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The present study aimed to compare the effects of 1 and 2% pilocarpine mouthwash on xerostomic participants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this double-blind clinical trial study, 48 subjects with xerostomia were randomly divided into three groups to measure the effects of 1 and 2% pilocarpine and placebo mouthwashes on saliva levels. The amount of saliva in the 1st and 14th days was measured at 0, 45, 60, and 75 mins, while participants used their mouthwash three times a day for 14\u2009days. On the 1st and 14th days, they filled out the information forms on xerostomia and the medicine\u2019s side effects before and after the intervention.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>On the 1st day, the mean salivary flow at 45, 60, and 75 mins in the 2 and 1% pilocarpine mouthwash were significantly higher than in the placebo mouthwash group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). On the 14th day, the mean salivary flow time at 45 mins in the 2% pilocarpine mouthwash group was significantly higher than in the placebo mouthwash group (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Furthermore, the mean salivary flow at 60 and 75 mins in the 2% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 1% pilocarpine mouthwash (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) was significantly higher than in the placebo group. Moreover, the salivary flow in the 2% pilocarpine mouthwash group was significantly higher than the 1% pilocarpine mouthwash (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) during these two times. No side effects were observed in any of the subjects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The study showed that 5\u2009ml of 2 and 1% pilocarpine mouthwash for 2 weeks increased salivary flow in xerostomic participants compared to placebo without any side effects.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-022-02576-6","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T18:14:19Z","timestamp":1669918459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of the 1 and 2% pilocarpine mouthwash in a xerostomic population: a randomized clinical trial"],"prefix":"10.1186","volume":"22","author":[{"given":"Babak","family":"Motamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Alaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Jahandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad Kharazi","family":"Fard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"issue":"10","key":"2576_CR1","doi-asserted-by":"publisher","first-page":"e994","DOI":"10.4317\/jced.58415","volume":"13","author":"W Sarideechaigul","year":"2021","unstructured":"Sarideechaigul W, Priprem A, Limsitthichaikoon S, et al. 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After explaining the steps to the patients, all eligible volunteers were asked to complete and sign the informed consent form to participate in the study.The protocol of the study is available on:","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare they have no conflicts of interest in the matter of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"548"}}