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Cephalometric radiographs were obtained before distraction (T1), after the consolidation period (T2) and after orthodontic treatment or before orthognathic surgery (T3). Thirty-one cephalometric variables (12 skeletal, 9 dental, and 10 soft tissue variables) were used to evaluate changes in the dentofacial structures and the soft tissue profile. Friedman and Wilcoxon tests were applied to identify significant differences in hard and soft tissue changes during the T1\u2013T2, T2\u2013T3, and T1\u2013T3 periods.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All patients successfully underwent MASDO without serious complications. From T1 to T2, forward movements of ANS and A (FH \u22a5 N\u2013A, VRL\u2013ANS and VRL\u2013A) were significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Significant increases in SNA and ANB were noted. Significant upward movement of points ANS (CFH\u2013ANS) and A (CFH\u2013A) was observed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). After distraction, a significant decrease in overjet and an increase in overbite were obtained (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Anterior tipping of the upper incisors (U1\/ANS\u2013PNS and U1\/SN) was observed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The soft tissue points of Pn, Sn, Ss, and ls showed significant anterior movement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, a significant increase in the nasolabial angle was measured (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). All of the above data showed no statistically significant changes between T2 and T3 (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>MASDO using a miniscrew assisted tooth-borne distractor presented significant maxillary advancement and favorable long-term stability in treating CLP patients with maxillary hypoplasia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-023-03038-3","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T06:02:09Z","timestamp":1684908129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Maxillary anterior segmental distraction osteogenesis to correct maxillary hypoplasia and dental crowding in cleft palate patients: a preliminary study"],"prefix":"10.1186","volume":"23","author":[{"given":"Liwen","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wener","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"3038_CR1","doi-asserted-by":"crossref","unstructured":"Zhang Z, Zhang P, Li S, Cheng J, Yuan H, Jiang H. 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Written informed consent was obtained from the parents. All methods involved were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the parents for the publication of clinical details.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"321"}}