{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:31:43Z","timestamp":1772303503266,"version":"3.50.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12903-019-0789-2","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T14:47:14Z","timestamp":1560437234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of locally-delivered statins adjunct to non-surgical periodontal therapy for chronic periodontitis: a Bayesian network analysis"],"prefix":"10.1186","volume":"19","author":[{"given":"Ruoyan","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiulan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mianfeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"789_CR1","doi-asserted-by":"publisher","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038.","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"789_CR2","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/jcpe.12110","volume":"40","author":"F Vidal","year":"2013","unstructured":"Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol. 2013;40(7):681\u20137.","journal-title":"J Clin Periodontol"},{"issue":"10","key":"789_CR3","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/jcpe.13003","volume":"45","author":"JN Vergnes","year":"2018","unstructured":"Vergnes JN, Canceill T, Vinel A, Laurencin-Dalicieux S, Maupas-Schwalm F, Blasco-Baque V, Hanaire H, Arrive E, Rigalleau V, Nabet C, et al. The effects of periodontal treatment on diabetic patients: the DIAPERIO randomized controlled trial. J Clin Periodontol. 2018;45(10):1150\u201363.","journal-title":"J Clin Periodontol"},{"key":"789_CR4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jdent.2017.08.011","volume":"67","author":"K Bertl","year":"2017","unstructured":"Bertl K, Parllaku A, Pandis N, Buhlin K, Klinge B, Stavropoulos A. The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy-a systematic review and meta-analysis. J Dent. 2017;67:18\u201328.","journal-title":"J Dent"},{"issue":"7","key":"789_CR5","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1194\/jlr.M073882","volume":"58","author":"N Thongtang","year":"2017","unstructured":"Thongtang N, Diffenderfer MR, Ooi EMM, Barrett PHR, Turner SM, Le NA, Brown WV, Schaefer EJ. Metabolism and proteomics of large and small dense LDL in combined hyperlipidemia: effects of rosuvastatin. J Lipid Res. 2017;58(7):1315\u201324.","journal-title":"J Lipid Res"},{"issue":"3","key":"789_CR6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.jacl.2017.03.003","volume":"11","author":"I Bytyci","year":"2017","unstructured":"Bytyci I, Bajraktari G, Bhatt DL, Morgan CJ, Ahmed A, Aronow WS, Banach M, Lipid, Blood Pressure Meta-analysis Collaboration G. Hydrophilic vs lipophilic statins in coronary artery disease: a meta-analysis of randomized controlled trials. J Clin Lipidol. 2017;11(3):624\u201337.","journal-title":"J Clin Lipidol"},{"issue":"4","key":"789_CR7","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1007\/s10753-016-0390-7","volume":"39","author":"V Cicek Ari","year":"2016","unstructured":"Cicek Ari V, Ilarslan YD, Erman B, Sarkarati B, Tezcan I, Karabulut E, Oz SG, Tanriover MD, Sengun D, Berker E. Statins and IL-1beta, IL-10, and MPO levels in gingival Crevicular fluid: preliminary results. Inflammation. 2016;39(4):1547\u201357.","journal-title":"Inflammation"},{"issue":"6","key":"789_CR8","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1177\/154405910608500608","volume":"85","author":"K Sakoda","year":"2006","unstructured":"Sakoda K, Yamamoto M, Negishi Y, Liao JK, Node K, Izumi Y. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. J Dent Res. 2006;85(6):520\u20133.","journal-title":"J Dent Res"},{"key":"789_CR9","doi-asserted-by":"publisher","first-page":"16407","DOI":"10.1038\/srep16407","volume":"5","author":"S Thangamani","year":"2015","unstructured":"Thangamani S, Mohammad H, Abushahba MFN, Hamed MI, Sobreira TJP, Hedrick VE, Paul LN, Seleem MN. Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent. Sci Rep-Uk. 2015;5:16407.","journal-title":"Sci Rep-Uk"},{"issue":"5446","key":"789_CR10","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","volume":"286","author":"G Mundy","year":"1999","unstructured":"Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science (New York, NY). 1999;286(5446):1946\u20139.","journal-title":"Science (New York, NY)"},{"issue":"3","key":"789_CR11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1177\/0022034513516980","volume":"93","author":"J Jin","year":"2014","unstructured":"Jin J, Machado ER, Yu H, Zhang X, Lu Z, Li Y, Lopes-Virella MF, Kirkwood KL, Huang Y. Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. J Dent Res. 2014;93(3):294\u20139.","journal-title":"J Dent Res"},{"issue":"2","key":"789_CR12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1089\/ars.2014.6190","volume":"24","author":"J Bouitbir","year":"2016","unstructured":"Bouitbir J, Singh F, Charles AL, Schlagowski AI, Bonifacio A, Echaniz-Laguna A, Geny B, Krahenbuhl S, Zoll J. Statins trigger mitochondrial reactive oxygen species-induced apoptosis in glycolytic skeletal muscle. Antioxid Redox Sign. 2016;24(2):84\u201398.","journal-title":"Antioxid Redox Sign"},{"issue":"3","key":"789_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.4103\/0976-500X.162011","volume":"6","author":"S Khurana","year":"2015","unstructured":"Khurana S, Gupta S, Bhalla H, Nandwani S, Gupta V. Comparison of anti-inflammatory effect of atorvastatin with rosuvastatin in patients of acute coronary syndrome. J Pharmacol Pharmacother. 2015;6(3):130\u20135.","journal-title":"J Pharmacol Pharmacother"},{"issue":"1","key":"789_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/FJC.0b013e3181bfb1df","volume":"55","author":"Y Su","year":"2010","unstructured":"Su Y, Xu Y, Sun YM, Li J, Liu XM, Li YB, Liu GD, Bi S. Comparison of the effects of simvastatin versus atorvastatin on oxidative stress in patients with type 2 diabetes mellitus. J Cardiovasc Pharmacol. 2010;55(1):21\u20135.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"789_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.autrev.2017.10.013","volume":"17","author":"GM Li","year":"2018","unstructured":"Li GM, Zhao J, Li B, Zhang XF, Ma JX, Ma XL, Liu J. The anti-inflammatory effects of statins on patients with rheumatoid arthritis: a systemic review and meta-analysis of 15 randomized controlled trials. Autoimmun Rev. 2018;17(3):215\u201325.","journal-title":"Autoimmun Rev"},{"issue":"1","key":"789_CR16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/eos.12239","volume":"124","author":"M Ting","year":"2016","unstructured":"Ting M, Whitaker EJ, Albandar JM. Systematic review of the in vitro effects of statins on oral and perioral microorganisms. Eur J Oral Sci. 2016;124(1):4\u201310.","journal-title":"Eur J Oral Sci"},{"issue":"4","key":"789_CR17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1902\/jop.2016.160384","volume":"88","author":"K Sinjab","year":"2017","unstructured":"Sinjab K, Zimmo N, Lin GH, Chung MP, Shaikh L, Wang HL. The effect of locally delivered statins on treating periodontal Intrabony defects: a systematic review and meta-analysis. J Periodontol. 2017;88(4):357\u201367.","journal-title":"J Periodontol"},{"issue":"2","key":"789_CR18","doi-asserted-by":"publisher","first-page":"e12304","DOI":"10.1111\/jicd.12304","volume":"9","author":"Zohaib Akram","year":"2017","unstructured":"Akram Z, Vohra F, Javed F. Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta-analysis. J Investig Clin Dent. 2018;9(2):e12304.","journal-title":"Journal of Investigative and Clinical Dentistry"},{"issue":"1","key":"789_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/jre.12480","volume":"53","author":"LMB Ambrosio","year":"2018","unstructured":"Ambrosio LMB, Rovai ES, Sendyk DI, Holzhausen M, Pannuti CM. Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta-analysis. J Periodontal Res. 2018;53(1):12\u201321.","journal-title":"J Periodontal Res"},{"issue":"2","key":"789_CR20","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00784-018-2354-9","volume":"22","author":"F Muniz","year":"2018","unstructured":"Muniz F, Taminski K, Cavagni J, Celeste RK, Weidlich P, Rosing CK. The effect of statins on periodontal treatment-a systematic review with meta-analyses and meta-regression. Clin Oral Investig. 2018;22(2):671\u201387.","journal-title":"Clin Oral Investig"},{"issue":"7","key":"789_CR21","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1007\/s00784-018-2507-x","volume":"22","author":"J Meza-Mauricio","year":"2018","unstructured":"Meza-Mauricio J, Soto-Penaloza D, Penarrocha-Oltra D, Montiel-Company JM, Peruzzo DC. Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis. Clin Oral Investig. 2018;22(7):2413\u201330.","journal-title":"Clin Oral Investig"},{"issue":"2","key":"789_CR22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.14306\/renhyd.20.2.223","volume":"20","author":"D Moher","year":"2016","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, Grp P-P. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Rev Esp Nutr Hum Die. 2016;20(2):148\u201360.","journal-title":"Rev Esp Nutr Hum Die"},{"key":"789_CR23","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions; 2011."},{"issue":"1","key":"789_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-051X.2009.01499.x","volume":"37","author":"YK Tu","year":"2010","unstructured":"Tu YK, Woolston A, Faggion CM Jr. Do bone grafts or barrier membranes provide additional treatment effects for infrabony lesions treated with enamel matrix derivatives? A network meta-analysis of randomized-controlled trials. J Clin Periodontol. 2010;37(1):59\u201379.","journal-title":"J Clin Periodontol"},{"issue":"7\u20138","key":"789_CR25","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/sim.3767","volume":"29","author":"S Dias","year":"2010","unstructured":"Dias S, Welton NJ, Caldwell DM, Ades AE. Checking consistency in mixed treatment comparison meta-analysis. Stat Med. 2010;29(7\u20138):932\u201344.","journal-title":"Stat Med"},{"key":"789_CR26","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/1467-9868.00353","volume":"64","author":"DJ Spiegelhalter","year":"2002","unstructured":"Spiegelhalter DJ, Best NG, Carlin BR, van der Linde A. Bayesian measures of model complexity and fit. J R Stat Soc Ser B Stat Methodol. 2002;64:583\u2013616.","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"789_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41598-017-00051-9","volume":"7","author":"XJ Zhao","year":"2017","unstructured":"Zhao XJ, Zhou CC, Ma JJ, Zhu YJ, Sun M, Wang PX, Zhang Y, Ma HQ, Zhang HJ. Efficacy and safety of rectal 5-aminosalicylic acid versus corticosteroids in active distal ulcerative colitis: a systematic review and network meta-analysis. Sci Rep-Uk. 2017;7:15.","journal-title":"Sci Rep-Uk"},{"key":"789_CR28","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1902\/jop.2009.090429","volume":"81","author":"AR Pradeep","year":"2010","unstructured":"Pradeep AR, Thorat MS. Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial. J Periodontol. 2010;81:214\u201322.","journal-title":"J Periodontol"},{"key":"789_CR29","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1902\/jop.2012.110716","volume":"83","author":"AR Pradeep","year":"2012","unstructured":"Pradeep AR, Priyanka N, Kalra N, Naik SB, Singh SP, Martande S. Clinical efficacy of subgingivally delivered 1.2-mg simvastatin in the treatment of individuals with class II furcation defects: a randomized controlled clinical trial. J Periodontol. 2012;83:1472\u20139.","journal-title":"J Periodontol"},{"issue":"1","key":"789_CR30","first-page":"70","volume":"4","author":"A Rath","year":"2012","unstructured":"Rath A, Mahenra J, Thomas L, Sandhu M, Namasi A, Ramakrishna T. A clinical, radiological and IL-6 evaluation of subgingivally delivered simvastatin in the treatment of chronic periodontitis. Int J Drug Deliv. 2012;4(1):70\u201381.","journal-title":"Int J Drug Deliv"},{"key":"789_CR31","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1902\/jop.2012.120393","volume":"84","author":"AR Pradeep","year":"2013","unstructured":"Pradeep AR, Kumari M, Rao NS, Martande SS, Naik SB. Clinical efficacy of subgingivally delivered 1.2% atorvastatin in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2013;84:871\u20139.","journal-title":"J Periodontol"},{"key":"789_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1902\/jop.2012.110721","volume":"84","author":"AR Pradeep","year":"2013","unstructured":"Pradeep AR, Rao NS, Bajaj P, Kumari M. Efficacy of subgingivally delivered simvastatin in the treatment of patients with type 2 diabetes and chronic periodontitis: a randomized double-masked controlled clinical trial. J Periodontol. 2013;84:24\u201331.","journal-title":"J Periodontol"},{"key":"789_CR33","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/adj.12042","volume":"58","author":"NS Rao","year":"2013","unstructured":"Rao NS, Pradeep AR, Bajaj P, Kumari M, Naik SB. Simvastatin local drug delivery in smokers with chronic periodontitis: a randomized controlled clinical trial. Aust Dent J. 2013;58:156\u201362.","journal-title":"Aust Dent J"},{"key":"789_CR34","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1902\/jop.2015.140631","volume":"86","author":"AR Pradeep","year":"2015","unstructured":"Pradeep AR, Karvekar S, Nagpal K, Patnaik K, Guruprasad CN, Kumaraswamy KM. Efficacy of locally delivered 1.2% rosuvastatin gel to non-surgical treatment of patients with chronic periodontitis: a randomized, placebo-controlled clinical trial. J Periodontol. 2015;86:738\u201345.","journal-title":"J Periodontol"},{"issue":"11","key":"789_CR35","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1902\/jop.2016.130227","volume":"87","author":"M Kumari","year":"2016","unstructured":"Kumari M, Martande SS, Pradeep AR, Naik SB. Efficacy of Subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. J Periodontol. 2016;87(11):1278\u201385.","journal-title":"J Periodontol"},{"issue":"7","key":"789_CR36","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1902\/jop.2016.150706","volume":"87","author":"AR Pradeep","year":"2016","unstructured":"Pradeep AR, Garg V, Kanoriya D, Singhal S. 1.2% Rosuvastatin versus 1.2% atorvastatin gel local drug delivery and redelivery in treatment of Intrabony defects in chronic periodontitis: a randomized placebo-controlled clinical trial. J Periodontol. 2016;87(7):756\u201362.","journal-title":"J Periodontol"},{"issue":"3","key":"789_CR37","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1902\/jop.2016.160399","volume":"88","author":"S Garg","year":"2017","unstructured":"Garg S, Pradeep AR. 1.2% Rosuvastatin and 1.2% atorvastatin gel local drug delivery and redelivery in the treatment of class II furcation defects: a randomized controlled clinical trial. J Periodontol. 2017;88(3):259\u201365.","journal-title":"J Periodontol"},{"issue":"2","key":"789_CR38","doi-asserted-by":"publisher","first-page":"e12213","DOI":"10.1111\/jicd.12213","volume":"8","author":"Minal Kumari","year":"2016","unstructured":"Kumari M, Martande SS, Pradeep AR. Subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis among smokers: a randomized, controlled clinical trial. J Investig Clin Dent. 2017;8(2). https:\/\/doi.org\/10.1111\/jicd.12213 .","journal-title":"Journal of Investigative and Clinical Dentistry"},{"issue":"3","key":"789_CR39","doi-asserted-by":"publisher","first-page":"e12215","DOI":"10.1111\/jicd.12215","volume":"8","author":"Avani R. Pradeep","year":"2016","unstructured":"Pradeep AR, Kanoriya D, Singhal S, Garg V, Manohar B, Chatterjee A. Comparative evaluation of subgingivally delivered 1% alendronate versus 1.2% atorvastatin gel in treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. J Investig Clin Dent. 2017;8(3). https:\/\/doi.org\/10.1111\/jicd.12215 .","journal-title":"Journal of Investigative and Clinical Dentistry"},{"issue":"1","key":"789_CR40","doi-asserted-by":"publisher","first-page":"18","DOI":"10.15171\/joddd.2017.004","volume":"11","author":"S S Martande","year":"2017","unstructured":"S Martande S, Kumari M, Pradeep AR, Pal Singh S, Kumar Suke D. Comparative evaluation of efficacy of subgingivally delivered 1.2% atorvastatin and 1.2% simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial. J Dent Res Dent Clin Dent Prospects. 2017;11(1):18\u201325.","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"issue":"11","key":"789_CR41","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1002\/JPER.17-0434","volume":"89","author":"D Pankaj","year":"2018","unstructured":"Pankaj D, Sahu I, Kurian IG, Pradeep AR. Comparative evaluation of subgingivally delivered 1.2% rosuvastatinand 1% metformin gelin treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2018;89(11):1318\u201325.","journal-title":"J Periodontol"},{"issue":"9","key":"789_CR42","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1902\/jop.2016.150306","volume":"87","author":"SS Martande","year":"2016","unstructured":"Martande SS, Kumari M, Pradeep AR, Singh SP, Suke DK, Guruprasad CN. Platelet-rich fibrin combined with 1.2% atorvastatin for treatment of Intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2016;87(9):1039\u201346.","journal-title":"J Periodontol"},{"issue":"3","key":"789_CR43","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1601-0825.2011.01880.x","volume":"18","author":"O Fentoglu","year":"2012","unstructured":"Fentoglu O, Kirzioglu FY, Ozdem M, Kocak H, Sutcu R, Sert T. Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment. Oral Dis. 2012;18(3):299\u2013306.","journal-title":"Oral Dis"},{"key":"789_CR44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1515\/dmpt-2015-0024","volume":"30","author":"SM Surve","year":"2015","unstructured":"Surve SM, Acharya AB, Thakur SL. Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing. Drug Metab Pers Ther. 2015;30:263\u20139.","journal-title":"Drug Metab Pers Ther"},{"issue":"3","key":"789_CR45","doi-asserted-by":"publisher","first-page":"377","DOI":"10.4103\/0976-237X.137959","volume":"5","author":"S Emani","year":"2014","unstructured":"Emani S, Gunjiganur GV, Mehta DS. Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: an in vitro study. Contemp Clin Dent. 2014;5(3):377\u201382.","journal-title":"Contemp Clin Dent"},{"issue":"5","key":"789_CR46","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1161\/01.ATV.0000068646.76823.AE","volume":"23","author":"Z Luan","year":"2003","unstructured":"Luan Z, Chase AJ, Newby AC. Statins inhibit secretion of metalloproteinases-1, \u22122, \u22123, and \u22129 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol. 2003;23(5):769\u201375.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"789_CR47","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/S0006-291X(03)01408-6","volume":"308","author":"CL Song","year":"2003","unstructured":"Song CL, Guo ZQ, Ma QJ, Chen ZQ, Liu ZJ, Jia HT, Dang GT. Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells. Biochem Bioph Res Co. 2003;308(3):458\u201362.","journal-title":"Biochem Bioph Res Co"},{"issue":"3","key":"789_CR48","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/jcb.20074","volume":"92","author":"T Maeda","year":"2004","unstructured":"Maeda T, Matsunuma A, Kurahashi I, Yanagawa T, Yoshida H, Horiuchi N. Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells. J Cell Biochem. 2004;92(3):458\u201371.","journal-title":"J Cell Biochem"},{"issue":"4","key":"789_CR49","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.jval.2011.04.002","volume":"14","author":"JP Jansen","year":"2011","unstructured":"Jansen JP, Fleurence R, Devine B, Itzler R, Barrett A, Hawkins N, Lee K, Boersma C, Annemans L, Cappelleri JC. Interpreting indirect treatment comparisons and network meta-analysis for health-care decision making: report of the ISPOR task force on indirect treatment comparisons good research practices: part 1. Value Health. 2011;14(4):417\u201328.","journal-title":"Value Health"},{"issue":"3","key":"789_CR50","doi-asserted-by":"publisher","first-page":"820","DOI":"10.3390\/ijms19030820","volume":"19","author":"Chandong Jeong","year":"2018","unstructured":"Jeong C, Kim SE, Shim KS, Kim HJ, Song MH, Park K, Song HR. Exploring the in vivo anti-inflammatory actions of simvastatin-loaded porous microspheres on inflamed tenocytes in a collagenase-induced animal model of Achilles tendinitis. Int J Mol Sci. 2018;19(3). https:\/\/doi.org\/10.3390\/ijms19030820 .","journal-title":"International Journal of Molecular Sciences"},{"issue":"8","key":"789_CR51","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1902\/jop.2012.120114","volume":"84","author":"R Dalcico","year":"2013","unstructured":"Dalcico R, de Menezes AM, Deocleciano OB, Oria RB, Vale ML, Ribeiro RA, Brito GA. Protective mechanisms of simvastatin in experimental periodontal disease. J Periodontol. 2013;84(8):1145\u201357.","journal-title":"J Periodontol"},{"issue":"4","key":"789_CR52","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.bcp.2014.09.026","volume":"92","author":"YJ Chen","year":"2014","unstructured":"Chen YJ, Chang LS. Simvastatin induces NFkappaB\/p65 down-regulation and JNK1\/c-Jun\/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells. Biochem Pharmacol. 2014;92(4):530\u201343.","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"789_CR53","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/jre.12442","volume":"52","author":"MR Messora","year":"2017","unstructured":"Messora MR, Apolinario Vieira GH, Vanderlei J, Mariguela VC, Fernandes PG, Palioto DB, Scombatti de Souza SL, Novaes AB Jr, Furlaneto F, Taba M Jr. Rosuvastatin promotes benefits on induced periodontitis in hypertensive rats. J Periodontal Res. 2017;52(4):734\u201344.","journal-title":"J Periodontal Res"},{"issue":"1","key":"789_CR54","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/prd.12089","volume":"69","author":"SK Sonnenschein","year":"2015","unstructured":"Sonnenschein SK, Meyle J. Local inflammatory reactions in patients with diabetes and periodontitis. Periodontology 2000. 2015;69(1):221\u201354.","journal-title":"Periodontology 2000"},{"issue":"2","key":"789_CR55","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/jcpe.12803","volume":"45","author":"D Polak","year":"2018","unstructured":"Polak D, Shapira L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 2018;45(2):150\u201366.","journal-title":"J Clin Periodontol"},{"issue":"7","key":"789_CR56","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1902\/jop.2005.76.7.1171","volume":"76","author":"J Katz","year":"2005","unstructured":"Katz J, Caudle RM, Bhattacharyya I, Stewart CM, Cohen DM. Receptor for advanced glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine. J Periodontol. 2005;76(7):1171\u20134.","journal-title":"J Periodontol"},{"issue":"4","key":"789_CR57","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1902\/jop.2007.060381","volume":"78","author":"J Katz","year":"2007","unstructured":"Katz J, Yoon TY, Mao S, Lamont RJ, Caudle RM. Expression of the receptor of advanced glycation end products in the gingival tissue of smokers with generalized periodontal disease and after nornicotine induction in primary gingival epithelial cells. J Periodontol. 2007;78(4):736\u201341.","journal-title":"J Periodontol"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-019-0789-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12903-019-0789-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-019-0789-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T18:05:16Z","timestamp":1721412316000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-019-0789-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["789"],"URL":"https:\/\/doi.org\/10.1186\/s12903-019-0789-2","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"19 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"105"}}