{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:30:26Z","timestamp":1791243026494,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical effect of concentrated growth factors (CGF) combined with deproteinized bovine bone mineral (DBBM) on Alveolar ridge preservation during implantology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 38 patients were selected and randomly divided into 2 groups, with 19 cases in each group. The extraction sockets were filled with DBBM with or without CGF. Visual analogue scale (VAS) pain score was recorded within1 week and Landry wound healing index (LWHI) was recorded at 1, 2 and 3 weeks after operation. CBCT was taken preoperatively and 3 and 6 months postoperatively to measure and compare the changes of vertical height, width and gray value of alveolar bone at extraction site. The changes of alveolar bone contour were observed clinically and compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The VAS score of CGF group was lower than control group on the 1st and 3rd day after operation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The LWHI of CGF group was higher than control group 1 week after operation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The absorption of the labial and palatal plates height and the width in the CGF group was significantly less than the control group at 3 months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The gray value of alveolar bone in CGF group was significantly higher than control group at 3\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). There was no significant difference in new bone contour between the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). 94.7% cases in CGF group did not undergo bone grafting, which was significantly higher than control group (78.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of CGF combined with DBBM can help to reduce postoperative pain at the early stage of healing, form sufficient keratinized gingival tissue, effectively maintain the height and width of alveolar bone in the three-dimensional direction and provide good conditions for implant repair in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-022-02091-8","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T09:04:43Z","timestamp":1646298283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth"],"prefix":"10.1186","volume":"22","author":[{"given":"Dilinuer","family":"Keranmu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nijiati","family":"Nuermuhanmode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailimaierdan","family":"Ainiwaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Guli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilidaer","family":"Taxifulati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"issue":"9 Suppl","key":"2091_CR1","doi-asserted-by":"publisher","first-page":"187S","DOI":"10.1177\/0022034515592869","volume":"94","author":"V Chappuis","year":"2015","unstructured":"Chappuis V, Engel O, et al. 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The protocol of this study was consistent with the ethical guidelines of the Declaration of Helsinki and was approved by the Ethics Committee of the First Affiliated Hospital of Xinjiang Medical University (Ethics approval No.: 210723\u201308). All patients voluntarily participated in the study and signed informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of her clinical details and clinical images. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}