{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:01:25Z","timestamp":1776736885193,"version":"3.51.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hypha essential genes (<jats:italic>HEGs<\/jats:italic>) of <jats:italic>Candida Albicans<\/jats:italic> have been emerging into scholar\u2019s attention, little known about their functions in oral lichen planus (OLP) with an uncovered etiology. This research aimed to observe necessary genes in biphasic <jats:italic>C. albicans<\/jats:italic> from OLP and study their relevance in pathogenesis, so as to evaluate possible roles of morphologic switching in etiology of OLP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Samples were collected from OLP lesions of patients, mycelia were cultured and total RNA was extracted then subjected to reverse transcription-PCR and real-time PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>HWP1<\/jats:italic> and <jats:italic>HGC1<\/jats:italic> were significantly expressed in hyphae phase and weakly detected in yeast phase, while there was no significant difference of <jats:italic>EFG1, ALS3, and ECE1<\/jats:italic> between in yeast and mycelia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:italic>HGC1<\/jats:italic> and <jats:italic>HWP1<\/jats:italic> were confirmed to be hypha essential genes, with HGC1 for hypha morphogenesis and <jats:italic>HWP1<\/jats:italic> for adhesion invasion in pathogenesis of <jats:italic>C. albicans<\/jats:italic> in OLP. <jats:italic>ALS3, ECE1<\/jats:italic> and <jats:italic>EFG1<\/jats:italic> played minor roles in hyphae maintenance and adhesion for hyphae. These might be deemed as hints for the etiology of OLP and indicate <jats:italic>HGC1<\/jats:italic> and<jats:italic> HWP1 <\/jats:italic>to be a priority of potential drug target.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-021-01975-5","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T10:03:02Z","timestamp":1638352982000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypha essential genes in Candida albicans pathogenesis of oral lichen planus: an in-vitro study"],"prefix":"10.1186","volume":"21","author":[{"given":"Hong","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"issue":"4","key":"1975_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3109\/10520295.2015.1127425","volume":"91","author":"S Arora","year":"2016","unstructured":"Arora S, Verma M, Gupta SR, Urs AB, Dhakad MS, Kaur R. 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