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After diversity testing, the differential flora were analyzed. The sequencing results were compared with GenBank database to determine the type of differential flora using species composition analysis, hierarchical cluster analysis, principal co-ordinate analysis, and species difference analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were significant between-group differences with respect to <jats:italic>Gemella<\/jats:italic>, <jats:italic>Selenomonas spp<\/jats:italic>, <jats:italic>Lactobacillales_unclassified, Bacteria-unclassified<\/jats:italic> and <jats:italic>Abiotrophia<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Compared with DM group, the relative abundance of <jats:italic>Selenomonas spp.<\/jats:italic> in DN group was significantly higher; the area under the receiver operating characteristic curve of <jats:italic>Selenomonas spp.<\/jats:italic> was 0.713 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multi-level biological identification and feature maps indicated that <jats:italic>Selenomonas spp.<\/jats:italic> might be used as a potential biomarker for DN patients. On binary logistic regression analysis, increase of <jats:italic>Selenomonas spp.<\/jats:italic> was related with DN.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We found significant between-group differences in the structural composition of oral flora. The increase in the relative abundance of <jats:italic>Selenomonas spp.<\/jats:italic> may be associated with DN in patients with chronic periodontitis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-021-01985-3","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T16:02:42Z","timestamp":1642348962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Difference in oral microbial composition between chronic periodontitis patients with and without diabetic nephropathy"],"prefix":"10.1186","volume":"22","author":[{"given":"Dongxue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,16]]},"reference":[{"key":"1985_CR1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1128\/CMR.13.4.547","volume":"13","author":"X Li","year":"2000","unstructured":"Li X, Kolltveit KM, Tronstad L, Olsen I. 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