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This study investigated the association between\n                      <jats:italic>VDR<\/jats:italic>\n                      gene polymorphisms and the risk of OLP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In total, 177 OLP patients and 207 healthy participants were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) in the\n                      <jats:italic>VDR<\/jats:italic>\n                      gene were selected and genotyped.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted Odd ratio(OR)\u2009=\u20092.68, 95% Confidence interval(CI)\u2009=\u20091.28\u20135.62,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009) and rs7975232 CC genotype (Recessive model: adjusted OR\u2009=\u20092.25, 95% CI\u2009=\u20091.10\u20134.58,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.026). Moreover, rs2239185 and rs7975232 (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u00a00.01) showed significant cumulative effects on OLP risk.Haplotype analysis showed that the CC haplotype (rs2239185-rs7975232) was associated with an increased risk of OLP (OR\u2009=\u20093.11, 95% CI\u2009=\u20091.42\u20136.83,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005), compared with the AC haplotype.\n                    <\/jats:p>\n                    <jats:p>\n                      Conclusion: The rs2239185 and rs7975232 variants of\n                      <jats:italic>VDR<\/jats:italic>\n                      may influence OLP susceptibility, and\n                      <jats:italic>VDR<\/jats:italic>\n                      gene polymorphisms may be candidate susceptibility regions for OLP in a Chinese Han population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-020-1002-3","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T10:03:38Z","timestamp":1580378618000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population"],"prefix":"10.1186","volume":"20","author":[{"given":"Hong","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-5401","authenticated-orcid":false,"given":"Rongbin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"issue":"3","key":"1002_CR1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4103\/0019-5154.156315","volume":"60","author":"S Gupta","year":"2015","unstructured":"Gupta S, Jawanda MK. 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