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This prospective randomized controlled trial (RCT) was conducted to evaluate the effectiveness of botulinum toxin type-A (BTX-A) and low level laser therapy (LLLT) in comparison to anterior repositioning appliance (ARA) for the treatment of DDwR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 27 patients were randomly allocated to 3 groups; ARA (control group), BTX-A, and LLLT; with 9 patients each. All patients were evaluated before and 3\u00a0months after the treatment using a visual analogue scale (VAS) and magnetic resonance imaging (MRI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At 3\u00a0months follow-up, all groups showed a significant reduction in pain assessed by VAS (<jats:italic>P<\/jats:italic>\u2009=\u20090.007). Measured on MRI, there was a significant improvement in disc position and joint space index (JSI) in BTX-A group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>P<\/jats:italic>\u2009=\u20090.011) and LLLT group (<jats:italic>P<\/jats:italic>\u2009=\u20090.002, <jats:italic>P<\/jats:italic>\u2009=\u20090.017) in comparison to the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.087, <jats:italic>P<\/jats:italic>\u2009=\u20090.066) respectively. As for time of recovery, a statistically significant difference was observed in BTX-A group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and LLLT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) group in comparison to ARA group, which showed the most prolonged duration for reduction of DDwR symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We concluded that BTX-A and LLLT could be considered effective alternative treatment modalities to ARA regarding reducing joint pain, clicking, and improving disc position in patients with symptomatic DDwR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This prospective double-blinded RCT has been registered at ClinicalTrials.gov with identification number: NCT05194488, 18\/1\/2022.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-022-02579-3","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T18:15:24Z","timestamp":1669918524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial"],"prefix":"10.1186","volume":"22","author":[{"given":"Nermeen A.","family":"Rady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam M.","family":"Bahgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abdel-Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2579_CR1","unstructured":"de Leeuw R, Klasser GD (5th eds.) 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