{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:51:16Z","timestamp":1793242276103,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This study investigated the remineralisation effect of bioactive glass on artificial dentine caries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide\u2013amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28\u2009days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (\u0394VHN, mean\u2009\u00b1\u2009SD) after pH cycling were 9.67\u2009\u00b1\u20093.60, 6.06\u2009\u00b1\u20093.83, 5.00\u2009\u00b1\u20092.19 and\u2009\u2212\u20091.90\u2009\u00b1\u20092.09 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean\u2009\u00b1\u2009SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165\u2009\u00b1\u200911\u2009\u03bcm, 111\u2009\u00b1\u200911\u2009\u03bcm, 75\u2009\u00b1\u20096\u2009\u03bcm and 0\u2009\u03bcm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-020-1038-4","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T16:02:50Z","timestamp":1581436970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Remineralising effect of 45S5 bioactive glass on artificial caries in dentine"],"prefix":"10.1186","volume":"20","author":[{"given":"Qiong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-4576","authenticated-orcid":false,"given":"May Lei","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Hung","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"issue":"3","key":"1038_CR1","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jdent.2010.12.004","volume":"39","author":"C Rocha Gomes Torres","year":"2011","unstructured":"Rocha Gomes Torres C, Borges AB, Torres LM, Gomes IS, de Oliveira RS. 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This study was conducted in full accordance with the Declaration of Helsinki of the World Medical Association. All participants received dental treatment at the Hospital of Stomatology of Nanjing Medical University and provided written informed consent. The written consents were obtained from the parents\/guardians of the teenagers who were under 16\u2009years of age.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"49"}}