Periodontol. 2004;31:443\u20138.","journal-title":"J Clin Periodontol"},{"key":"637_CR25","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1177\/154405910508401211","volume":"84","author":"P Brett","year":"2005","unstructured":"Brett P, Zygogianni P, Griffiths G, Tomaz M, Parkar M, D\u2019Aiuto F, et al. Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res. 2005;84:1149\u201353.","journal-title":"J Dent Res"},{"key":"637_CR26","first-page":"CR510","volume":"13","author":"E Mellati","year":"2007","unstructured":"Mellati E, Arab HR, Tavakkol-Afshari J, Ebadian AR, Radvar M. Analysis of \u22121082 IL-10 gene polymorphism in Iranian patients with generalized aggressive periodontitis. Med Sci Monit. 2007;13:CR510\u20134.","journal-title":"Med Sci Monit"},{"key":"637_CR27","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1189\/jlb.0308184","volume":"84","author":"M Claudino","year":"2008","unstructured":"Claudino M, Trombone AP, Cardoso CR, Ferreira SB Jr, Martins W Jr, Assis GF, et al. The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome. J Leukoc Biol. 2008;84:1565\u201373.","journal-title":"J Leukoc Biol"},{"key":"637_CR28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-0765.2007.00992.x","volume":"43","author":"S Reichert","year":"2008","unstructured":"Reichert S, Machulla H, Klapproth J, Zimmermann U, Reichert Y, Gl\u00e4ser C, et al. The interleukin-10 promoter haplotype ATA is a putative risk factor for aggressive periodontitis. J Periodontal Res. 2008;43:40\u20137.","journal-title":"J Periodontal Res"},{"key":"637_CR29","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1600-0765.2008.01116.x","volume":"44","author":"K Hu","year":"2009","unstructured":"Hu K, Huang K, Ho Y, Lin Y, Ho K, Wu Y, et al. Interleukin-10 (\u2212592 C\/A) and interleukin-12B ( 16974 A\/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. J Periodontal Res. 2009;44:378\u201385.","journal-title":"J Periodontal Res"},{"key":"637_CR30","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2174\/1874210600903010184","volume":"3","author":"PR Moreira","year":"2009","unstructured":"Moreira PR, Costa JE, Gomez RS, Gollob KJ, Dutra WO. TNFA and IL10 gene polymorphisms are not associated with periodontitis in Brazilians. Open Dent J. 2009;3:184\u201390.","journal-title":"Open Dent J"},{"key":"637_CR31","first-page":"955","volume":"26","author":"C Gurol","year":"2011","unstructured":"Gurol C, Kazazoglu E, Dabakoglu B, Korachi M. A comparative study of the role of cytokine polymorphisms interleukin-10 and tumor necrosis factor alpha in susceptibility to implant failure and chronic periodontitis. Int J Oral Maxillofac Implants. 2011;26:955\u201360.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"637_CR32","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.humimm.2012.04.009","volume":"73","author":"A Atanasovska-Stojanovska","year":"2012","unstructured":"Atanasovska-Stojanovska A, Trajkov D, Popovska M, Spiroski M. IL10 -1082, IL10 -819 and IL10 -592 polymorphisms are associated with chronic periodontitis in a Macedonian population. Hum Immunol. 2012;73:753\u20138.","journal-title":"Hum Immunol"},{"key":"637_CR33","first-page":"23","volume":"5","author":"Z Heidari","year":"2013","unstructured":"Heidari Z, Hooshmand B, Hajilooi M, Kadkhodazadeh M. Study of IL-10, IL-18 polymorphisms in the sulfur agent patients with and without periodontitis. J Periodontol Implant. Dent. 2013;5:23\u20138.","journal-title":"J Periodontol Implant. Dent"},{"key":"637_CR34","doi-asserted-by":"publisher","first-page":"e569","DOI":"10.4317\/medoral.19823","volume":"19","author":"L Chambrone","year":"2014","unstructured":"Chambrone L, Ascarza A, Guerrero ME, Pannuti C, de la Rosa M, Salinas-Prieto E, et al. Association of \u22121082 interleukin-10 gene polymorphism in Peruvian adults with chronic periodontitis. Med Oral Patol Oral Cir Bucal. 2014;19:e569\u201373.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"637_CR35","doi-asserted-by":"publisher","first-page":"17828","DOI":"10.4238\/2015.December.22.7","volume":"14","author":"R Hannum","year":"2015","unstructured":"Hannum R, Godoy FR, da Cruz AZ, Vieira TC, Minasi LB, de Silva D, de Silva CC, et al. Lack of association between IL-10 -1082G\/A polymorphism and chronic periodontal disease in adults. Genet Mol Res. 2015;14:17828\u201333.","journal-title":"Genet Mol Res"},{"issue":"1","key":"637_CR36","doi-asserted-by":"publisher","first-page":"26051","DOI":"10.3402\/jom.v7.26051","volume":"7","author":"Zahra Armingohar","year":"2015","unstructured":"Zahra A, Jorgensen JJ, Kristoffersen KSk AK, Zlatko D. Polymorphisms in the interleukin-10 gene and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases. J Oral Microbiol. 2015;7:1. https:\/\/doi.org\/10.3402\/jom.v7.26051 .","journal-title":"Journal of Oral Microbiology"},{"key":"637_CR37","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1590\/1807-3107BOR-2016.vol30.0105","volume":"30","author":"VR Silveira","year":"2016","unstructured":"Silveira VR, Pigossi SC, Scarel-Caminaga RM, Cirelli JA, Rego R, Nogueira NA. Analysis of polymorphisms in interleukin 10, NOS2A, and ESR2 genes in chronic and aggressive periodontitis. Braz Oral Res. 2016;30:e105.","journal-title":"Braz Oral Res"},{"key":"637_CR38","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2741\/e802","volume":"9","author":"CB Lopes","year":"2017","unstructured":"Lopes CB, Barroso RFF, Burbano RMR, Garcia PA, Pinto PDDC, Santos NPCD, et al. Effect of ancestry on interleukin-10 haplotypes in chronic periodontitis. Front Biosci (Elite Ed). 2017;9:276\u201385.","journal-title":"Front Biosci (Elite Ed)"},{"key":"637_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4103\/1735-3327.223614","volume":"15","author":"B Moudi","year":"2018","unstructured":"Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Moudi M. Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls. Dent Res J. 2018;15:71\u20139.","journal-title":"Dent Res J"},{"key":"637_CR40","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1034\/j.1600-051X.2002.290905.x","volume":"29","author":"JR Gonzales","year":"2002","unstructured":"Gonzales JR, Michel J, Diete A, Herrmann J, B\u00f6deker R, Meyle J. Analysis of genetic polymorphisms at the interleukin-10 loci in aggressive and chronic periodontitis. J Clin Periodontol. 2002;29:816\u201322.","journal-title":"J Clin Periodontol"},{"key":"637_CR41","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1902\/jop.2006.050315","volume":"77","author":"N Babel","year":"2006","unstructured":"Babel N, Cherepnev G, Babel D, Tropmann A, Hammer M, Volk H, et al. Analysis of tumor necrosis factor-\u03b1, transforming growth factor-\u03b2, Interleukin-10, IL-6, and interferon-\u03b3 gene polymorphisms in patients with chronic periodontitis. J Periodontol. 2006;77:1978\u201383.","journal-title":"J Periodontol"},{"key":"637_CR42","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1902\/jop.2007.060309","volume":"78","author":"AP Sumer","year":"2007","unstructured":"Sumer AP, Kara N, Keles GC, Gunes S, Koprulu H, Bagci H. Association of Interleukin-10 gene polymorphisms with severe generalized chronic periodontitis. J Periodontol. 2007;78:493\u20137.","journal-title":"J Periodontol"},{"key":"637_CR43","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1600-051X.2007.01067.x","volume":"34","author":"T Tervonen","year":"2007","unstructured":"Tervonen T, Raunio T, Knuuttila M, Karttunen R. Polymorphisms in the CD14 and IL-6 genes associated with periodontal disease. J Clin Periodontol. 2007;34:377\u201383.","journal-title":"J Clin Periodontol"},{"key":"637_CR44","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/j.1600-0765.2007.01034.x","volume":"43","author":"M Cullinan","year":"2008","unstructured":"Cullinan M, Westerman B, Hamlet S, Palmer J, Faddy M, Seymour G, et al. Progression of periodontal disease and interleukin-10 gene polymorphism. J Periodontal Res. 2008;43:328\u201333.","journal-title":"J Periodontal Res"},{"key":"637_CR45","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1902\/jop.2009.080573","volume":"80","author":"T Kobayashi","year":"2009","unstructured":"Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, et al. Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. J Periodontol. 2009;80:792\u20139.","journal-title":"J Periodontol"},{"key":"637_CR46","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1177\/00220345010800080301","volume":"80","author":"ML Laine","year":"2001","unstructured":"Laine ML, Farr\u00e9 MA, Gonz\u00e1lez G, van Dijk LJ, Ham AJ, Winkel EG. Polymorphisms of the interleukin-1 gene family, oral microbial pathogens, and smoking in adult periodontitis. J Dent Res. 2001;80:1695\u20139.","journal-title":"J Dent Res"},{"issue":"Suppl 2","key":"637_CR47","first-page":"S197","volume":"9","author":"L Scapoli","year":"2012","unstructured":"Scapoli L, Girardi A, Palmieri A, et al. IL6 and IL10 are genetic susceptibility factors of periodontal disease. Dental Res J. 2012;9(Suppl 2):S197\u2013201.","journal-title":"Dental Res J"},{"key":"637_CR48","doi-asserted-by":"publisher","first-page":"387","DOI":"10.4103\/1305-7456.163237","volume":"9","author":"J Crena","year":"2015","unstructured":"Crena J, Subramanian S, Victor DJ, Gnana PPS, Ramanathan A. Single nucleotide polymorphism at \u22121087 locus of interleukin-10 gene promoter is associated with severe chronic periodontitis in nonsmoking patients. Eur J Dent. 2015;9:387\u201393.","journal-title":"Eur J Dent"},{"key":"637_CR49","doi-asserted-by":"crossref","unstructured":"Pirim Gorgun E, Toker H, Korkmaz EM, Poyraz O. IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters. Braz. Oral Res. 2017;31.","DOI":"10.1590\/1807-3107bor-2017.vol31.0012"},{"key":"637_CR50","doi-asserted-by":"publisher","first-page":"20","DOI":"10.11138\/orl\/2017.10.1.020","volume":"10","author":"L Tettamanti","year":"2017","unstructured":"Tettamanti L, Gaudio RM, Iapichino A, Mucchi D, Tagliabue A. Genetic susceptibility and periodontal disease: a retrospective study on a large Italian sample. Oral Implantol. 2017;10:20\u20137.","journal-title":"Oral Implantol"},{"key":"637_CR51","doi-asserted-by":"publisher","first-page":"e20170232","DOI":"10.1590\/1678-7757-2017-0232","volume":"26","author":"H Toker","year":"2018","unstructured":"Toker H, Gorgun EP, Korkmaz EM, Y\u00fcce HB, Poyraz O. The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis. J Appl Oral Sci. 2018;26:e20170232.","journal-title":"J Appl Oral Sci"},{"key":"637_CR52","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1046\/j.1365-2249.2001.01448.x","volume":"123","author":"DF Lappin","year":"2001","unstructured":"Lappin DF, MacLeod CP, Kerr A, Mitchell T, Kinane DF. Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clin Exp Immunol. 2001;123:294\u2013300.","journal-title":"Clin Exp Immunol"},{"key":"637_CR53","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cyto.2012.05.014","volume":"60","author":"Q Zhong","year":"2012","unstructured":"Zhong Q, Ding C, Wang M, Sun Y, Xu Y. Interleukin-10 gene polymorphisms and chronic\/aggressive periodontitis susceptibility: a meta-analysis based on 14 case-control studies. Cytokine. 2012;60:47\u201354.","journal-title":"Cytokine"},{"key":"637_CR54","doi-asserted-by":"publisher","first-page":"9319","DOI":"10.1007\/s11033-012-1738-1","volume":"39","author":"CM Albuquerque","year":"2012","unstructured":"Albuquerque CM, Cortinhas AJ, Morinha FJ, Leitao JC, Viegas CA, Bastos EM. Association of the IL-10 polymorphisms and periodontitis: a meta-analysis. Mol Biol Rep. 2012;39:9319\u201329.","journal-title":"Mol Biol Rep"},{"key":"637_CR55","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1834-7819.1998.tb00176.x","volume":"43","author":"GC Townsend","year":"1998","unstructured":"Townsend GC, Aldred MJ, Bartold PM. Genetic aspects of dental disorders. Aust Dent J. 1998;43:269\u201386.","journal-title":"Aust Dent J"},{"key":"637_CR56","first-page":"2314","volume":"24","author":"M Lazarus","year":"1997","unstructured":"Lazarus M, Hajeer AH, Turner D, Sinnott P, Worthington J, Ollier WE, et al. Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J Rheumatol. 1997;24:2314\u20137.","journal-title":"J Rheumatol"},{"key":"637_CR57","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-2567.2006.02321.x","volume":"117","author":"A Taylor","year":"2006","unstructured":"Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-\u03b2: the role of T regulatory cells. Immunology. 2006;117:433\u201342.","journal-title":"Immunology"},{"key":"637_CR58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","volume":"160","author":"R Assuma","year":"1998","unstructured":"Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998;160:403\u20139.","journal-title":"J Immunol"},{"issue":"1, 2","key":"637_CR59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.33320\/maced.pharm.bull.2012.58.001","volume":"58","author":"L Bogdanovska","year":"2012","unstructured":"Bogdanovska L, et al. Therapeutic strategies in the treatment of periodontitis. Macedonian Pharmaceutical Bulletin. 2012;58(1, 2):3\u201314.","journal-title":"Macedonian Pharmaceutical Bulletin"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-018-0637-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12903-018-0637-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-018-0637-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T17:00:12Z","timestamp":1720717212000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-018-0637-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["637"],"URL":"https:\/\/doi.org\/10.1186\/s12903-018-0637-9","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]},"assertion":[{"value":"23 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The need for approval was waived as this study solely used published human data.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"171"}}