{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:38:07Z","timestamp":1793925487821,"version":"4.8.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2020-2-4103"],"award-info":[{"award-number":["2020-2-4103"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n (\u2212)-Epigallocatechin Gallate (EGCG) as green tea catechins possessed antibacterial and anti-inflammatory effects on periodontal disease. This study was designed to evaluate the clinical and microbiological efficacy of scaling and root planing (SRP) using EGCG aqueous solution as coolants through a new-type ultrasonic scaler tip on chronic periodontitis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This split-mouth, randomized clinical trial included 20 patients (2 drop-outs) with chronic periodontitis and the maxillary contra-lateral sides were allocated into test and control groups randomly. Through the new-type scaler tip, 762 sites with probing depth (PD)\u2009\u2265\u20094\u00a0mm were treated by SRP using EGCG solution or distilled water as coolants respectively. Clinical parameters and red complex pathogens in subgingival microbiome were evaluated at baseline, 3 and 6\u00a0months after treatments.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During 6\u00a0months, the SRP plus EGCG medication contributed to additional PD reduction as 0.33\u00a0mm and gain of clinical attachment level as 0.3\u00a0mm compared with SRP alone, and approximate 8% more sites obtained PD reduction\u2009\u2265\u20092\u00a0mm (\n p<\/jats:italic>\n \u2009<\u20090.05). Meanwhile, the mean relative abundance of\n Tannerella forsythia<\/jats:italic>\n was significantly lower in the combined treatment group (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The purified EGCG showed the potential to improve the outcome of periodontal non-surgical treatment and the new-type scaler tip provided an alternative vehicle for subgingival medication.<\/jats:p>\n \n Trial registration<\/jats:italic>\n The trial was registered in Chinese Clinical Trial Registry on 15 February 2020 (No.: ChiCTR2000029831, retrospectively registered).\n http:\/\/www.chictr.org.cn\/showprojen.aspx?proj=49441<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12903-021-01418-1","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T06:40:36Z","timestamp":1613803236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of (\u2212)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Yanfeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxian","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"issue":"1","key":"1418_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/prd.12147","volume":"76","author":"A Mombelli","year":"2018","unstructured":"Mombelli A. 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All procedures involving human participants were conducted in accordance with the Helsinki Declaration of 1975, as revised in 2013. All individual participants provided written informed consent before enrolled in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dr. Luan has an issued patent the new-type scaler tip (ZL201820316091.3) without licensed to any company or royalties obtained. Other authors claim no conflict of interest related to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}