{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:58:13Z","timestamp":1791568693633,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Deanship of Scientific Research (DSR) at King Abdulaziz University","award":["G-17-165-1441"],"award-info":[{"award-number":["G-17-165-1441"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Celiac disease (CD) is an immune-mediated enteropathy. CD may also involve complications with the oral cavity, which can result in various dental and oral pathologies. There are currently a limited number of studies on the oral manifestation of CD. This study aims to compare the oral manifestations of children with CD against healthy controls in Saudi Arabia.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>This study includes 208 children aged 6\u201314\u00a0years, distributed equally into CD patients and healthy controls. A parent completed and validated the interview questionnaire, which included the child's personal information and medical history. A dental examination was undertaken to measure possible recurrent aphthous stomatitis (RAS), dental enamel defects (DEDs), dental caries experience, and dental malocclusion. Data were analyzed using descriptive statistics and bivariate and multivariate analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Two hundred and eight participants were included (104 CD patients and 104 controls). The mean age for CD patients was 10.67\u2009\u00b1\u20092.39\u00a0years and 10.69\u2009\u00b1\u20092.36 for the healthy controls. CD children had more RAS than controls (42.3% vs. 15.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) (OR\u2009=\u20094.03, 95% CI\u2009=\u20092.09\u20137.81) and more DEDs than healthy controls (70.2% vs. 34.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) (OR\u2009=\u20094.45, 95% CI\u2009=\u20092.48\u20137.97). No significant difference was found in the frequency of malocclusion between cases and controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Saudi Arabian children with CD had a greater number of clinical findings of RAS and DEDs than healthy controls. Pediatric dentists should consider the possibility of CD in child patients presenting with RAS or DEDs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-021-01976-4","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T08:03:59Z","timestamp":1640765039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Oral and dental manifestations of celiac disease in children: a case\u2013control study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-9358","authenticated-orcid":false,"given":"Farah A.","family":"Alsadat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-2675","authenticated-orcid":false,"given":"Najlaa M.","family":"Alamoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-758X","authenticated-orcid":false,"given":"Azza A.","family":"El-Housseiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-5735","authenticated-orcid":false,"given":"Osama M.","family":"Felemban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-2502","authenticated-orcid":false,"given":"Faisal M.","family":"Dardeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-9907","authenticated-orcid":false,"given":"Omar I.","family":"Saadah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"issue":"1","key":"1976_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"S Husby","year":"2012","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 IR, Mearin ML, Phillips A, Shamir R, et al. 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Approval to execute the study was obtained from the Research Ethics Committee at King Abdulaziz University (KAU) (Number 078-09-17). Also, parents had to sign a parental consent form for the participation (including photos) of their child.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"669"}}