{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:05:33Z","timestamp":1793693133312,"version":"4.5.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients using antiplatelet drugs following infarctions, acute coronary syndrome or stroke pose a significant clinical problem if it is necessary to perform surgery, including dental surgery, since they are at risk of prolonged or secondary post-extraction bleeding. Discontinuation of this therapy is associated with a high risk of serious thromboembolic complications. The purpose of this study was to assess the effectiveness of TachoSil fibrin-collagen patches in stopping and preventing of secondary post-extraction bleeding in patients undergoing chronic antiplatelet therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was conducted through retrospective examination of the medical records of 153 patients using chronic antiplatelet therapy and those qualified for tooth extraction. The largest group comprised 74 patients using aspirin and clopidogrel as dual platelet antiaggregation therapy; in this group 75 tooth extractions were carried out. In all of the patients TachoSil fibrin-collagen patches and stiches were applied to the wounds resulting from tooth removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following tooth extraction, primary bleeding was stopped in all the patients and their wounds closed via coagulation within 20\u201330\u00a0min. In eight cases, accounting for 4.9% of the patients, secondary bleeding occurred and was successfully stopped only by applying a pressure dressing soaked in tranexamic acid. Secondary bleeding occurred in three patients on the second day and in five patients on the third day following tooth removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Topical application of TachoSil patches following tooth removal in patients using single or dual antiplatelet therapy effectively stopped bleeding and prevented secondary bleeding after tooth extraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-021-01391-9","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T05:03:05Z","timestamp":1610686985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Analysing the effectiveness of topical bleeding care following tooth extraction in patients receiving dual antiplatelet therapy-retrospective observational study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8045-5093","authenticated-orcid":false,"given":"Bogumi\u0142","family":"Lewandowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Myszka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Migut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Czenczek-Lewandowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Brodowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"1391_CR1","first-page":"687","volume":"47","author":"M Abayon","year":"2016","unstructured":"Abayon M, Kolokythas A, Siu H, Elad S. Dental management of patients on direct oral anticoagulants: case series and literature review. Quintessence Int (Berl). 2016;47:687\u201396.","journal-title":"Quintessence Int (Berl)"},{"key":"1391_CR2","first-page":"e123","volume":"134","author":"GN Levine","year":"2016","unstructured":"Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, et al. 2016 ACC\/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Thorac Cardiovasc Surg. 2016;134:e123\u201355.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1391_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5125\/jkaoms.2018.44.4.143","volume":"44","author":"JK Lee","year":"2018","unstructured":"Lee JK. Dental management of patients on anti-thrombotic agents. J Korean Assoc Oral Maxillofac Surg. 2018;44:143\u201350.","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"1391_CR4","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1016\/j.oooo.2016.06.003","volume":"122","author":"C Mauprivez","year":"2016","unstructured":"Mauprivez C, Khonsari RH, Razouk O, Goudot P, Lesclous P, Descroix V. Management of dental extraction in patients undergoing anticoagulant oral direct treatment: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:e146\u201355.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1391_CR5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5603\/KP.2016.0014","volume":"74","author":"P Pruszczyk","year":"2016","unstructured":"Pruszczyk P, Ciurzy\u0144ski M, Opolski G, St\u0119pi\u0144ska J, Wo\u017cakowska-Kap\u0142on B, Kalarus Z, et al. Dental cardio common position for dealing anticoagulation in patients undergoing dental procedures. Kardiol Pol. 2016;74:87.","journal-title":"Kardiol Pol"},{"key":"1391_CR6","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2018.4.02","author":"A Undas","year":"2018","unstructured":"Undas A, Zabczyk M. Antithrombotic medications and their impact on fibrin clot structure and function. J Physiol Pharmacol. 2018. https:\/\/doi.org\/10.26402\/jpp.2018.4.02.","journal-title":"J Physiol Pharmacol"},{"key":"1391_CR7","doi-asserted-by":"publisher","first-page":"442","DOI":"10.5603\/FC.2018.0112","volume":"13","author":"B Wo\u017cakowska-Kap\u0142on","year":"2018","unstructured":"Wo\u017cakowska-Kap\u0142on B. Tikagrelor lekiem przeciwp\u0142ytkowym pierwszego wyboru w ostrym zespole wie\u0144cowym. Czy w Polsce s\u0105 realizowane wytyczne terapii przeciwp\u0142ytkowej u chorych z ACS? Folia Cardiol. 2018;13:442\u20139.","journal-title":"Folia Cardiol"},{"key":"1391_CR8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.adaj.2017.09.052","volume":"149","author":"O Doganay","year":"2018","unstructured":"Doganay O, Atalay B, Karadag E, Aga U, Tugrul M. Bleeding frequency of patients taking ticagrelor, aspirin, clopidogrel, and dual antiplatelet therapy after tooth extraction and minor oral surgery. J Am Dent Assoc. 2018;149:132\u20138.","journal-title":"J Am Dent Assoc"},{"key":"1391_CR9","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.coms.2016.06.003","volume":"28","author":"AE Ghantous","year":"2016","unstructured":"Ghantous AE, Ferneini EM. Aspirin, plavix, and other antiplatelet medications: what the oral and maxillofacial surgeon needs to know. Oral Maxillofac Surg Clin N Am. 2016;28:497\u2013506.","journal-title":"Oral Maxillofac Surg Clin N Am"},{"key":"1391_CR10","doi-asserted-by":"publisher","first-page":"823651","DOI":"10.1155\/2015\/823651","volume":"2015","author":"A Gr\u00f6be","year":"2015","unstructured":"Gr\u00f6be A, Fraederich M, Smeets R, Heiland M, Kluwe L, Zeuch J, et al. Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. Biomed Res Int. 2015;2015:823651.","journal-title":"Biomed Res Int"},{"key":"1391_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.adaj.2015.01.002","volume":"146","author":"HR Omar","year":"2015","unstructured":"Omar HR, Socias SM, Powless RA, Sprenker C, Karlnoski R, Mangar D, et al. Clopidogrel is not associated with increased bleeding complications after full-mouth extraction: a retrospective study. J Am Dent Assoc. 2015;146:303\u20139.","journal-title":"J Am Dent Assoc"},{"key":"1391_CR12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/ccd.ccd_702_17","volume":"9","author":"P Babaji","year":"2018","unstructured":"Babaji P, Rishal Y. Clinical evaluation of role of dual antiplatelet therapy on bleeding after dental extraction. Contemp Clin Dent. 2018;9:41\u20134.","journal-title":"Contemp Clin Dent"},{"key":"1391_CR13","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1378\/chest.13-0459","volume":"144","author":"S Darvish-Kazem","year":"2013","unstructured":"Darvish-Kazem S, Gandhi M, Marcucci M, Douketis JD. Perioperative management of antiplatelet therapy in patients with a coronary stent who need noncardiac surgery: a systematic review of clinical practice guidelines. Chest. 2013;144:1848\u201356.","journal-title":"Chest"},{"key":"1391_CR14","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.amjcard.2011.05.029","volume":"108","author":"T Lillis","year":"2011","unstructured":"Lillis T, Ziakas A, Koskinas K, Tsirlis A, Giannoglou G. Safety of dental extractions during uninterrupted single or dual antiplatelet treatment. Am J Cardiol. 2011;108:964\u20137.","journal-title":"Am J Cardiol"},{"key":"1391_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/bja\/aeq003","volume":"104","author":"A Oscarsson","year":"2010","unstructured":"Oscarsson A, Gupta A, Fredrikson M, Jarhult J, Nystrom M, Pettersson E, et al. To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial. Br J Anaesth. 2010;104:305\u201312.","journal-title":"Br J Anaesth"},{"key":"1391_CR16","doi-asserted-by":"publisher","first-page":"E24","DOI":"10.1038\/sj.bdj.2014.1055","volume":"217","author":"N Patel","year":"2014","unstructured":"Patel N, Patel V, Sarkar D, Nokes T, Blacklock P. Dual anti-platelet therapy and dento-alveolar surgery. How do we manage patients on anti-platelet medication? Br Dent J. 2014;217:E24.","journal-title":"Br Dent J"},{"key":"1391_CR17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1600-0501.2010.01963.x","volume":"22","author":"C Bacci","year":"2011","unstructured":"Bacci C, Berengo M, Favero L, Zanon E. Safety of dental implant surgery in patients undergoing anticoagulation therapy: a prospective case-control study. Clin Oral Implants Res. 2011;22:151\u20136.","journal-title":"Clin Oral Implants Res"},{"key":"1391_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1834-7819.2003.tb00019.x","volume":"48","author":"PD Cannon","year":"2003","unstructured":"Cannon PD, Dharmar VT. Minor oral surgical procedures in patients on oral anticoagulants: a controlled study. Aust Dent J. 2003;48:115\u20138.","journal-title":"Aust Dent J"},{"key":"1391_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijom.2013.08.014","volume":"43","author":"C Girotra","year":"2014","unstructured":"Girotra C, Padhye M, Mandlik G, Dabir A, Gite M, Dhonnar R, et al. Assessment of the risk of haemorrhage and its control following minor oral surgical procedures in patients on anti-platelet therapy: a prospective study. Int J Oral Maxillofac Surg. 2014;43:99\u2013106.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1391_CR20","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.adaj.2015.04.024","volume":"146","author":"WH Schreuder","year":"2015","unstructured":"Schreuder WH, Peacock ZS. Antiplatelet therapy and exodontia. J Am Dent Assoc. 2015;146:851\u20136.","journal-title":"J Am Dent Assoc."},{"key":"1391_CR21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.oooo.2012.11.001","volume":"115","author":"JJ Nape\u00f1as","year":"2013","unstructured":"Nape\u00f1as JJ, Oost FCD, Degroot A, Loven B, Hong CHL, Brennan MT, et al. Review of postoperative bleeding risk in dental patients on antiplatelet therapy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:491\u20139.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1391_CR22","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00784-019-03080-y","volume":"24","author":"R Pippi","year":"2020","unstructured":"Pippi R. Effectiveness of local hemostatic measures after tooth extraction in patients on antithrombotic therapy. Clin Oral Investig. 2020;24:515.","journal-title":"Clin Oral Investig"},{"key":"1391_CR23","doi-asserted-by":"publisher","DOI":"10.4172\/Interventional-Cardiology.1000569","author":"J Papanikolaou","year":"2017","unstructured":"Papanikolaou J, Platogiannis N, Gkekas D, Barmpatzas N, Spathoulas K, Platogiannis D. Discontinuation of prolonged dual antiplatelet therapy for a dental extraction; a nearly-fatal decision. Interv Cardiol. 2017. https:\/\/doi.org\/10.4172\/Interventional-Cardiology.1000569.","journal-title":"Interv Cardiol"},{"key":"1391_CR24","doi-asserted-by":"publisher","first-page":"8402","DOI":"10.12968\/denu.2015.42.9.840","volume":"42","author":"S Johnston","year":"2015","unstructured":"Johnston S. A new generation of antiplatelet and anticoagulant medication and the implications for the dental surgeon. Dent Update. 2015;42:8402\u201356.","journal-title":"Dent Update."},{"key":"1391_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.4103\/0970-9290.162893","volume":"26","author":"K George Varghese","year":"2015","unstructured":"George Varghese K, Manoharan S, Sadhanandan M. Evaluation of bleeding following dental extraction in patients on long-term antiplatelet therapy: a clinical trial. Indian J Dent Res. 2015;26:252\u20135.","journal-title":"Indian J Dent Res"},{"key":"1391_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/SLA.0000000000002279","volume":"267","author":"JA Columbo","year":"2018","unstructured":"Columbo JA, Lambour AJ, Sundling RA, Chauhan NB, Bessen SY, Linshaw DL, et al. A meta-analysis of the impact of aspirin, clopidogrel, and dual antiplatelet therapy on bleeding complications in noncardiac surgery. Ann Surg. 2018;267:1\u201310.","journal-title":"Ann Surg"},{"key":"1391_CR27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1080\/13814788.2017.1350645","volume":"23","author":"CA D\u00e9zsi","year":"2017","unstructured":"D\u00e9zsi CA, D\u00e9zsi BB, D\u00e9zsi AD. Management of dental patients receiving antiplatelet therapy or chronic oral anticoagulation: a review of the latest evidence. Eur J Gen Pract. 2017;23:196\u2013201.","journal-title":"Eur J Gen Pract"},{"key":"1391_CR28","first-page":"e2398","volume":"10","author":"G Gupta","year":"2018","unstructured":"Gupta G, Muthusekhar MR, Kumar SP. Efficacy of hemocoagulase as a topical hemostatic agent after dental extractions: a systematic review. Cureus. 2018;10:e2398.","journal-title":"Cureus"},{"key":"1391_CR29","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1007\/s00784-018-2576-x","volume":"23","author":"A Ockerman","year":"2019","unstructured":"Ockerman A, Miclotte I, Vanhaverbeke M, Verhamme P, Poortmans LL, Vanassche T, et al. Local haemostatic measures after tooth removal in patients on antithrombotic therapy: a systematic review. Clin Oral Investig. 2019;23:1695\u2013708.","journal-title":"Clin Oral Investig"},{"key":"1391_CR30","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.2147\/TCRM.S172591","volume":"14","author":"JMDM Borges","year":"2018","unstructured":"Borges JMDM, de Carvalho FO, Gomes IA, Rosa MB, Sousa ACS. Antiplatelet agents in perioperative noncardiac surgeries: to maintain or to suspend? Ther Clin Risk Manag. 2018;14:1887\u201395.","journal-title":"Ther Clin Risk Manag"},{"key":"1391_CR31","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.oooo.2015.01.004","volume":"119","author":"B Zhao","year":"2015","unstructured":"Zhao B, Wang P, Dong Y, Zhu Y, Zhao H. Should aspirin be stopped before tooth extraction? A meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:522\u201330.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1391_CR32","doi-asserted-by":"publisher","first-page":"771","DOI":"10.14219\/jada.archive.2012.0266","volume":"143","author":"BV Bajkin","year":"2012","unstructured":"Bajkin BV, Bajkin IA, Petrovic BB. The effects of combined oral anticoagulant-aspirin therapy in patients undergoing tooth extractions: a prospective study. J Am Dent Assoc. 2012;143:771\u20136.","journal-title":"J Am Dent Assoc"},{"key":"1391_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jds.2018.10.001","volume":"14","author":"D Owattanapanich","year":"2019","unstructured":"Owattanapanich D, Ungprasert P, Owattanapanich W. Efficacy of local tranexamic acid treatment for prevention of bleeding after dental procedures: a systematic review and meta-analysis. J Dent Sci. 2019;14:21\u20136.","journal-title":"J Dent Sci"},{"issue":"10","key":"1391_CR34","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.ijom.2016.02.010","volume":"45","author":"SY Lu","year":"2016","unstructured":"Lu SY, Tsai CY, Lin LH, Lu SN. Dental extraction without stopping single or dual antiplatelet therapy: results of a retrospective cohort study. Int J Oral Maxillofac Surg. 2016;45(10):1293\u20138.","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-021-01391-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12903-021-01391-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-021-01391-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T16:10:18Z","timestamp":1697559018000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-021-01391-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1391"],"URL":"https:\/\/doi.org\/10.1186\/s12903-021-01391-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-59397\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-59397\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-59397\/v1","asserted-by":"object"}]},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"13 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided written informed consent for participation in this research programme, which was approved by the Ethics Committee of the University of Rzeszow (Poland).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not concern.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31"}}