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All specimens were positioned in a custom made artificial oral cavity and perfused with artificial saliva (0.5\u00a0ml\/min). Reflux was simulated 11 times a day during 12\u00a0h by adding HCl (pH 3.0) for 30\u00a0s (flow rate 2\u00a0ml\/min). During the remaining 12\u00a0h (overnight), specimens were stored in artificial saliva and brushed twice a day (morning and evening) with a toothbrush and toothpaste slurry (15 brushing strokes). While specimens in the control group (G1) did not receive any further treatment, specimens in G2\u20135 were coated with different fluoride gels [Elmex Gel\u00e9e (G2); Paro Amin Fluor Gel\u00e9e (G3); Paro Fluor Gel\u00e9e Natriumfluorid (G4); Sensodyne ProSchmelz Fluorid Gel\u00e9e (G5)] in the evening for 30\u00a0s. After 20\u00a0days, surface profiles were recorded again and enamel loss was determined by comparing them with the baseline profiles. The results were statistically analysed using one-way analysis of variance (ANOVA) followed by Tukey`s HSD post-hoc test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall highest mean wear of enamel (9.88\u2009\u00b1\u20091.73\u00a0\u00b5m) was observed in the control group (G1), where no fluoride gel was applied. It was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to all other groups. G2 (5.03\u2009\u00b1\u20091.43\u00a0\u00b5m), G3 (5.47\u2009\u00b1\u20090.63\u00a0\u00b5m,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.918) and G4 (5.14\u2009\u00b1\u20090.82\u00a0\u00b5m,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.999) showed the overall best protection from hydrochloric acid induced erosion. Enamel wear in G5 (6.64\u2009\u00b1\u20090.86\u00a0\u00b5m) was significantly higher compared to G2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028) and G4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After 20\u00a0days of daily application, all investigated fluoride gels are able to significantly reduce gastroesophageal reflux induced loss of enamel.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-021-01548-6","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T10:03:04Z","timestamp":1617962584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Potential of different fluoride gels to prevent erosive tooth wear caused by gastroesophageal reflux"],"prefix":"10.1186","volume":"21","author":[{"given":"Philipp","family":"K\u00f6rner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Georgis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Wiedemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Attin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian J.","family":"Wegehaupt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"1548_CR1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s40496-015-0064-9","volume":"2","author":"MD Lagerweij","year":"2015","unstructured":"Lagerweij MD, van Loveren C. 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