{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:39:35Z","timestamp":1792787975392,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]},{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]},{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]},{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]},{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]},{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]},{"name":"Zhongshan Scientific Research Foundation","award":["2020B1079"],"award-info":[{"award-number":["2020B1079"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was to evaluate the predictors of xerostomia and Grade 3 xerostomia in locoregionally advanced nasopharyngeal carcinoma (NPC) patients receiving radical radiotherapy and establish prediction models for xerostomia and Grade 3 xerostomia based on the predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Totally, 365 patients with locoregionally advanced NPC who underwent radical radiotherapy were randomly divided into the training set (n\u2009=\u2009255) and the testing set (n\u2009=\u2009110) at a ratio of 7:3. All variables were included in the least absolute shrinkage and selection operator regression to screen out the potential predictors for xerostomia as well as the Grade 3 xerostomia in locoregionally advanced NPC patients receiving radical radiotherapy. The random forest (RF), a decision tree classifier (DTC), and extreme-gradient boosting (XGB) models were constructed. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), area under the curve (AUC) and accuracy were analyzed to evaluate the predictive performance of the models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the RF model for predicting xerostomia, the sensitivity was 1.000 (95%CI 1.000\u20131.000), the PPV was 0.990 (95%CI 0.975\u20131.000), the NPV was 1.000 (95%CI 1.000\u20131.000), the AUC was 0.999 (95%CI 0.997\u20131.000) and the accuracy was 0.992 (95%CI 0.981\u20131.000) in the training set. The sensitivity was 0.933 (95%CI 0.880\u20130.985), the PPV was 0.933 (95%CI 0.880\u20130.985), and the AUC was 0.915 (95%CI 0.860\u20130.970) in the testing set. Hypertension, age, total radiotherapy dose, dose at 50% of the left parotid volume, mean dose to right parotid gland, mean dose to oral cavity, and course of induction chemotherapy were important variables associated with the risk of xerostomia in locoregionally advanced NPC patients receiving radical radiotherapy. The AUC of DTC model for predicting xerostomia was 0.769 (95%CI 0.666\u20130.872) in the testing set. The AUC of the XGB model for predicting xerostomia was 0.834 (0.753\u20130.916) in the testing set. The RF model showed the good predictive ability with the AUC of 0.986 (95%CI 0.972\u20131.000) in the training set, and 0.766 (95%CI 0.626\u20130.905) in the testing set for identifying patients who at high risk of Grade 3 xerostomia in those with high risk of xerostomia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An RF model for predicting xerostomia in locoregionally advanced NPC patients receiving radical radiotherapy and an RF model for predicting Grade 3 xerostomia in those with high risk of xerostomia showed good predictive ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-022-02269-0","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T14:02:41Z","timestamp":1655474561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A prediction model for xerostomia in locoregionally advanced nasopharyngeal carcinoma patients receiving radical radiotherapy"],"prefix":"10.1186","volume":"22","author":[{"given":"Minying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingshuang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"issue":"9476","key":"2269_CR1","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1016\/S0140-6736(05)66698-6","volume":"365","author":"WI Wei","year":"2005","unstructured":"Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005;365(9476):2041\u201354.","journal-title":"Lancet"},{"issue":"6","key":"2269_CR2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424.","journal-title":"CA Cancer J Clin"},{"issue":"10192","key":"2269_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","volume":"394","author":"YP Chen","year":"2019","unstructured":"Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64\u201380.","journal-title":"Lancet"},{"issue":"1","key":"2269_CR4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40880-017-0257-9","volume":"36","author":"KR Wei","year":"2017","unstructured":"Wei KR, Zheng RS, Zhang SW, Liang ZH, Li ZM, Chen WQ. Nasopharyngeal carcinoma incidence and mortality in China, 2013. Chin J Cancer. 2017;36(1):90.","journal-title":"Chin J Cancer"},{"issue":"1","key":"2269_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13046-018-0997-7","volume":"38","author":"H Peng","year":"2019","unstructured":"Peng H, Zhang J, Zhang PP, Chen L, Tang LL, Yang XJ, et al. ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2019;38(1):11.","journal-title":"J Exp Clin Cancer Res"},{"issue":"21","key":"2269_CR6","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1002\/cncr.30198","volume":"122","author":"JJ Pan","year":"2016","unstructured":"Pan JJ, Ng WT, Zong JF, Lee SW, Choi HC, Chan LL, et al. Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC\/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy. Cancer. 2016;122(21):3307\u201315.","journal-title":"Cancer"},{"issue":"2","key":"2269_CR7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.oraloncology.2012.08.013","volume":"49","author":"CN Cao","year":"2013","unstructured":"Cao CN, Luo JW, Gao L, Yi JL, Huang XD, Wang K, et al. Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for T4 nasopharyngeal carcinoma. Oral Oncol. 2013;49(2):175\u201381.","journal-title":"Oral Oncol"},{"key":"2269_CR8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.oraloncology.2015.11.015","volume":"53","author":"J Setton","year":"2016","unstructured":"Setton J, Han J, Kannarunimit D, Wuu YR, Rosenberg SA, DeSelm C, et al. Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma. Oral Oncol. 2016;53:67\u201373.","journal-title":"Oral Oncol"},{"issue":"1","key":"2269_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.7314\/APJCP.2012.13.1.075","volume":"13","author":"MF Gu","year":"2012","unstructured":"Gu MF, Su Y, Chen XL, He WL, He ZY, Li JJ, et al. Quality of life and radiotherapy complications of Chinese nasopharyngeal carcinoma patients at different 3DCRT. Asian Pac J Cancer Prev. 2012;13(1):75\u20139.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"2","key":"2269_CR10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3857\/roj.2015.33.2.98","volume":"33","author":"CW Wee","year":"2015","unstructured":"Wee CW, Keam B, Heo DS, Sung MW, Won TB, Wu HG. Locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy plus concurrent weekly cisplatin with or without neoadjuvant chemotherapy. Radiat Oncol J. 2015;33(2):98\u2013108.","journal-title":"Radiat Oncol J"},{"issue":"10","key":"2269_CR11","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/hed.23488","volume":"36","author":"ZH Wang","year":"2014","unstructured":"Wang ZH, Yan C, Zhang ZY, Zhang CP, Hu HS, Tu WY, et al. Outcomes and xerostomia after postoperative radiotherapy for oral and oropharyngeal carcinoma. Head Neck. 2014;36(10):1467\u201373.","journal-title":"Head Neck"},{"issue":"2","key":"2269_CR12","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ijrobp.2018.05.060","volume":"102","author":"LJ McDowell","year":"2018","unstructured":"McDowell LJ, Rock K, Xu W, Chan B, Waldron J, Lu L, et al. Long-term late toxicity, quality of life, and emotional distress in patients with nasopharyngeal carcinoma treated with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2018;102(2):340\u201352.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"2269_CR13","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1080\/0284186X.2017.1324209","volume":"56","author":"HS Gabry\u015b","year":"2017","unstructured":"Gabry\u015b HS, Buettner F, Sterzing F, Hauswald H, Bangert M. Parotid gland mean dose as a xerostomia predictor in low-dose domains. Acta Oncol. 2017;56(9):1197\u2013203.","journal-title":"Acta Oncol"},{"issue":"10","key":"2269_CR14","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jfma.2011.08.009","volume":"110","author":"DS Lin","year":"2011","unstructured":"Lin DS, Jen YM, Lee JC, Liu SC, Lin YS. Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy. J Formos Med Assoc. 2011;110(10):655\u201360.","journal-title":"J Formos Med Assoc"},{"issue":"44","key":"2269_CR15","doi-asserted-by":"publisher","first-page":"78096","DOI":"10.18632\/oncotarget.17481","volume":"8","author":"XB Pan","year":"2017","unstructured":"Pan XB, Chen KH, Huang ST, Jiang YM, Ma JL, Liang ZG, Qu S, Li L, Chen L, Zhu XD. Comparison of the efficacy between intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in stage II nasopharyngeal carcinoma. Oncotarget. 2017;8(44):78096\u2013104.","journal-title":"Oncotarget"},{"issue":"2","key":"2269_CR16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.radonc.2008.12.017","volume":"90","author":"JA Langendijk","year":"2009","unstructured":"Langendijk JA, Doornaert P, Rietveld DH, Verdonck-de Leeuw IM, Leemans CR, Slotman BJ. A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol. 2009;90(2):189\u201395.","journal-title":"Radiother Oncol"},{"issue":"2","key":"2269_CR17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4103\/0975-5950.183870","volume":"6","author":"N Gupta","year":"2015","unstructured":"Gupta N, Pal M, Rawat S, et al. Radiation-induced dental caries, prevention and treatment\u2014A systematic review. Natl J Maxillofac Surg. 2015;6(2):160\u20136.","journal-title":"Natl J Maxillofac Surg"},{"issue":"2","key":"2269_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ijrobp.2018.01.097","volume":"101","author":"E Greco","year":"2018","unstructured":"Greco E, Simic T, Ringash J, Tomlinson G, Inamoto Y, Martino R. Dysphagia treatment for patients with head and neck cancer undergoing radiation therapy: a meta-analysis review. Int J Radiat Oncol Biol Phys. 2018;101(2):421\u201344.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"2269_CR19","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.radonc.2013.10.020","volume":"110","author":"X Sun","year":"2014","unstructured":"Sun X, Su S, Chen C, Han F, Zhao C, Xiao W, Deng X, Huang S, Lin C, Lu T. Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2014;110(3):398\u2013403.","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"issue":"14","key":"2269_CR20","doi-asserted-by":"publisher","first-page":"18645","DOI":"10.18632\/aging.203308","volume":"13","author":"K Yang","year":"2021","unstructured":"Yang K, Xie W, Zhang X, Wang Y, Shou A, Wang Q, Tian J, Yang J, Li G. A nomogram for predicting late radiation-induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era. Aging. 2021;13(14):18645\u201357.","journal-title":"Aging"},{"issue":"5","key":"2269_CR21","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","volume":"31","author":"JD Cox","year":"1995","unstructured":"Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31(5):1341\u20136.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"2269_CR22","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/hr.2014.20","volume":"37","author":"K Shimamoto","year":"2014","unstructured":"Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu T, Ito M, et al. The Japanese society of hypertension guidelines for the management of hypertension (JSH 2014). Hypertens Res Off J Jpn Soc Hypertens. 2014;37(4):253\u2013390.","journal-title":"Hypertens Res Off J Jpn Soc Hypertens"},{"issue":"5","key":"2269_CR23","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3390\/nu12051422","volume":"12","author":"M Kuwabara","year":"2020","unstructured":"Kuwabara M, Kanbay M, Niwa K, Ae R, Andres-Hernando A, Roncal-Jimenez CA, Garcia G, S\u00e1nchez-Lozada LG, Rodriguez-Iturbe B, Hisatome I, et al. Hyperosmolarity and increased serum sodium concentration are risks for developing hypertension regardless of salt intake: a five-year cohort study in Japan. Nutrients. 2020;12(5):1422.","journal-title":"Nutrients"},{"key":"2269_CR24","first-page":"30","volume":"12","author":"Q Deng","year":"2013","unstructured":"Deng Q, Liu J, Li Q, Chen K, Liu Z, Shen Y, Niu P, Yang Y, Zou Y, Yang X. Interaction of occupational manganese exposure and alcohol drinking aggravates the increase of liver enzyme concentrations from a cross-sectional study in China. Environ Health Glob Access Sci Source. 2013;12:30.","journal-title":"Environ Health Glob Access Sci Source"},{"issue":"2","key":"2269_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/adj.12608","volume":"63","author":"C Sim","year":"2018","unstructured":"Sim C, Soong YL, Pang E, Lim C, Walker GD, Manton DJ, Reynolds EC, Wee J. Xerostomia, salivary characteristics and gland volumes following intensity-modulated radiotherapy for nasopharyngeal carcinoma: a two-year follow up. Aust Dent J. 2018;63(2):217\u201323.","journal-title":"Aust Dent J"},{"issue":"1","key":"2269_CR26","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.radonc.2011.05.010","volume":"105","author":"I Beetz","year":"2012","unstructured":"Beetz I, Schilstra C, Burlage FR, Koken PW, Doornaert P, Bijl HP, et al. Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: the role of dosimetric and clinical factors. Radiother Oncol. 2012;105(1):86\u201393.","journal-title":"Radiother Oncol"},{"key":"2269_CR27","first-page":"2401743","volume":"2019","author":"F Teng","year":"2019","unstructured":"Teng F, Fan W, Luo Y, Ju Z, Gong H, Ge R, et al. Reducing xerostomia by comprehensive protection of salivary glands in intensity-modulated radiation therapy with helical tomotherapy technique for head-and-neck cancer patients: a prospective observational study. Biomed Res Int. 2019;2019:2401743.","journal-title":"Biomed Res Int"},{"issue":"7","key":"2269_CR28","doi-asserted-by":"publisher","first-page":"e40636","DOI":"10.1371\/journal.pone.0040636","volume":"7","author":"R Stiubea-Cohen","year":"2012","unstructured":"Stiubea-Cohen R, David R, Neumann Y, Krief G, Deutsch O, Zacks B, Aframian DJ, Palmon A. Effect of irradiation on cell transcriptome and proteome of rat submandibular salivary glands. PLoS ONE. 2012;7(7):e40636.","journal-title":"PLoS ONE"},{"key":"2269_CR29","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.radonc.2020.06.016","volume":"150","author":"X Lan","year":"2020","unstructured":"Lan X, Chan JYK, Pu JJ, Qiao W, Pang S, Yang WF, Wong KCW, Kwong DLW, Su YX. Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2020;150:97\u2013103.","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"issue":"43","key":"2269_CR30","doi-asserted-by":"publisher","first-page":"75577","DOI":"10.18632\/oncotarget.17483","volume":"8","author":"P Yang","year":"2017","unstructured":"Yang P, Elhalawani H, Shi Y, Tang Y, Han Y, Zhao Y, et al. A large-scale retrospective study of the overall survival outcome in nasopharyngeal carcinoma with hypertension in Chinese population. Oncotarget. 2017;8(43):75577\u201386.","journal-title":"Oncotarget"},{"issue":"9","key":"2269_CR31","doi-asserted-by":"publisher","first-page":"5217","DOI":"10.1007\/s00784-021-03829-4","volume":"25","author":"M Kawamoto","year":"2021","unstructured":"Kawamoto M, Yamada SI, Gibo T, Kajihara R, Nagashio S, Tanaka H, Yajima J, Takizawa A, Kondo E, Sakai H, et al. Relationship between dry mouth and hypertension. Clin Oral Investig. 2021;25(9):5217\u201325.","journal-title":"Clin Oral Investig"},{"issue":"7","key":"2269_CR32","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.14219\/jada.archive.1995.0277","volume":"126","author":"CF Streckfus","year":"1995","unstructured":"Streckfus CF. Salivary function and hypertension: a review of the literature and a case report. J Am Dent Assoc. 1995;126(7):1012\u20137.","journal-title":"J Am Dent Assoc"},{"issue":"Suppl 3","key":"2269_CR33","first-page":"154","volume":"63","author":"R B\u00f6hm","year":"1985","unstructured":"B\u00f6hm R, van Baak M, van Hooff M, Moy J, Rahn KH. Salivary flow in borderline hypertension. Klin Wochenschr. 1985;63(Suppl 3):154\u20136.","journal-title":"Klin Wochenschr"},{"issue":"16","key":"2269_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/MD.0000000000019583","volume":"99","author":"MLZ Varellis","year":"2020","unstructured":"Varellis MLZ, Gon\u00e7alves MLL, Pavesi VCS, Horliana A, de F\u00e1tima Teixeira da Silva D, Motta LJ, et al. Evaluation of photobiomodulation in salivary production of patients with xerostomy induced by anti-hypertensive drugs: Study protocol clinical trial (SPIRIT compliant). Medicine. 2020;99(16):83.","journal-title":"Medicine"},{"issue":"2","key":"2269_CR35","first-page":"e185","volume":"22","author":"RM L\u00f3pez-Pintor","year":"2017","unstructured":"L\u00f3pez-Pintor RM, L\u00f3pez-Pintor L, Casa\u00f1as E, de Arriba L, Hern\u00e1ndez G. Risk factors associated with xerostomia in haemodialysis patients. Med Oral Patol Oral Cir Bucal. 2017;22(2):e185\u201392.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"1\u20132","key":"2269_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.brainres.2005.06.071","volume":"1055","author":"AC Takakura","year":"2005","unstructured":"Takakura AC, Moreira TS, De Luca LA Jr, Renzi A, Menani JV, Colombari E. Effects of AV3V lesion on pilocarpine-induced pressor response and salivary gland vasodilation. Brain Res. 2005;1055(1\u20132):111\u201321.","journal-title":"Brain Res"},{"issue":"9","key":"2269_CR37","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1634\/theoncologist.2017-0015","volume":"22","author":"P Szturz","year":"2017","unstructured":"Szturz P, Wouters K, Kiyota N, Tahara M, Prabhash K, Noronha V, et al. Weekly low-dose versus three-weekly high-dose cisplatin for concurrent chemoradiation in locoregionally advanced non-nasopharyngeal head and neck cancer: a systematic review and meta-analysis of aggregate data. Oncologist. 2017;22(9):1056\u201366.","journal-title":"Oncologist"},{"issue":"1","key":"2269_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ijrobp.2005.12.003","volume":"65","author":"JL Yi","year":"2006","unstructured":"Yi JL, Gao L, Huang XD, Li SY, Luo JW, Cai WM, et al. Nasopharyngeal carcinoma treated by radical radiotherapy alone: ten-year experience of a single institution. Int J Radiat Oncol Biol Phys. 2006;65(1):161\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"2269_CR39","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ijrobp.2010.03.024","volume":"80","author":"SZ Lai","year":"2011","unstructured":"Lai SZ, Li WF, Chen L, Luo W, Chen YY, Liu LZ, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys. 2011;80(3):661\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"2269_CR40","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1080\/0284186X.2019.1627413","volume":"58","author":"JK Kaae","year":"2019","unstructured":"Kaae JK, Johnsen L, Hansen CR, Kristensen MH, Brink C, Eriksen JG. Relationship between patient and physician-rated xerostomia and dose distribution to the oral cavity and salivary glands for head and neck cancer patients after radiotherapy. Acta Oncol (Stockholm, Sweden). 2019;58(10):1366\u201372.","journal-title":"Acta Oncol (Stockholm, Sweden)"},{"issue":"10","key":"2269_CR41","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1093\/jjco\/hyl098","volume":"36","author":"WS Liu","year":"2006","unstructured":"Liu WS, Lee SP, Lee JK, Su MC, Chen GD, Lee HS, Lee H. Factors influencing the parotid function in nasopharyngeal carcinoma treated with parotid-sparing radiotherapy. Jpn J Clin Oncol. 2006;36(10):626\u201331.","journal-title":"Jpn J Clin Oncol"},{"issue":"1","key":"2269_CR42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/jjco\/hyp113","volume":"40","author":"K Teshima","year":"2010","unstructured":"Teshima K, Murakami R, Tomitaka E, Nomura T, Toya R, Hiraki A, Nakayama H, Hirai T, Shinohara M, Oya N, et al. Radiation-induced parotid gland changes in oral cancer patients: correlation between parotid volume and saliva production. Jpn J Clin Oncol. 2010;40(1):42\u20136.","journal-title":"Jpn J Clin Oncol"},{"issue":"3","key":"2269_CR43","first-page":"492","volume":"53","author":"K Teshima","year":"2012","unstructured":"Teshima K, Murakami R, Yoshida R, Nakayama H, Hiraki A, Hirai T, Nakaguchi Y, Tsujita N, Tomitaka E, Furusawa M, et al. Histopathological changes in parotid and submandibular glands of patients treated with preoperative chemoradiation therapy for oral cancer. J Radiat Res. 2012;53(3):492\u20136.","journal-title":"J Radiat Res"},{"issue":"36","key":"2269_CR44","doi-asserted-by":"publisher","first-page":"e17030","DOI":"10.1097\/MD.0000000000017030","volume":"98","author":"XB Pan","year":"2019","unstructured":"Pan XB, Liu Y, Huang ST, Chen KH, Jiang YM, Zhu XD. Predictors for improvement of xerostomia in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy. Medicine. 2019;98(36):e17030.","journal-title":"Medicine"},{"issue":"1","key":"2269_CR45","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13014-018-1092-0","volume":"13","author":"L Liu","year":"2018","unstructured":"Liu L, Fei Z, Chen M, Zhao L, Su H, Gu D, Lin B, Cai X, Lu L, Gao M, et al. Induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus volumetric modulated arc therapy alone in the treatment of stage II-IVB nasopharyngeal carcinoma patients: a retrospective controlled study. Radiat Oncol (Lond, Engl). 2018;13(1):148.","journal-title":"Radiat Oncol (Lond, Engl)"},{"issue":"1","key":"2269_CR46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/bjc.2013.720","volume":"110","author":"L Zeng","year":"2014","unstructured":"Zeng L, Tian YM, Sun XM, Chen CY, Han F, Xiao WW, Deng XW, Lu TX. Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors. Br J Cancer. 2014;110(1):49\u201354.","journal-title":"Br J Cancer"},{"issue":"10","key":"2269_CR47","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1111\/jog.14963","volume":"47","author":"C Shinohara","year":"2021","unstructured":"Shinohara C, Ito K, Takamatsu K, Ogawa M, Kajii Y, Nohno K, Sugano A, Funayama S, Katakura A, Nomura T, et al. Factors associated with xerostomia in perimenopausal women. J Obstet Gynaecol Res. 2021;47(10):3661\u20138.","journal-title":"J Obstet Gynaecol Res"},{"issue":"6","key":"2269_CR48","doi-asserted-by":"publisher","first-page":"e762","DOI":"10.4317\/medoral.24731","volume":"26","author":"A P\u00e9rez-Gonz\u00e1lez","year":"2021","unstructured":"P\u00e9rez-Gonz\u00e1lez A, Su\u00e1rez-Quintanilla JA, Otero-Rey E, Blanco-Carri\u00f3n A, G\u00f3mez-Garc\u00eda FJ, G\u00e1ndara-Vila P, Mart\u00edn-Biedma B, P\u00e9rez-Say\u00e1ns M. Association between xerostomia, oral and general health, and obesity in adults. A cross-sectional pilot study. Med Oral Patol Oral Cir Bucal. 2021;26(6):e762\u20139.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2269_CR49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.radonc.2019.05.023","volume":"138","author":"K Sommat","year":"2019","unstructured":"Sommat K, Hussain A, Ong WS, Yit NLF, Khoo JBK, Soong YL, et al. Clinical and dosimetric predictors of physician and patient reported xerostomia following intensity modulated radiotherapy for nasopharyngeal cancer\u2014a prospective cohort analysis. Radiother Oncol. 2019;138:149\u201357.","journal-title":"Radiother Oncol"},{"issue":"2","key":"2269_CR50","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ijrobp.2006.05.002","volume":"66","author":"A Meirovitz","year":"2006","unstructured":"Meirovitz A, Murdoch-Kinch CA, Schipper M, Pan C, Eisbruch A. Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2006;66(2):445\u201353.","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-022-02269-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-022-02269-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-022-02269-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:33:14Z","timestamp":1700717594000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-022-02269-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,17]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2269"],"URL":"https:\/\/doi.org\/10.1186\/s12903-022-02269-0","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,17]]},"assertion":[{"value":"19 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The informed consents were obtained from the participants and this study was approved by Zhongshan City People\u2019s Hospital. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"239"}}