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Visfatin is a pleiotropic adipokine that exerts metabolic and immune functions. Studies have shown visfatin played roles in the development of periodontitis. The present study aims to compare the levels of visfatin in body fluids including serum, saliva, and gingival crevicular fluid (GCF) between periodontitis patients and healthy individuals, and to elucidate the alteration of visfatin levels after periodontal treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>The database searched included Pubmed, Embase, Web of Science, and Cochrane Library. According to the Eligibility criteria, the records were screened and the eligible studies were included. The methodological qualities of the included case-controlled studies were assessed according to the Newcastle\u2013Ottawa scale (NOS). The Methodological Index for Nonrandomized Studies (MINORS) was applied for assessing the qualities of the included clinical trials. The statistical analyses were processed using STATA 15.0.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty-three studies were included in the statistical analyses. The meta-analysis showed significantly elevated visfatin levels of GCF, serum, and saliva in the periodontitis population compared with the controls (GCF: SMD\u2009=\u20095.201, 95% CI: 3.886\u20136.516,\u00a0Z\u2009=\u20097.75, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; Serum: SMD\u2009=\u20097.417, 95% CI: 3.068\u201311.767,\u00a0Z\u2009=\u20093.34, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; Saliva: SMD\u2009=\u20092.683, 95% CI: 1.202\u20134.163,\u00a0Z\u2009=\u20093.34, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Visfatin levels of saliva serum and GCF were significantly decreased after periodontal treatment.<\/jats:p>\n                <jats:p>(Saliva: SMD\u2009=\u2009-1.338, 95% CI: -2.289\u20140.487,\u00a0Z\u2009=\u200939.77, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; Serum: SMD\u2009=\u2009-2.890, 95% CI: -5.300\u20130.480,\u00a0Z\u2009=\u20092.35, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; GCF: SMD\u2009=\u2009-6.075, 95% CI: -11.032\u20141.117,\u00a0Z\u2009=\u20092.40, <jats:italic>P<\/jats:italic>\u2009=\u20090.016;\u00a0I\u00a02\u2009=\u200995.9%,\u00a0<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Periodontitis elevated the visfatin levels in GCF, serum, and saliva. Additionally, GCF, serum, and saliva visfatin levels could be reduced after periodontal treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-023-03384-2","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T11:02:44Z","timestamp":1698318164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Periodontitis is associated with the increased levels of visfatin: a meta-analysis"],"prefix":"10.1186","volume":"23","author":[{"given":"Junfei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"issue":"1","key":"3384_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J. 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