{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:12:42Z","timestamp":1792674762943,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recurrent Aphthous Stomatitis (RAS) is painful oral ulceration frequently treated with topical steroids. There is limited published evidence for the efficacy of any treatment for RAS and there remains a need for longitudinal randomised clinical trials to evaluate and compare the effectiveness of different therapies in the management of RAS. The aim of the current project was to assess the efficacy of betamethasone mouthwash and colchicine tablets, individually and combined, for the treatment of RAS, and to establish the optimum treatment period necessary for a significant reduction in the disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A randomised, prospective, parallel-group clinical trial was conducted over one year, to compare the efficacy of three therapies in RAS. One hundred and six patients were randomized into three groups; 35 received betamethasone mouthwash, 35 had colchicine tablets and 36 received both therapies. The response was evaluated quantitatively every 3 months for 1 year, using the Ulcer Severity Score (USS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For all three treatment regimes, the mean USS decreased by about 30% in the first 3 months (p\u2009&lt;\u20090.001). Further improvement was noted for up to 9 months. At the end of the study, the mean USS had improved by 50% from 34.9\u2009\u00b1\u20097.2 before treatment to 17.5\u2009\u00b1\u20098.9 after treatment (p\u2009&lt;\u20090.001). Of included participants, 86% showed significant clinical improvement by the end of the study. There were no significant differences in outcomes between the three regimes (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This clinical trial has provided evidence for the efficacy of betamethasone mouthwash and for colchicine tablets in the treatment of RAS and has shown that at least six months of treatment may be required for optimum effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number:<\/jats:title>\n                    <jats:p>\n                      ISRCTN3267716.\n                      <jats:bold>Date of clinical trial registration:<\/jats:bold>\n                      15\/04\/2018\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-023-03335-x","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:01:32Z","timestamp":1696338092000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Topical betamethasone and systemic colchicine for treatment of recurrent aphthous stomatitis: a randomised clinical trial"],"prefix":"10.1186","volume":"23","author":[{"given":"Surab","family":"Alsahaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khlood A.","family":"Alkurdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Challacombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar R.","family":"Tappuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"issue":"2","key":"3335_CR1","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.4317\/jced.51042","volume":"5","author":"MJ Abdullah","year":"2013","unstructured":"Abdullah MJ. 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The trial was conducted in compliance with the principles of the Declaration of Helsinki (2013), the principles of International Council for Harmonisation- Good Clinical Practice (ICH-GCP), and all the applicable regulatory requirements. The study was approved by the Guy\u2019s Research Ethics Committee and the Medicines and Healthcare Products Regulatory Agency. This clinical trial was fully registered with The International Standard Randomised Clinical Trial Number (ISRCTN). Written informed consent was obtained from all participants. This manuscript was constructing with accordance to the CONSORT 2010 checklist for reporting clinical trials (present in the related manuscript files).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approvaland consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"709"}}