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The Maxillary Skeletal Expander (MSE) appliance was used to perform MARPE in all patients. Their vital signs (heart rate, mean arterial pressure (MAP), and peripheral oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      )) were recorded. The ONSD was measured by US immediately before the first screw activation (T0), and the measurements were repeated 1\u00a0min (T1) and 10\u00a0min (T2) after the first activation. In the last session of active MARPE therapy, the same measurement protocol was performed as in the first activation session (T3, T4, and T5). The patients\u2019 perceptions of pain during the screw activation were also noted at T1 and T4 using a four-category verbal rating scale (VRS-4). The significant differences among different time intervals performed with the Friedman test (for all tested variables; SpO2, MAP, Heart Rate, VRS-4 and ONSD). Spearman correlation test was used for VRS-4 and ONSD comparisons. The statistical significance level was accepted as\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ONSD values \u200b\u200b(T1 and T4) relatively increased within 1\u00a0min after screw activation but did not reach a statistically significant level (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). There was also no significant difference between the initial (T0) and the final (T5) ONSD values \u200b\u200bduring the active MARPE therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is no changes or alterations in intracranial pressure in late adolescents during active MARPE therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-022-02482-x","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T11:02:43Z","timestamp":1666177363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does MARPE therapy have effects on intracranial pressure? a clinical study"],"prefix":"10.1186","volume":"22","author":[{"given":"Baris","family":"Baser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Bolukbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Uzlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Duhan","family":"Ozbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"2482_CR1","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/0002-9416(82)90318-9","volume":"82","author":"DI Chaconas","year":"1982","unstructured":"Chaconas DI, Chaconas SJ, Caputo AA. 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The study procedures were approved by the Clinic Research Ethics Commission of Karadeniz Technical University Faculty of Medicine Scientific (24237859-263, 17\/03\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Was obtained from all subjects and\/or their legal guardian(s) for participation and publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"1 Department of Orthodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. 2 Department of Ophtalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. 3 Department of Ophtalmology, Erzurum Regional Education and Research Hospital,Turkey.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author information"}}],"article-number":"450"}}