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All rats were examined for the signs of MRONJ 8 weeks post-dental extraction. Forty-nine rats with positive signs of MRONJ were appointed to seven different groups as follows: control (Ctrl); surgery alone (Surg); surgery and PBM (Surg\u2009+\u2009PBM); surgery and A-PRF insertion (Surg\u2009+\u2009APRF); surgery and L-PRF insertion (Surg\u2009+\u2009LPRF); surgery, A-PRF insertion, and PBM (Surg\u2009+\u2009APRF\u2009+\u2009PBM); surgery, L-PRF insertion, and PBM (Surg\u2009+\u2009LPRF\u2009+\u2009PBM). Euthanasia was carried out 30\u00a0days after the last treatment session. The lesions' healing was evaluated clinically, histologically, and radiographically. Data were analyzed using STATA software version 14, and the statistical significance level was set at 5% for all cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to the present study, A-PRF and L-PRF treatment resulted in significant improvements in clinical, histological, and radiographical parameters compared to the Ctrl group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). The PBM also decreased wound dimensions and the number of empty lacunae compared to the Ctrl group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Surg\u2009+\u2009APRF\u2009+\u2009PBM and Surg\u2009+\u2009LPRF\u2009+\u2009PBM were the only groups that presented a significantly higher mean number of osteocytes (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). No significant differences were observed between A-PRF and L-PRF treatment groups (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical resection followed by applying A-PRF or L-PRF reinforced by PBM showed optimal wound healing and bone regeneration in MRONJ lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-022-02275-2","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T05:02:54Z","timestamp":1655528574000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Complementarity of surgical therapy, photobiomodulation, A-PRF and L-PRF for management of medication-related osteonecrosis of the jaw (MRONJ): an animal study"],"prefix":"10.1186","volume":"22","author":[{"given":"Mohammad Reza","family":"Jamalpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-9629","authenticated-orcid":false,"given":"Shiva","family":"Shahabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Baghestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Shokri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokoofeh","family":"Jamshidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Khazaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"issue":"10100","key":"2275_CR1","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","volume":"390","author":"T Vos","year":"2017","unstructured":"Vos T, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, Abdulkader RS, Abdulle AM, Abebo TA, Abera SF. 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