{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:09:59Z","timestamp":1780387799035,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Kikuchi-Fujimoto disease, known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting and systemic disorder involving lymph nodes with unknown aetiology. First reported in Japan, there has been an increase in its incidence globally. Because of its non-specific clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a high rate of misdiagnosis and mistreatment, posing a considerable challenge.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A case of young Chinese woman with fever and cervical lymphadenopathy is presented. Physical examinations and imaging techniques were used to rule out common forms of lymphadenitis (e.g. cat-scratch disease and tuberculous lymphadenitis). Laboratory tests were then conducted to exclude others such as systemic lupus erythematosus and non-Hodgkin lymphoma. After Kikuchi-Fujimoto disease was identified, the patient was managed with symptomatic treatments. Our case was compared with relevant cases in the literature. A diagnostic flow chart was proposed to facilitate the diagnosis and treatment.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>With its shared clinical features, Kikuchi-Fujimoto disease can be mistaken for other forms of lymphadenitis. A combined use of medical imaging and laboratory tests is the effective way to avoid misdiagnosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-019-0920-4","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T12:49:47Z","timestamp":1571662187000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures"],"prefix":"10.1186","volume":"19","author":[{"given":"Shenjie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"920_CR1","first-page":"378","volume":"35","author":"M Kikuchi","year":"1972","unstructured":"Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia. Nippon Ketsueki Gakkai Zasshi. 1972;35:378\u201380.","journal-title":"Nippon Ketsueki Gakkai Zasshi"},{"key":"920_CR2","first-page":"920","volume":"20","author":"Y Fujimoto","year":"1972","unstructured":"Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological agent. Naika. 1972;20:920\u20137.","journal-title":"Naika"},{"key":"920_CR3","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.5858\/arpa.2018-0219-RA","volume":"142","author":"AM Perry","year":"2018","unstructured":"Perry AM, Choi SM. Kikuchi-Fujimoto disease: A review. Arch Pathol Lab Med. 2018;142:1341\u20136.","journal-title":"Arch Pathol Lab Med"},{"key":"920_CR4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1067\/mhn.2001.120431","volume":"125","author":"AL Ramirez","year":"2001","unstructured":"Ramirez AL, Johnson J, Murr AH. Kikuchi-Fujimoto\u2019s disease: an easily misdiagnosed clinical entity. Otolaryngol Head Neck Surg. 2001;125:651\u20133.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"920_CR5","first-page":"1","volume":"31","author":"J Lahma","year":"2018","unstructured":"Lahma J, Arkoubi Z, Hejjouji R, Nitassi S, El Ayoubi A, Bencheikh R, et al. About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto\u2019s disease. Pan Afr Med J. 2018;31:1\u20135.","journal-title":"Pan Afr Med J"},{"key":"920_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1309\/YF081L4TKYWVYVPQ","volume":"122","author":"X Bosch","year":"2004","unstructured":"Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. 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