{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:08:35Z","timestamp":1776780515157,"version":"3.51.2"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The aim of the present investigation was to evaluate the literature recurrence of peripheral giant cell granuloma and pyogenic granuloma associated with dental implants. It\u2019s important to know the characteristics present in these lesions and possible effects on the prognosis of dental implants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>An electronic search without time restrictions was done in the databases: PubMed\/Medline. With the keywords \"Granuloma\" OR \"Granuloma, Giant Cell\" OR \"peripheral giant cell\" OR \"Granuloma, Pyogenic\u201d AND \"Dental implants\" OR \"Oral implants\u201d.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After applying the inclusion and exclusion criteria, a total of 20 articles were included, which reported 32 lesions (10 pyogenic granulomas, 21 peripheral giant cell granulomas and one peripheral giant cell granuloma combined with peripheral ossifying fibroma, all associated with implants). According to our review, these lesions are more frequent in males and in the posterior region of the mandible. Both excision and curettage of the lesion, compared to only excision, presented similar recurrences (40%). Explantation of the implant was performed in 41% of cases without additional recurrences. The results are not statistically significant when comparing one lesion to the other in terms of explantation (<jats:italic>p<\/jats:italic>\u2009=\u20090.97), recurrence (<jats:italic>p<\/jats:italic>\u2009=\u20090.57) or bone loss (<jats:italic>p<\/jats:italic>\u2009=\u20090.67).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The main therapeutic approach is tissue excision. The lesions show a high recurrence rate (34.4%), which often requires explantation of the associated implant. This recurrence rate is not affected by curettage after excision.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-021-01566-4","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T12:07:25Z","timestamp":1619179645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An analysis of the prevalence of peripheral giant cell granuloma and pyogenic granuloma in relation to a dental implant"],"prefix":"10.1186","volume":"21","author":[{"given":"Nieves","family":"Rom\u00e1n-Quesada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Gonz\u00e1lez-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keila","family":"Izquierdo-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Jan\u00e9-Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mar\u00ed-Roig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Estrugo-Devesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-4412","authenticated-orcid":false,"given":"Jos\u00e9","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"1566_CR1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.11607\/jomi.2869","volume":"29","author":"HJ Han","year":"2014","unstructured":"Han HJ, Kim S, Han DH. Multifactorial evaluation of implant failure: a 19-year retrospective study. Int J Oral Maxillofac Implants. 2014;29:303\u201310.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"1566_CR2","doi-asserted-by":"publisher","first-page":"e12342","DOI":"10.1111\/jicd.12342","volume":"9","author":"F Atarbashi-Moghadam","year":"2018","unstructured":"Atarbashi-Moghadam F, Atarbashi-Moghadam S, Namdari M, Shahrabi-Farahani S. Reactive oral lesions associated with dental implants. A systematic review. J Investig Clin Dent. 2018;9:e12342.","journal-title":"J Investig Clin Dent"},{"key":"1566_CR3","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1902\/jop.2016.150482","volume":"87","author":"M Halperin-Sternfeld","year":"2016","unstructured":"Halperin-Sternfeld M, Sabo E, Akrish S. The pathogenesis of implant-related reactive lesions: a clinical, histologic and polarized light microscopy study. J Periodontol. 2016;87:502\u201310.","journal-title":"J Periodontol"},{"key":"1566_CR4","doi-asserted-by":"publisher","first-page":"e196","DOI":"10.1097\/SCS.0000000000004281","volume":"29","author":"A Scarano","year":"2018","unstructured":"Scarano A, Lorusso C, Mortellaro C, Limongelli L, Tempesta A, Favia G. Peripheral giant cell granuloma associated with dental implants. J Craniofac Surg. 2018;29:e196\u20139.","journal-title":"J Craniofac Surg"},{"key":"1566_CR5","first-page":"4","volume":"34","author":"SJ Froum","year":"2013","unstructured":"Froum SJ. The team approach to managing dental implant complications: the periodontist\u2019s point of view. Compend Contin Educ Dent. 2013;34:4\u20139.","journal-title":"Compend Contin Educ Dent"},{"key":"1566_CR6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1600-051X.2008.01274.x","volume":"35","author":"UN Zitzmann","year":"2018","unstructured":"Zitzmann UN, Berglundh T. Definition and prevalence of peri-implant diseases. J Clin Periodontol. 2018;35:286\u201391.","journal-title":"J Clin Periodontol"},{"key":"1566_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdent.2017.04.011","volume":"62","author":"CT Lee","year":"2017","unstructured":"Lee CT, Huang YW, Zhu L, Weltman R. Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis. J Dent. 2017;62:1\u201312.","journal-title":"J Dent"},{"key":"1566_CR8","doi-asserted-by":"publisher","first-page":"S158","DOI":"10.1111\/jcpe.12334","volume":"42","author":"J Derks","year":"2015","unstructured":"Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015;42:S158\u201371.","journal-title":"J Clin Periodontol"},{"key":"1566_CR9","doi-asserted-by":"publisher","first-page":"839032","DOI":"10.1155\/2015\/839032","volume":"2015","author":"E Jan\u00e9-Salas","year":"2015","unstructured":"Jan\u00e9-Salas E, Albuquerque R, Font-Mu\u00f1oz A, Gonz\u00e1lez-Navarro B, EstrugoDevesa A, L\u00f3pez-L\u00f3pez J. Pyogenic granuloma\/peripheral giant cell granuloma associated with implants. Int J Dent. 2015;2015:839032.","journal-title":"Int J Dent"},{"key":"1566_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/2231-0762.155725","volume":"5","author":"HM Al-Shamiri","year":"2015","unstructured":"Al-Shamiri HM, Alaizari NA, Al-Maweri SA, Tarakji B. Development of pyogenic granuloma and hemangioma after placement of dental implants: a review of literature. J Int Soc Prev Community Dent. 2015;5:77\u201380.","journal-title":"J Int Soc Prev Community Dent"},{"key":"1566_CR11","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1902\/jop.2009.090081","volume":"80","author":"G Hernandez","year":"2009","unstructured":"Hernandez G, Lopez-Pintor RM, Torres J, de Vicente JC. Clinical outcomes of peri-implant peripheral giant cell granuloma: a report of three cases. J Periodontol. 2009;80:1184\u201391.","journal-title":"J Periodontol"},{"key":"1566_CR12","doi-asserted-by":"publisher","first-page":"e447","DOI":"10.4317\/jced.52094","volume":"7","author":"E Anitua","year":"2015","unstructured":"Anitua E, Pinas L. Pyogenic granuloma in relation to dental implants: clinical and histopathological findings. J Clin Exp Dent. 2015;7:e447\u201350.","journal-title":"J Clin Exp Dent"},{"key":"1566_CR13","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jormas.2019.01.010","volume":"120","author":"BR Chrcanovic","year":"2019","unstructured":"Chrcanovic BR, Gomes CC, Gomez RS. Peripheral giant cell granuloma associated with dental implants: a systematic review. J Stomatol Oral Maxillofac Surg. 2019;120:456\u201361.","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"1566_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0278-2391(88)90303-5","volume":"46","author":"BR Smith","year":"1998","unstructured":"Smith BR, Fowler CB, Svane TJ. Primary hyperparathyroidism presenting as a \u201cperipheral\u201d giant cell granuloma. J Oral Maxillofac Surg. 1998;46:65\u20139.","journal-title":"J Oral Maxillofac Surg"},{"key":"1566_CR15","doi-asserted-by":"publisher","first-page":"266","DOI":"10.4067\/S0718-381X2019000300266","volume":"13","author":"A Alarc\u00f3n-Arratia","year":"2019","unstructured":"Alarc\u00f3n-Arratia A, Mu\u00f1oz-Repetto M, Schnettler K, Ulloa-Marin C. Peripheral giant cell granuloma and hyperparathyroidism. Case report. Int J Odontostomat. 2019;13:266\u201370.","journal-title":"Int J Odontostomat"},{"key":"1566_CR16","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.joms.2012.11.013","volume":"71","author":"JJ Wilson","year":"2013","unstructured":"Wilson JJ, Schwartz HC, Tehrany GM. Brown tumor of the posterior maxilla as initial manifestation of primary hyperparathyroidism: case report. J Oral Maxillofac Surg. 2013;71:886\u201390.","journal-title":"J Oral Maxillofac Surg"},{"key":"1566_CR17","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.prosdent.2019.02.014","volume":"122","author":"AS Bidra","year":"2019","unstructured":"Bidra AS, Persenaire MJ, Natarajan E. Management of peripheral giant cell granuloma around complete-arch fixed implant-supported prosthesis: a case series. J Prosthet Dent. 2019;122:181\u20138.","journal-title":"J Prosthet Dent"},{"key":"1566_CR18","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.","journal-title":"PLoS Med"},{"key":"1566_CR19","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1563\/AAID-JOI-D-11-00143","volume":"38","author":"MA Pe\u00f1arrocha-Diago","year":"2012","unstructured":"Pe\u00f1arrocha-Diago MA, Cervera-Ballester J, Maestre-Ferr\u00edn L, Pe\u00f1arrocha-Oltra D. Peripheral Giant cell granuloma associated with dental implants: clinical case and literature review. J Oral Implantol. 2012;38:527\u201332.","journal-title":"J Oral Implantol"},{"key":"1566_CR20","first-page":"697673","volume":"2015","author":"AL Brown","year":"2015","unstructured":"Brown AL, Camargo de Moraes P, Sperandio M, Borges Soares A, Ara\u00fajo VC, Passador-Santos F. Peripheral giant cell granuloma associated with a dental implant: a case report and review of the literature. Case Rep Dent. 2015;2015:697673.","journal-title":"Case Rep Dent"},{"key":"1566_CR21","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.tripleo.2006.08.003","volume":"103","author":"M Cloutier","year":"2007","unstructured":"Cloutier M, Charles M, Carmichael RP, S\u00e1ndor GK. An analysis of peripheral giant cell granuloma associated with dental implant treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:618\u201322.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"1566_CR22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/1752-1947-8-192","volume":"8","author":"YH Kang","year":"2014","unstructured":"Kang YH, Byun JH, Choi MJ, Lee JS, Jang JH, Kim YI, Park BW. Co-development of pyogenic granuloma and capillary hemangioma on the alveolar ridge associated with a dental implant: a case report. J Med Case Rep. 2014;8:192.","journal-title":"J Med Case Rep"},{"key":"1566_CR23","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1902\/jop.2003.74.9.1381","volume":"74","author":"A Hirshberg","year":"2003","unstructured":"Hirshberg A, Kozlovsky A, Schwartz-Arad D, Mardinger O, Kaplan I. Peripheral giant cell granuloma associated with dental implants. J Periodontol. 2003;74:1381\u20134.","journal-title":"J Periodontol"},{"key":"1566_CR24","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ijom.2009.11.007","volume":"39","author":"DG Olmedo","year":"2010","unstructured":"Olmedo DG, Paparella ML, Brandizzi D, Cabrini RL. Reactive lesions of peri-implant mucosa associated with titanium dental implants: a report of 2 cases. Int J Oral Maxillofac Surg. 2010;39:503\u20137.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1566_CR25","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1016\/j.joms.2009.06.015","volume":"68","author":"I Dojcinovic","year":"2010","unstructured":"Dojcinovic I, Richter M, Lombardi T. Occurrence of a pyogenic granuloma in relation to a dental implant. J Oral Maxillofac Surg. 2010;68:1874\u20136.","journal-title":"J Oral Maxillofac Surg"},{"key":"1566_CR26","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1563\/AAID-JOI-D-11-00166","volume":"39","author":"OA Et\u00f6z","year":"2013","unstructured":"Et\u00f6z OA, Soylu E, Kili\u00e7 K, G\u00fcnhan \u00d6, Akcay H, Alkan A. A reactive lesion (pyogenic granuloma) associated with dental implant: a case report. J Oral Implantol. 2013;39:733\u20136.","journal-title":"J Oral Implantol"},{"key":"1566_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1752-1947-9-14","volume":"9","author":"EI Ogbureke","year":"2015","unstructured":"Ogbureke EI, Vigneswaran N, Seals M, Frey G, Johnson CD, Ogbureke KU. A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. J Med Case Rep. 2015;9:14.","journal-title":"J Med Case Rep"},{"key":"1566_CR28","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1563\/AAID-JOI-D-13-00251","volume":"41","author":"A Kaya","year":"2015","unstructured":"Kaya A, Ugurlu F, Basel B, Sener CB. Oral pyogenic granuloma associated with a dental implant treated with an Er:YAG laser: a case report. J Oral Implantol. 2015;41:720\u20133.","journal-title":"J Oral Implantol"},{"key":"1566_CR29","first-page":"976756","volume":"2015","author":"A Pacifici","year":"2015","unstructured":"Pacifici A, Carbone D, Marini R, Sfasciotti GL, Pacifici L. Clinical management of a peri-implant giant cell granuloma. Case Rep Dent. 2015;2015:976756.","journal-title":"Case Rep Dent"},{"key":"1566_CR30","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1089\/pho.2016.4089","volume":"34","author":"A Truschnegg","year":"2016","unstructured":"Truschnegg A, Acham S, Kqiku L, Beham A, Jakse N. CO2 laser excision of a pyogenic granuloma associated with dental implants: a case report and review of the literature. Photomed Laser Surg. 2016;34:425\u201331.","journal-title":"Photomed Laser Surg"},{"key":"1566_CR31","doi-asserted-by":"publisher","first-page":"573","DOI":"10.11607\/prd.2387","volume":"36","author":"L Gefrerer","year":"2016","unstructured":"Gefrerer L, Popowski W, Perek JN, Wojtowicz A. Recurrent pyogenic granuloma around dental implants: a rare case report. Int J Periodontics Restorative Dent. 2016;36:573\u201381.","journal-title":"Int J Periodontics Restorative Dent"},{"key":"1566_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1563\/AAID-JOI-D-13-00155","volume":"42","author":"P Galindo-Moreno","year":"2016","unstructured":"Galindo-Moreno P, Hern\u00e1ndez-Cort\u00e9s P, R\u00edos R, S\u00e1nchez-Fern\u00e1ndez E, C\u00e1mara M, O\u2019Valle F. Immunophenotype of dental implant-associated peripheral giant cell reparative granuloma in a representative case report. J Oral Implantol. 2016;42:55\u201360.","journal-title":"J Oral Implantol"},{"key":"1566_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1186\/s12903-019-0983-2","volume":"19","author":"RCP Baesso","year":"2019","unstructured":"Baesso RCP, de Lima Jacy Monteiro Barki MC, de Souza Azevedo R, da Costa Fontes KBF, Pereira DL, Tucci R, Pires FR, Picciani BLS. Peripheral giant cell granuloma associated with a dental implant. BMC Oral Health. 2019;19:283.","journal-title":"BMC Oral Health"},{"key":"1566_CR34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/cap.10056","volume":"9","author":"L Mordini","year":"2019","unstructured":"Mordini L. Esthetic management of peripheral giant cell granuloma affecting a dental implant in the esthetic zone. Clin Adv Periodontics. 2019;9:77\u201382.","journal-title":"Clin Adv Periodontics"},{"key":"1566_CR35","first-page":"529","volume":"57","author":"A Scarano","year":"2008","unstructured":"Scarano A, Iezzi G, Artese E, Cimorelli E, Piattelli A. Peripheral giant cell granuloma associated with a dental implant. A case report. Miner Stomatol. 2008;57:529\u201334.","journal-title":"Miner Stomatol"},{"key":"1566_CR36","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/jcpe.12348","volume":"42","author":"JP Woelber","year":"2015","unstructured":"Woelber JP, Bienas H, Fabry G, Silbernagel W, Giesler M, Tennert C, Stampf S, Ratka-Kr\u00fcger P, Hellwig E. Oral hygiene-related self-efficacy as a predictor of oral hygiene behaviour: a prospective cohort study. J Clin Periodontol. 2015;42:142\u20139.","journal-title":"J Clin Periodontol"},{"key":"1566_CR37","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.11607\/jomi.4074","volume":"30","author":"M Burbano","year":"2015","unstructured":"Burbano M, Wilson TG Jr, Valderrama P, Blansett J, Wadhwani CP, Choudhary PK, Rodriguez LC, Rodrigues DC. Characterization of cement particles found in peri-implantitis-affected human biopsy specimens. Int J Oral Maxillofac Implants. 2015;30:1168\u201373.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"1566_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/01.ID.0000041425.36813.A9","volume":"12","author":"D Olmedo","year":"2003","unstructured":"Olmedo D, Fern\u00e1ndez MM, Guglielmotti MB, Cabrini RL. Macrophages related to dental implant failure. Implant Dent. 2003;12:75\u201380.","journal-title":"Implant Dent"},{"key":"1566_CR39","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.3390\/ma6115258","volume":"6","author":"DC Rodrigues","year":"2013","unstructured":"Rodrigues DC, Valderrama P, Wilson TG, Palmer K, Thomas A, Sridhar S, Adapalli A, Burbano M, Wadhwani C. Titanium corrosion mechanisms in the oral environment: a retrieval study. Materials. 2013;6:5258\u201374.","journal-title":"Materials"},{"key":"1566_CR40","first-page":"e739","volume":"24","author":"TM Morais","year":"2019","unstructured":"Morais TM, Soares CD, Aguirre Urizar JM, Alberdi-Navarro J, Almeida OP, Pires FR. Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions. Med Oral Patol Oral Cir Bucal. 2019;24:e739\u201374.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"1566_CR41","first-page":"1153","volume":"24","author":"FO \u00d6zden","year":"2009","unstructured":"\u00d6zden FO, Ozden B, Kurt M, G\u00fcnd\u00fcz K, G\u00fcnhan O. Peripheral giant cell granuloma associated with dental implants: a rare case report. Int J Oral Maxillofac Implants. 2009;24:1153\u20136.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"1566_CR42","first-page":"295","volume":"19","author":"M Bischof","year":"2004","unstructured":"Bischof M, Nedir R, Lombardi T. Peripheral giant cell granuloma associated with a dental implant. Int J Oral Maxillofac Implants. 2004;19:295\u20139.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"1566_CR43","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2334\/josnusd.40.57","volume":"40","author":"M G\u00fcnhan","year":"1998","unstructured":"G\u00fcnhan M, G\u00fcnhan O, Celasun B, Mutlu M, Bostanci H. Estrogen and progesterone receptors in the peripheral giant cell granulomas of the oral cavity. J Oral Sci. 1998;40:57\u201360.","journal-title":"J Oral Sci"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-021-01566-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-021-01566-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-021-01566-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T12:08:27Z","timestamp":1619179707000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-021-01566-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,23]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1566"],"URL":"https:\/\/doi.org\/10.1186\/s12903-021-01566-4","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,23]]},"assertion":[{"value":"8 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests<b>.<\/b>","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"204"}}