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Many factors have been found to be related to the disease however, the underlying mechanism is yet to be fully elucidated. Physical activity is widely known to modulate pain intensity in various pain disorders. However, literature suggesting the association between physical activity and signs and symptoms of TMD are limited.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and design<\/jats:title>\n                <jats:p>The \u201cPhysical Activity in TMD (PAT)\u201d is a prospective study on TMD patients that aims to determine how daily physical activity and sleep duration affect long-term TMD prognosis following conventional treatment. To analyze such effects, objective data on daily physical activity levels will be collected along with clinical indices including mouth opening ranges and masticatory muscle palpation responses from adult Koreans diagnosed with TMD following standardized diagnostic procedures. Well-known comorbidities of TMD will be extensively evaluated based on validated structured questionnaires on sleep quality, fatigue level, widespread pain, psychological status including depression and anxiety, autonomic symptoms, and health-related quality of life. The collected data will be analyzed according to TMD pain severity and physical activity level, and correlations among physical activity indices and long-term TMD prognosis will be investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>In this longitudinal prospective study of adult Koreans diagnosed with TMD following standardized diagnostic procedures, primary outcomes include physical activity levels and long-term TMD clinical outcomes and secondary outcomes include disability from pain and related comorbidity levels. Results and analysis are ongoing. The results of this study will provide reliable data for future research and establish clinical guidelines that will allow cause-related, patient-tailored personalized medicine for TMD.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>: Clinical Research Information Service (Registration number: KCT0007107). Registered March 22 2022 <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cris.nih.go.kr\/cris\/search\/detailSearch.do?search_lang=E&amp;focus=reset_12&amp;search_page=M&amp;pageSize=10&amp;page=undefined&amp;seq=21420&amp;status=5&amp;seq_group=21420\">https:\/\/cris.nih.go.kr\/cris\/search\/detailSearch.do?search_lang=E&amp;focus=reset_12&amp;search_page=M&amp;pageSize=10&amp;page=undefined&amp;seq=21420&amp;status=5&amp;seq_group=21420<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-022-02428-3","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T19:03:43Z","timestamp":1663182223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Does physical activity level have an impact on long-term treatment response in temporomandibular disorders: protocol for a prospective study"],"prefix":"10.1186","volume":"22","clinical-trial-number":[{"clinical-trial-number":"kct0007107","registry":"10.18810\/cris"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-9579","authenticated-orcid":false,"given":"Youngwoo","family":"Chun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-8437","authenticated-orcid":false,"given":"Jung Hwan","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7021","authenticated-orcid":false,"given":"Ji Woon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"2428_CR1","unstructured":"https:\/\/www.nidcr.nih.gov\/research\/data-statistics\/facial-pain\/prevalence, Accessed 7 Feb 7 2022."},{"issue":"4","key":"2428_CR2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.15386\/cjmed-485","volume":"88","author":"AM Chisnoiu","year":"2015","unstructured":"Chisnoiu AM, Picos AM, Popa S, et al. 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