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Lactoferrin is a crucial local immunity protein in the oral cavity with important antimicrobial activity. The aim of this study was to prospectively investigate salivary lactoferrin secretion levels and <jats:italic>Candida<\/jats:italic> colonization in oral lichen planus patients treated with fluocinolone acetonide 0.1% in orabase.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Saliva samples were collected from 15 oral lichen planus subjects who had never received topical steroid treatment prior to this study and 15 healthy volunteers to determine their salivary lactoferrin levels using an enzyme-linked immunosorbent assay and to investigate the presence of oral <jats:italic>Candida<\/jats:italic> species at baseline and 3\u00a0months after treatment with fluocinolone acetonide 0.1% in orabase. Statistical analysis was performed to compare lactoferrin secretion and <jats:italic>Candida<\/jats:italic> colonization levels between the groups using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test for independent data or the Wilcoxon Signed-Rank test for paired data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The salivary lactoferrin secretion level was not significantly different between the control group and oral lichen planus patients or between before and after treatment with fluocinolone acetonide 0.1% in orabase (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). <jats:italic>Candida<\/jats:italic> was detected in 11 (73.33%) healthy volunteers, 8 (53.33%) oral lichen planus patients before treatment, and 9 (60%) oral lichen planus patients after treatment with fluocinolone acetonide 0.1% in orabase. There was no significant difference in <jats:italic>Candida<\/jats:italic> counts between the groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study indicates that using fluocinolone acetonide 0.1% in orabase to treat oral lichen planus for 3\u00a0months did not affect salivary lactoferrin protein secretion or <jats:italic>Candida<\/jats:italic> carriage.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>\u00a0The trial was registered at the Thai Clinical Trials Registry (TCTR identifier: TCTR20200723002).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-022-02096-3","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T13:38:28Z","timestamp":1646401108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of fluocinolone acetonide (0.1%) treatment in oral lichen planus patients on salivary lactoferrin levels and Candida colonization: a prospective study"],"prefix":"10.1186","volume":"22","author":[{"given":"Nuttapong","family":"Saengprasittichok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeerus","family":"Sucharitakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oranart","family":"Matangkasombut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanwit","family":"Prapinjumrune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"issue":"1","key":"2096_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","volume":"100","author":"G Lodi","year":"2005","unstructured":"Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. 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The study protocol was explained to the participants. Written informed consent was obtained from the subjects before participating in this study. The privacy rights of the human subjects were observed. All methods were performed in accordance with the principles embodied in the Declaration of Helsinki and in accordance with local statutory requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}