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The present meta-analysis was therefore designed to formally assess the relationship between rs13041247 and NSCL\/P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Embase, Web of Science, PubMed, the China National Knowledge Internet (CNKI), and the China Wanfang database in order to identify relevant published through 25 June 2019. This allowed us to identify 13 studies incorporating 4914 patients and 5981 controls for whom rs13041247 genotyping had been conducted, with STATA 12.0 then being used to conduct a meta-analysis of these pooled results. The I<jats:sup>2<\/jats:sup>statistic was used to compare heterogeneity among studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total this analysis incorporated 13 case-control studies. No association between the rs13041247 polymorphism and NSCL\/P risk was detected in individuals of Asian ethnicity (C vs T: OR\u2009=\u20090.847, 95% CI\u2009=\u20090.702\u20131.021; CC vs TT: OR\u2009=\u20090.725, 95% CI\u2009=\u20090.494\u20131.063; CC vs CT: OR\u2009=\u20090.837, 95% CI\u2009=\u20090.657\u20131.067; CT\u2009+\u2009TT vs CC: OR\u2009=\u20091.265, 95% CI\u2009=\u20090.951\u20131.684; CC\u2009+\u2009CT vs TT: OR\u2009=\u20090.805, 95% CI\u2009=\u20090.630\u20131.029) or Caucasian ethnicity (C vs T: OR\u2009=\u20090.936, 95% CI\u2009=\u20090.786\u20131.114; CC vs TT: OR\u2009=\u20090.988, 95% CI\u2009=\u20090.674\u20131.446; CC vs CT: OR\u2009=\u20091.197, 95% CI\u2009=\u20090.816\u20131.757; CT\u2009+\u2009TT vs CC: OR\u2009=\u20090.918, 95% CI\u2009=\u20090.639\u20131.318; CC\u2009+\u2009CT vs TT: OR\u2009=\u20090.855, 95% CI\u2009=\u20090.677\u20131.081). However, an overall analysis of all participants in these studies revealed the rs13041247 C allele, the CT genotype, and the CC\u2009+\u2009CT model to be linked to a reduced NSCL\/P risk (C vs T: OR\u2009=\u20090.897, 95% CI: 0.723\u20131.114,<jats:italic>P<\/jats:italic>\u2009=\u20090.048; CT vs TT: OR\u2009=\u20090.839, 95% CI: 0.734\u20130.959,<jats:italic>P<\/jats:italic>\u2009=\u20090.01; CC\u2009+\u2009CT vs TT: OR\u2009=\u20090.824, 95% CI: 0.701\u20130.968,<jats:italic>P<\/jats:italic>\u2009=\u20090.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that the rs13041247 SNP located at the 20q12 chromosomal locus is associated with NSCL\/P risk in an overall pooled study population, although this association was not significant in East Asian or Caucasian populations.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12903-020-1003-2","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:06:45Z","timestamp":1612310805000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between 20q12 rs13041247 polymorphism and risk of nonsyndromic cleft lip with or without cleft palate: a meta-analysis"],"prefix":"10.1186","volume":"20","author":[{"given":"Liheng","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinglong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangzhan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9849-2925","authenticated-orcid":false,"given":"Yunpu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"issue":"4","key":"1003_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1053\/jpdn.2000.8148","volume":"15","author":"PL Bender","year":"2000","unstructured":"Bender PL. 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