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The aim of this study was to investigate the response of oral cancer cells in the biological characteristics evoked by the\n                      <jats:italic>S. anginosus and investigate its potential mechanisms.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The growth curve and concentration standard curve of\n                      <jats:italic>S. anginosus<\/jats:italic>\n                      were determined, and a series of concentrations of\n                      <jats:italic>S. anginosus<\/jats:italic>\n                      supernatant\u00a0were applied to OSCC cell lines SCC15, then selected an optimal time and concentration by CCK-8 assay. Then autophagic response, proliferative activity, cell cycle and apoptosis, invasion and migration abilities were evaluated in SCC15.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that when the ratio of\n                      <jats:italic>S. anginosus<\/jats:italic>\n                      supernatant to cell culture medium was 1:1 and the co-culture time was 16\u00a0h, the inhibitory effect on SCC15 was the most obvious; Furthermore, the supernatant of\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      upregulated the autophagy activity of SCC15, thus significantly inhibiting its proliferation, migration and invasion ability. Compared with control groups, the cell cycle showed G1 arrest, S and G2\/M phases decreased, and the percentage of apoptotic cells relatively increased (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>S. anginosus<\/jats:italic>\n                      reduced the proliferation, migration and invasion of SCC15 cells and promoted cell apoptosis; Moreover, autophagy may be one of the mechanisms in this process.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-021-01505-3","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T15:02:31Z","timestamp":1616252551000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of Streptococcus anginosus on biological response of tongue squamous cell carcinoma cells"],"prefix":"10.1186","volume":"21","author":[{"given":"Yuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-850X","authenticated-orcid":false,"given":"DeQin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"issue":"1","key":"1505_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.gde.2008.01.003","volume":"18","author":"P Allavena","year":"2008","unstructured":"Allavena P, Garlanda C, Borrello MG, Sica A, Mantovani A. 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