{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:19:05Z","timestamp":1772165945124,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have reported the efficacy and safety of intravenous (IV) iron therapy during the perioperative period as an alternative and adjunct to allogeneic blood transfusion. Preemptive IV iron therapy provides noninferior hemoglobin levels on postoperative day (POD) 1 compared to autologous whole blood therapy (AWBT) in healthy patients who had undergone bimaxillary orthognathic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective, patient-randomized, noninferiority trial. After excluding 2 patients, 64 patients were divided into two groups: the IV iron therapy group (patients received IV iron infusion 4\u00a0weeks before surgery;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932) and the AWBT group (2 units of autologous whole blood were collected 4 and 2\u00a0weeks before surgery;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932). The primary outcome was hemoglobin level on POD 1 and the prespecified noninferiority limit was \u2212\u20091\u00a0g\/dL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline data were comparable, including hemoglobin and iron levels, between the two groups. Immediately before surgery, the levels of hemoglobin, iron, and ferritin were higher in the IV iron group than in the AWBT group. The mean treatment difference (iron group\u2014whole blood group) in hemoglobin level on POD 1 between the two groups was 0.09 (95% CI\u2009=\u2009\u2212\u20090.83 to 1.0). As the lower limit of the 95% CI (\u2212\u20090.83) was higher than the prespecified noninferiority margin (\u03b4\u2009=\u2009\u2212\u20091), noninferiority was established. On POD 2, the hemoglobin level became lower in the iron group, which eventually led to greater requirement of allogeneic blood transfusion compared to the whole blood group. However, the iron group did not require allogeneic blood transfusion during or early after surgery, and the whole blood group showed continuously higher incidence of overt iron deficiency compared to the iron group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As collection of autologous whole blood caused overt iron loss and anemia before surgery and intraoperative transfusion of whole blood was not able to prevent the occurrence of persistent iron deficiency after surgery, IV iron therapy was found to have potential benefits for iron homeostasis and subsequent erythropoiesis in healthy patients early after bimaxillary orthognathic surgery.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration<\/jats:italic>\n                      : Clinical Research Information Service, Republic of Korea, approval number: KCT0003680 on March 27, 2019.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cris.nih.go.kr\/cris\/search\/search_result_st01_kren.jsp?seq=15769&amp;sLeft=2&amp;ltype=my&amp;rtype=my\">https:\/\/cris.nih.go.kr\/cris\/search\/search_result_st01_kren.jsp?seq=15769&amp;sLeft=2&amp;ltype=my&amp;rtype=my<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-020-01359-1","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T09:03:57Z","timestamp":1610010237000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preemptive intravenous iron therapy versus autologous whole blood therapy for early postoperative hemoglobin level in patients undergoing bimaxillary orthognathic surgery: a prospective randomized noninferiority trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Min Suk","family":"Chae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Uk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-2652","authenticated-orcid":false,"given":"Young Eun","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"issue":"8","key":"1359_CR1","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/0278-2391(95)90273-2","volume":"53","author":"JE Moenning","year":"1995","unstructured":"Moenning JE, Bussard DA, Lapp TH, Garrison BT. Average blood loss and the risk of requiring perioperative blood transfusion in 506 orthognathic surgical procedures. J Oral Maxillofac Surgery. 1995;53(8):880\u20133.","journal-title":"J Oral Maxillofac Surgery"},{"issue":"4","key":"1359_CR2","first-page":"221","volume":"7","author":"BR Neuwirth","year":"1992","unstructured":"Neuwirth BR, White RP Jr, Collins ML, Phillips C. Recovery following orthognathic surgery and autologous blood transfusion. Int J Adult Orthodont Orthognathic Surg. 1992;7(4):221\u20138.","journal-title":"Int J Adult Orthodont Orthognathic Surg"},{"issue":"3","key":"1359_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0278-2391(85)90160-0","volume":"43","author":"RD Marciani","year":"1985","unstructured":"Marciani RD, Dickson LG. Autologous transfusion in orthognathic surgery. J Oral Maxillofac Surg. 1985;43(3):201\u20134.","journal-title":"J Oral Maxillofac Surg"},{"issue":"12","key":"1359_CR4","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.ijom.2010.09.003","volume":"39","author":"J Ervens","year":"2010","unstructured":"Ervens J, Marks C, Hechler M, Plath T, Hansen D, Hoffmeister B. Effect of induced hypotensive anaesthesia vs isovolaemic haemodilution on blood loss and transfusion requirements in orthognathic surgery: a prospective, single-blinded, randomized, controlled clinical study. Int J Oral Maxillofac Surg. 2010;39(12):1168\u201374.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"4","key":"1359_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2106\/JBJS.L.01041","volume":"96","author":"ET Newman","year":"2014","unstructured":"Newman ET, Watters TS, Lewis JS, Jennings JM, Wellman SS, Attarian DE, Grant SA, Green CL, Vail TP, Bolognesi MP. Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty. J Bone Joint Surg Am. 2014;96(4):279\u201384.","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"1359_CR6","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/ejcts\/ezt661","volume":"46","author":"DV Avgerinos","year":"2014","unstructured":"Avgerinos DV, DeBois W, Salemi A. Blood conservation strategies in cardiac surgery: more is better. Eur J Cardio-thoracic Surg. 2014;46(5):865\u201370.","journal-title":"Eur J Cardio-thoracic Surg"},{"issue":"8","key":"1359_CR7","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1111\/trf.13659","volume":"56","author":"RG Cable","year":"2016","unstructured":"Cable RG, Brambilla D, Glynn SA, Kleinman S, Mast AE, Spencer BR, Stone M, Kiss JE. Effect of iron supplementation on iron stores and total body iron after whole blood donation. Transfusion. 2016;56(8):2005\u201312.","journal-title":"Transfusion"},{"issue":"6","key":"1359_CR8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/jama.2015.119","volume":"313","author":"JE Kiss","year":"2015","unstructured":"Kiss JE, Brambilla D, Glynn SA, Mast AE, Spencer BR, Stone M, Kleinman SH, Cable RG. Oral iron supplementation after blood donation: a randomized clinical trial. JAMA. 2015;313(6):575\u201383.","journal-title":"JAMA"},{"issue":"5","key":"1359_CR9","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/bjh.15136","volume":"181","author":"JE Kiss","year":"2018","unstructured":"Kiss JE, Vassallo RR. How do we manage iron deficiency after blood donation? Br J Haematol. 2018;181(5):590\u2013603.","journal-title":"Br J Haematol"},{"issue":"11","key":"1359_CR10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1097\/EJA.0b013e32834ad97b","volume":"28","author":"P Piednoir","year":"2011","unstructured":"Piednoir P, Allou N, Driss F, Longrois D, Philip I, Beaumont C, Montravers P, Lasocki S. Preoperative iron deficiency increases transfusion requirements and fatigue in cardiac surgery patients: a prospective observational study. Eur J Anaesthesiol. 2011;28(11):796\u2013801.","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"1359_CR11","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1046\/j.1537-2995.2000.40040457.x","volume":"40","author":"P Toy","year":"2000","unstructured":"Toy P, Feiner J, Viele MK, Watson J, Yeap H, Weiskopf RB. Fatigue during acute isovolemic anemiain healthy, resting humans. Transfusion. 2000;40(4):457\u201360.","journal-title":"Transfusion"},{"issue":"7","key":"1359_CR12","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3748\/wjg.v20.i7.1852","volume":"20","author":"HM Yoon","year":"2014","unstructured":"Yoon HM, Kim YW, Nam BH, Reim D, Eom BW, Park JY, Ryu KW. Intravenous iron supplementation may be superior to observation in acute isovolemic anemia after gastrectomy for cancer. World J Gastroenterol. 2014;20(7):1852\u20137.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1359_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s40265-014-0332-3","volume":"75","author":"GM Keating","year":"2015","unstructured":"Keating GM. Ferric carboxymaltose: a review of its use in iron deficiency. Drugs. 2015;75(1):101\u201327.","journal-title":"Drugs"},{"issue":"1","key":"1359_CR14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1537-2995.2010.02769.x","volume":"51","author":"JA Serrano-Trenas","year":"2011","unstructured":"Serrano-Trenas JA, Ugalde PF, Cabello LM, Chofles LC, Lazaro PS, Benitez PC. Role of perioperative intravenous iron therapy in elderly hip fracture patients: a single-center randomized controlled trial. Transfusion. 2011;51(1):97\u2013104.","journal-title":"Transfusion"},{"issue":"25","key":"1359_CR15","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","volume":"361","author":"SD Anker","year":"2009","unstructured":"Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, L\u00fcscher TF, Bart B, Banasiak W, Niegowska J, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361(25):2436\u201348.","journal-title":"N Engl J Med"},{"issue":"2","key":"1359_CR16","first-page":"236","volume":"21","author":"RI Usmanov","year":"2008","unstructured":"Usmanov RI, Zueva EB, Silverberg DS, Shaked M. Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. J Nephrol. 2008;21(2):236\u201342.","journal-title":"J Nephrol"},{"issue":"3","key":"1359_CR17","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1423-0410.2007.01014.x","volume":"94","author":"M Munoz","year":"2008","unstructured":"Munoz M, Breymann C, Garcia-Erce JA, Gomez-Ramirez S, Comin J, Bisbe E. Efficacy and safety of intravenous iron therapy as an alternative\/adjunct to allogeneic blood transfusion. Vox Sang. 2008;94(3):172\u201383.","journal-title":"Vox Sang"},{"issue":"3","key":"1359_CR18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/anae.14569","volume":"74","author":"D Mayhew","year":"2019","unstructured":"Mayhew D, Mendonca V, Murthy BVS. A review of ASA physical status\u2014historical perspectives and modern developments. Anaesthesia. 2019;74(3):373\u20139.","journal-title":"Anaesthesia"},{"issue":"2","key":"1359_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/ALN.0000000000000463","volume":"122","author":"Practice guidelines for perioperative blood management","year":"2015","unstructured":"Practice guidelines for perioperative blood management. an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management*. Anesthesiology. 2015;122(2):241\u201375.","journal-title":"Anesthesiology"},{"issue":"9","key":"1359_CR20","doi-asserted-by":"publisher","first-page":"e5493","DOI":"10.1590\/1414-431x20165493","volume":"49","author":"J Zhou","year":"2016","unstructured":"Zhou J. A review of the application of autologous blood transfusion. Braz J Med Biol Res. 2016;49(9):e5493.","journal-title":"Braz J Med Biol Res"},{"key":"1359_CR21","doi-asserted-by":"publisher","first-page":"100593","DOI":"10.1016\/j.blre.2019.100593","volume":"38","author":"EK Storch","year":"2019","unstructured":"Storch EK, Custer BS, Jacobs MR, Menitove JE, Mintz PD. Review of current transfusion therapy and blood banking practices. Blood Rev. 2019;38:100593.","journal-title":"Blood Rev"},{"issue":"1","key":"1359_CR22","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s12288-017-0842-8","volume":"34","author":"J Zhou","year":"2018","unstructured":"Zhou J, Chen Z, Jin J, Zhang QL. A study of preoperative autologous blood donation timing. Indian J Hematol Blood Transf. 2018;34(1):138\u201342.","journal-title":"Indian J Hematol Blood Transf"},{"issue":"2","key":"1359_CR23","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jcms.2015.11.012","volume":"44","author":"HJ Park","year":"2016","unstructured":"Park HJ, Park JU, Yoo W, Moon YE. Analgesic effects of nefopam in patients undergoing bimaxillary osteotomy: a double-blind, randomized, placebo-controlled study. J Cranio-Maxillo-Facial Surg. 2016;44(2):210\u20134.","journal-title":"J Cranio-Maxillo-Facial Surg"},{"issue":"2","key":"1359_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santiba\u00f1es E, Pekolj J, Slankamenac K, Bassi C, et al. The Clavien\u2013Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187\u201396.","journal-title":"Ann Surg"},{"issue":"24","key":"1359_CR25","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1001\/jama.2012.87802","volume":"308","author":"G Piaggio","year":"2012","unstructured":"Piaggio G, Elbourne DR, Pocock SJ, Evans SJ, Altman DG. Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA. 2012;308(24):2594\u2013604.","journal-title":"JAMA"},{"key":"1359_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-7196-1_1","volume":"1646","author":"RA Bonar","year":"2017","unstructured":"Bonar RA, Lippi G, Favaloro EJ. Overview of hemostasis and thrombosis and contribution of laboratory testing to diagnosis and management of hemostasis and thrombosis disorders. Methods Mol Biol (Clifton). 2017;1646:3\u201327.","journal-title":"Methods Mol Biol (Clifton)"},{"issue":"6","key":"1359_CR27","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.jacc.2006.07.015","volume":"48","author":"AP Bolger","year":"2006","unstructured":"Bolger AP, Bartlett FR, Penston HS, O\u2019Leary J, Pollock N, Kaprielian R, Chapman CM. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. J Am Coll Cardiol. 2006;48(6):1225\u20137.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1359_CR28","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/ejcts\/ezu200","volume":"47","author":"M Hogan","year":"2015","unstructured":"Hogan M, Klein AA, Richards T. The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery. Eur J Cardio-thoracic Surg. 2015;47(2):218\u201326.","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"1359_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13643-015-0016-4","volume":"4","author":"AM Elhenawy","year":"2015","unstructured":"Elhenawy AM, Meyer SR, Bagshaw SM, MacArthur RG, Carroll LJ. Role of preoperative intravenous iron therapy to correct anemia before major surgery: study protocol for systematic review and meta-analysis. Syst Rev. 2015;4:29.","journal-title":"Syst Rev"},{"issue":"20","key":"1359_CR30","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1001\/jama.2017.5703","volume":"317","author":"YW Kim","year":"2017","unstructured":"Kim YW, Bae JM, Park YK, Yang HK, Yu W, Yook JH, Noh SH, Han M, Ryu KW, Sohn TS, et al. Effect of intravenous ferric carboxymaltose on hemoglobin response among patients with acute isovolemic anemia following gastrectomy: The FAIRY randomized clinical trial. JAMA. 2017;317(20):2097\u2013104.","journal-title":"JAMA"},{"issue":"8","key":"1359_CR31","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1097\/00003246-200008000-00015","volume":"28","author":"CE van Iperen","year":"2000","unstructured":"van Iperen CE, Gaillard CA, Kraaijenhagen RJ, Braam BG, Marx JJ, van de Wiel A. Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Crit Care Med. 2000;28(8):2773\u20138.","journal-title":"Crit Care Med"},{"issue":"9","key":"1359_CR32","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1093\/ndt\/gfw264","volume":"32","author":"SD Roger","year":"2017","unstructured":"Roger SD, Gaillard CA, Bock AH, Carrera F, Eckardt KU, Van Wyck DB, Cronin M, Meier Y, Larroque S, Macdougall IC. Safety of intravenous ferric carboxymaltose versus oral iron in patients with nondialysis-dependent CKD: an analysis of the 1-year FIND-CKD trial. Nephrol Dialysis Transpl. 2017;32(9):1530\u20139.","journal-title":"Nephrol Dialysis Transpl"},{"issue":"8","key":"1359_CR33","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jbmr.1923","volume":"28","author":"M Wolf","year":"2013","unstructured":"Wolf M, Koch TA, Bregman DB. Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. J Bone Min Res. 2013;28(8):1793\u2013803.","journal-title":"J Bone Min Res"},{"issue":"1","key":"1359_CR34","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1310\/hpj4901-52","volume":"49","author":"DJ Cada","year":"2014","unstructured":"Cada DJ, Levien TL, Baker DE. Ferric carboxymaltose. Hosp Pharm. 2014;49(1):52\u20139.","journal-title":"Hosp Pharm"},{"issue":"4","key":"1359_CR35","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.ijom.2015.11.008","volume":"45","author":"AY Oh","year":"2016","unstructured":"Oh AY, Seo KS, Lee GE, Kim HJ. Effect of preoperative autologous blood donation on patients undergoing bimaxillary orthognathic surgery: a retrospective analysis. Int J Oral Maxillofac Surg. 2016;45(4):486\u20139.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"1359_CR36","first-page":"102","volume":"1","author":"SM Lahsaee","year":"2013","unstructured":"Lahsaee SM, Ghaffaripour S, Hejr H. The effect of routine maintenance intravenous therapy on hemoglobin concentration and hematocrit during anesthesia in adults. Bull Emerg Trauma. 2013;1(3):102\u20137.","journal-title":"Bull Emerg Trauma"},{"issue":"7","key":"1359_CR37","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.joms.2008.01.060","volume":"66","author":"W Kretschmer","year":"2008","unstructured":"Kretschmer W, Koster U, Dietz K, Zoder W, Wangerin K. Factors for intraoperative blood loss in bimaxillary osteotomies. J Oral Maxillofac Surg. 2008;66(7):1399\u2013403.","journal-title":"J Oral Maxillofac Surg"},{"key":"1359_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bcmd.2017.10.006","volume":"70","author":"DA Gell","year":"2018","unstructured":"Gell DA. Structure and function of haemoglobins. Blood Cells Mol Dis. 2018;70:13\u201342.","journal-title":"Blood Cells Mol Dis"},{"issue":"9","key":"1359_CR39","first-page":"2889","volume":"7","author":"MY Long","year":"2014","unstructured":"Long MY, Liu ZH, Zhu JG. Comparative analysis of autologous blood transfusion and allogeneic blood transfusion in surgical patients. Int J Clin Exp Med. 2014;7(9):2889\u201394.","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"1359_CR40","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00264-013-2185-x","volume":"38","author":"S Jakovina Blazekovic","year":"2014","unstructured":"Jakovina Blazekovic S, Bicanic G, Hrabac P, Tripkovic B, Delimar D. Pre-operative autologous blood donation versus no blood donation in total knee arthroplasty: a prospective randomised trial. Int Orthop. 2014;38(2):341\u20136.","journal-title":"Int Orthop"},{"issue":"6","key":"1359_CR41","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/MOH.0000000000000284","volume":"23","author":"PC Spinella","year":"2016","unstructured":"Spinella PC, Cap AP. Whole blood: back to the future. Curr Opin Hematol. 2016;23(6):536\u201342.","journal-title":"Curr Opin Hematol"},{"issue":"5","key":"1359_CR42","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/bjaceaccp\/mkl042","volume":"6","author":"A Walunj","year":"2006","unstructured":"Walunj A, Babb A, Sharpe R. Autologous blood transfusion. Continuing Educ Anaesth Crit Care Pain. 2006;6(5):192\u20136.","journal-title":"Continuing Educ Anaesth Crit Care Pain"},{"issue":"1","key":"1359_CR43","doi-asserted-by":"publisher","first-page":"15853","DOI":"10.1038\/s41598-020-72827-5","volume":"10","author":"B Lee","year":"2020","unstructured":"Lee B, Kim EJ, Song J, Jung YS, Koo BN. A randomised trial evaluating the effect of intraoperative iron administration. Sci Rep. 2020;10(1):15853.","journal-title":"Sci Rep"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-020-01359-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12903-020-01359-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-020-01359-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T15:13:44Z","timestamp":1610032424000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-020-01359-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1359"],"URL":"https:\/\/doi.org\/10.1186\/s12903-020-01359-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-64923\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-64923\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-64923\/v2","asserted-by":"object"}]},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]},"assertion":[{"value":"24 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This was a prospective, patient-randomized, noninferiority trial. The protocol was approved by the Institutional Review Board of Seoul St. Mary\u2019s Hospital Ethics Committee (Approval No. KC18MESI0583) on December 19, 2018. The study was performed in accordance with the principles of the Declaration of Helsinki. The study protocol was prospectively registered at a publicly accessible clinical registration site that is recognized by the International Committee of Medical Journal Editors (Clinical Research Information Service, Republic of Korea, approval number: KCT0003680) on March 27, 2019. Written informed consent was obtained from all patients at our hospital who were enrolled between March 2019 and May 2020. The study adhered to the Consolidated Standards of Reporting Trials (CONSORT) guidelines (Additional file\n                      \n                      ) and a CONSORT flow chart is provided in Fig.\u00a0\n                      \n                      . Additional file\n                      \n                      presents a summary of our study protocol.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}