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Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs), their related genes (Hub genes), transcription factors (TFs), signaling pathways, enrichment functions, and compounds, and searching for genetic commonalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The miRNAs expression datasets of OSCC and PD were searched from the GEO database. The miRNA and related crosstalk mechanism between OSCC and PD was obtained through a series of analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      hsa-mir-497, hsa-mir-224, hsa-mir-210, hsa-mir-29c, hsa-mir-486-5p, and hsa-mir-31are the top miRNA nodes in Co-DEmiRNA-Target networks. The most significant candidate miRNA dysregulation genes are\n                      <jats:italic>ZNF460<\/jats:italic>\n                      ,\n                      <jats:italic>FBN1<\/jats:italic>\n                      ,\n                      <jats:italic>CDK6<\/jats:italic>\n                      ,\n                      <jats:italic>BTG2<\/jats:italic>\n                      , and\n                      <jats:italic>CBX6<\/jats:italic>\n                      , while the most important dysregulation TF includes HIF1A, TP53, E2F1, MYCN, and JUN. 5-fluorouracil, Ginsenoside, Rh2, and Formaldehyde are the most correlated compounds. Enrichment analysis revealed cancer-related pathways and so on.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The comprehensive analysis reveals the interacting genetic and molecular mechanism between OSCC and PD, linking both and providing a foundation for future basic and clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-022-02704-2","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T09:03:53Z","timestamp":1673600633000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma"],"prefix":"10.1186","volume":"23","author":[{"given":"Zhengrui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"issue":"4","key":"2704_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3322\/caac.21609","volume":"70","author":"F Bray","year":"2020","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al. 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