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The following clinical parameters were recorded at baseline and 6\u00a0months after surgery: pocket depth (PD), gingival recession (GR) and clinical attachment level (CAL). After debridement the intrabony defects were filled with A-PRF+ in the test group, respectively with EMD in the control group, and fixed with sutures to ensure wound closure and stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both treatment methods resulted in statistically significant PD reductions, respectively CAL gains six months post-operatively. No statistically significant differences were found between the two groups as the mean CAL gain was 2.33\u2009\u00b1\u20091.58\u00a0mm in the A-PRF+ group, respectively 2.60\u2009\u00b1\u20091.18\u00a0mm in the EMD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within the limits of this study the new-generation platelet-rich fibrin seems to be as clinically effective as EMD during surgical treatment of intrabony defects. Treatment with A-PRF+ or EMD resulted in reliable clinical outcomes. The use of A-PRF+ as a human autologous product can give a positive impact on periodontal healing.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Clinical Relevance<\/jats:italic>\n                      A-PRF+ may be suitable for the treatment of intrabony periodontal defects.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration number (TRN)<\/jats:italic>\n                      NCT04404374 (ClinicalTrials.gov ID).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-021-01925-1","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T06:03:16Z","timestamp":1636956196000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of a new-generation platelet-rich fibrin in the treatment of periodontal intrabony defects: a randomized clinical trial"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-2916","authenticated-orcid":false,"given":"Bor\u00f3ka Kl\u00e1ra","family":"Csif\u00f3-Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleon\u00f3ra","family":"S\u00f3lyom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Lili","family":"Bogn\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"Nevelits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"D\u0151ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"issue":"1","key":"1925_CR1","doi-asserted-by":"publisher","first-page":"CD009376","DOI":"10.1002\/14651858.CD009376.pub2","volume":"1","author":"C Manresa","year":"2018","unstructured":"Manresa C, Sanz-Miralles EC, Twigg J, Bravo M. 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All the included patients signed an informed consent which was previously approved by an institutional ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"580"}}