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All patients received standard non-surgical periodontal therapy, and were randomly divided into two groups of intervention and control by a table of random numbers (<jats:italic>n<\/jats:italic>\u2009=\u200915). The intervention group consumed 1000\u00a0mg natural fish oil soft-gels daily (300\u00a0mg Omega-3 marine triglycerides, 180\u00a0mg Eicosapentaenoic acid and 120\u00a0mg Docosahexaenoic acid) while the control group used soft-gels contained only some soybean oil for 3 months. Clinical attachment loss (CAL), probing depth (PD), and bleeding index (BI) were recorded at baseline (before the intervention) and after 3 months. The two groups were compared regarding the clinical parameters by t-test (alpha\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three clinical parameters decreased in both groups at 3 months compared with baseline (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). The improvement in PD and CAL in the intervention group was significantly greater than that in the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001); however, the difference in BI was not significant between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.283).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Omega-3 supplementation as an adjunct to non-surgical periodontal therapy significantly improved the clinical parameters in periodontitis patients compared to soybean oil supplements.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12903-022-02569-5","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:12:06Z","timestamp":1669162326000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in periodontitis patients: a randomized clinical trial"],"prefix":"10.1186","volume":"22","author":[{"given":"Fahimeh Rashidi","family":"Maybodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Fakhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Tavakoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"issue":"2","key":"2569_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/jcpe.12650","volume":"44","author":"P Bouchard","year":"2017","unstructured":"Bouchard P, Carra MC, Boillot A, Mora F, Rang\u00e9 H. 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