{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:23:11Z","timestamp":1768072991955,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Program of the new clinical techniques of Peking University School and Hospital of Stomatology","award":["PKUSSNCT-20A05"],"award-info":[{"award-number":["PKUSSNCT-20A05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ensuring high accuracy in multimodal image fusion for oral and maxillofacial tumors is crucial before further application. The aim of this study was to explore the factors influencing the accuracy of multimodal image fusion for oral and maxillofacial tumors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Pairs of single-modality images were obtained from oral and maxillofacial tumor patients, and were fused using a proprietary navigation system by using three algorithms (automatic fusion, manual fusion, and registration point-based fusion). Fusion accuracy was evaluated including two aspects\u2014overall fusion accuracy and tumor volume fusion accuracy\u2014and were indicated by mean deviation and fusion index, respectively. Image modality, fusion algorithm, and other characteristics of multimodal images that may have potential influence on fusion accuracy were recorded. Univariate and multivariate analysis were used to identify relevant affecting factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ninety-three multimodal images were generated by fusing 31 pairs of single-modality images. The interaction effect of image modality and fusion algorithm (<jats:italic>P<\/jats:italic>\u2009=\u20090.02, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and thinner slice thickness (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) were shown to significantly influence the overall fusion accuracy. The tumor volume (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), tumor location (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), and image modality (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) were significant influencing factors for tumor volume fusion accuracy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To ensure high overall fusion accuracy, manual fusion was not preferred in CT\/MRI image fusion, and neither was automatic fusion in image fusion containing PET modality. Using image sets with thinner slice thickness could increase overall fusion accuracy. CT\/MRI fusion yielded higher tumor volume fusion accuracy than fusion containing PET modality. The tumor volume fusion accuracy should be taken into consideration during image fusion when the tumor volume is small and the tumor is located in the mandible.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-022-02679-0","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T18:03:06Z","timestamp":1672423386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Factors influencing the accuracy of multimodal image fusion for oral and maxillofacial tumors: a retrospective study"],"prefix":"10.1186","volume":"22","author":[{"given":"Lei-Hao","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"issue":"5","key":"2679_CR1","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.otohns.2005.11.015","volume":"134","author":"JL Leong","year":"2006","unstructured":"Leong JL, Batra PS, Citardi MJ. 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The study was approved by the Biomedical Institutional Review Board of Peking University School of Stomatology (approval number: PKUSSIRB-202054021). Written informed consent was not required for this study because all of the included patients in the present investigation were collected retrospectively. All of the patients enrolled in this study have received treatment in our department, and they have signed informed consent form before treatment, where they consented that their image data could been acquired for research use in our department. Based on these reasons, the application for free informed consent has been approved by the Biomedical Institutional Review Board of Peking University School of Stomatology. Exemption of informed consent will not affect the rights and health of included patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"659"}}