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Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 <jats:italic>gene<\/jats:italic> may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I<jats:sup>2<\/jats:sup>) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg\u2019 and Egger\u2019s test with Comprehensive meta-analysis software. The value of <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered as significant.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Five studies were identified in diverse ethnical groups with 1425 participants. The \u2212\u2009330\u2009T\/G polymorphism in IL2 <jats:italic>gene<\/jats:italic> was not significantly associated with CP in allelic evaluation (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) as well as in the genotypic comparisons (<jats:italic>P<\/jats:italic>\u2009=\u20090.15). The Begg\u2019s test and the linear regression Egger\u2019s test did not show any evidence of publication bias risk (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This meta-analysis showed a non-significant association between \u2212\u2009330\u2009T\/G polymorphism in IL2 <jats:italic>gene<\/jats:italic> and CP in any allelic evaluation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12903-020-1034-8","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T13:03:25Z","timestamp":1582117405000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Non-significant association between \u2212\u2009330\u2009T\/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-5571","authenticated-orcid":false,"given":"Felipe Rodolfo Pereira","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Gomes","family":"Galeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Luiz Ara\u00fajo Bentes","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyce Santos","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayana Yared","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silv\u00e2nia","family":"da Concei\u00e7\u00e3o Furtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Fernando Pereira","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Diniz","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Fernando Marques","family":"Barcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"1034_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/prd.12110","volume":"71","author":"ET Knight","year":"2016","unstructured":"Knight ET, Liu J, Seymour GJ, et al. 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