{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:00:32Z","timestamp":1781737232614,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Treating periodontitis through non-surgical periodontal therapy (NSPT) may improve glycemic control in type-2 Diabetes Mellitus (T2DM) patients. However, the evidence to maintain this improvement beyond four months is insufficient. Hence, this trial was conducted to assess clinical efficacy of NSPT on glycemic control in T2DM patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This three-arm randomized controlled trial recruited 150 known T2DM participants (35\u201365\u00a0years), suffering from moderate to severe periodontitis, having HbA1c level\u2009\u2265\u20096.5% at baseline. Participants were followed up at 3 and 6\u00a0months. Intervention for test group-1 included scaling and root planing (SRP) with metronidazole (MET) and oral hygiene instructions (OHI). Test group-2 was intervened with SRP\u2009+\u2009OHI and control group with OHI only. Stata v. 14 was used to observe inter and intragroup mean changes in glycemic [glycated hemoglobin (HbA1c), fasting blood glucose (FBG)] and periodontal variables [bleeding on probing (BOP), periodontal pocket depth (PPD), clinical attachment loss (CAL)] using ANOVA and RMANOVA. Proportion of change in outcome variable (HbA1c) was assessed between treatment groups using chi-square test. Change was considered significant at <jats:italic>p<\/jats:italic>-value\u2009\u2264\u20090.05.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A significant reduction was observed in BOP, PPD, CAL, HbA1c and FBG over time [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05]. Significant reductions were observed in same variables in both test groups in comparison to control arm [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05]. No change between the two test groups was observed [<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Scaling and root planing improves glycemic control of T2DM patients independently of the use of MET. Therefore, SRP after every 6\u00a0months may be suggested and included as a part of overall diabetes management for patients suffering from T2DM.<\/jats:p>\n                <jats:p><jats:bold>Clinical trial registration<\/jats:bold> NCT 03,343,366 [Date of Registration: 17\/11\/2017]<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-021-01620-1","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T08:03:47Z","timestamp":1620806627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Ambrina","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Akhtar Hussain","family":"Bokhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeba","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhtar Ali","family":"Baloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Zaheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"1620_CR1","first-page":"107","volume":"7","author":"NGM Chavarrya","year":"2009","unstructured":"Chavarrya NGM, Vettorec MV, Sansonea C, Sheihamd A. 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