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Thus, the aim of this study was to evaluatethe effect of EDDY and manual dynamic activation (MDA) techniques on postoperative pain (PP) associated with retreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety patients scheduled for retreatment were treated at a single visit. Non-vital mandibular premolar teeth diagnosed with asymptomatic apical periodontitis were included in this study. The patients were divided into two groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945) on the basis of the need for additional irrigation activation procedures (EDDY and MDA). The patients\u2019 post-treatment pain levels were asked to rate the intensity of their pain on a 10-point numerical rating scale (NRS) at the 12th, 24th, 48th, and 72nd h and 7 days.The data were analyzed using the chi-square and Wilcoxon signed-rank test was used for within-group comparisons and Mann Whitney U test was used to compare the groups by time period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The difference in postoperative pain intensity between two groups was statistically significant at 12, 24, 48, and 72\u00a0h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). There was no significant difference at 7 days. Moreover, no statistically significant difference was found between the two groups in terms of gender and analgesic medication intake (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Pain intensity after the treatment was lesser in the MDA groupthanin the EDDY group at 12, 24, 48, and 72\u00a0h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study could lead us to conclude that the two activation systems can be used during endodontic retreatment with no difference at PP 7 days later. However, a comparison of the groups indicated that the EDDY resulted in significantly more PP at 12, 24, 48, and 72\u00a0h.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration<\/jats:italic>\n                      \u00a0ClinicalTrials.gov Identifier: NCT04726670.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-022-02702-4","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:03:50Z","timestamp":1672711430000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of EDDY and manual dynamic activation techniques on postoperative pain in non-surgical retreatment: a randomized controlled trial"],"prefix":"10.1186","volume":"23","clinical-trial-number":[{"clinical-trial-number":"nct04726670","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Selen","family":"\u0130nce-Yusufo\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan B\u00fc\u015fra","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fah","family":"Uslu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Helvacioglu-Yigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"issue":"5","key":"2702_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/01.don.0000145035.85272.7c","volume":"31","author":"R McGurkin-Smith","year":"2005","unstructured":"McGurkin-Smith R, Trope M, Caplan D, Sigurdsson A. 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The Ethics Committee approved Informed Consent dismissal. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.Informed consent was obtained from all subjects and\/or their legal guardian(s).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3"}}