{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:33:58Z","timestamp":1793496838628,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012306","name":"Universit\u00e0 degli Studi di Trieste","doi-asserted-by":"publisher","award":["Microgrant LR 2\/2011"],"award-info":[{"award-number":["Microgrant LR 2\/2011"]}],"id":[{"id":"10.13039\/501100012306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Radiomorphometric indices measured on Dental Panoramic Radiography (DPR) can reflect Bone Mineral Density (BMD). The aim of our study is to evaluate changes in DPR radiographic markers in patients undergoing antiresorptive therapy with denosumab and correlate them to BMD and serum bone turnover markers (BTM).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We evaluated two radiomorphometric indices: Mandibular Cortical Width (MCW) and Panoramic Mandibular Index (PMI), in patients undergoing antiresorptive therapy with denosumab at T0 (before starting the therapy) and at T1 (after 12 months), comparing results with a control group of healthy patients who performed two DPRs at a one-year time distance. Correlation analysis was performed in the denosumab group, as well as ROC curves were obtained for both indices.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study included 18 patients and 21 controls according to specific inclusion and exclusion criteria, matched by gender and age. Both MCW and PMI were significantly lower at T0 in the denosumab group, consistently with lower BMD. MCW showed significant correlation with femoral and lumbar DEXA and was significantly lower in patients with osteoporosis compared to osteopenia. Only PMI index increased significantly in the denosumab group from T0 to T1. After one year (T1), there weren\u2019t any differences between patients and controls for both indices. No significant correlations were found with BTMs. Sensitivity and specificity for MCW and PMI were also calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results show how CMW shows sufficient sensitivity and specificity to be used as a radiographic marker to screen and intercept patients with osteoporosis. PMI seems to be able to reflect changes in response to antiresorptive therapy with denosumab. Further studies are needed to confirm our hypothesis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-03870-1","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T14:02:38Z","timestamp":1705413758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in mandibular radiomorphometric indices in osteoporosis patients treated with denosumab: a retrospective case-control study"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-9439","authenticated-orcid":false,"given":"Katia","family":"Rupel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Dal Broi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bellassai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora Magdalena","family":"Bogdan Preda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Di Lenarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Biasotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"3870_CR1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/jama.285.6.785","volume":"285","author":"NIH Consensus Development Panel on Osteoporosis Prevention","year":"2001","unstructured":"NIH Consensus Development Panel on Osteoporosis Prevention. Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285:785\u201395. https:\/\/doi.org\/10.1001\/jama.285.6.785.","journal-title":"JAMA"},{"key":"3870_CR2","doi-asserted-by":"publisher","unstructured":"Kanis JA, Adachi JD, Cooper C, Clark P, Cummings SR, Diaz- Curiel M, Harvey N, Hiligsmann M, Papaioannou A, Pierroz DD, Silverman SL, Szulc P, Quality of Life Working Group of IOF. (2013) The Epidemiology and : Standardising the descriptive epidemiology of osteoporosis: recommendations from the Epidemiology and Quality of Life Working Group of IOF. Osteoporos Int 24:2763\u20132764. https:\/\/doi.org\/10.1007\/s00198-013-2413-7.","DOI":"10.1007\/s00198-013-2413-7"},{"key":"3870_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/1874210601509010303","volume":"9","author":"AA Bajoria","year":"2015","unstructured":"Bajoria AA, Ml A, Kamath G, Babshet M, Patil P, Sukhija P. Evaluation of Radiomorphometric Indices in Panoramic Radiograph - A Screening Tool. Open Dent J. 2015;9:303\u201310. https:\/\/doi.org\/10.2174\/1874210601509010303. PMID: 26464600; PMCID: PMC4598386.","journal-title":"Open Dent J"},{"key":"3870_CR4","doi-asserted-by":"publisher","unstructured":"Ledgerton D, Horner K, Devlin H, Worthington H. Panoramic mandibular index as a radiomorphometric tool: an assessment of precision. Dentomaxillofac Radiol. 1997;26(2):95\u2013100. https:\/\/doi.org\/10.1038\/sj.dmfr.4600215. PMID: 9442624.","DOI":"10.1038\/sj.dmfr.4600215"},{"key":"3870_CR5","doi-asserted-by":"publisher","unstructured":"Klemetti E, Kolmakov S, Kr\u00f6ger H. Pantomography in assessment of the osteoporosis risk group. Scand J Dent Res. 1994;102(1):68\u201372. https:\/\/doi.org\/10.1111\/j.1600-0722.1994.tb01156.x. PMID: 8153584.","DOI":"10.1111\/j.1600-0722.1994.tb01156.x"},{"issue":"5","key":"3870_CR6","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.tripleo.2006.02.023","volume":"102","author":"V Dutra","year":"2006","unstructured":"Dutra V, Devlin H, Susin C, Yang J, Horner K, Fernandes AR. Mandibular morphological changes in low bone mass edentulous females: evaluation of panoramic radiographs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(5):663\u20138. https:\/\/doi.org\/10.1016\/j.tripleo.2006.02.023.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"3870_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0030-4220(91)90314-3","volume":"71","author":"BW Benson","year":"1991","unstructured":"Benson BW, Prihoda TJ, Glass BJ. Variations in adult cortical bone mass as measured by a panoramic mandibular index. Oral Surg Oral Med Oral Pathol. 1991;71(3):349\u201356. https:\/\/doi.org\/10.1016\/0030-4220(91)90314-3.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"4","key":"3870_CR8","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1601-0825.2009.01615.x","volume":"16","author":"A Taguchi","year":"2010","unstructured":"Taguchi A. Triage screening for osteoporosis in dental clinics using panoramic radiographs. Oral Dis. 2010;16(4):316\u201327. https:\/\/doi.org\/10.1111\/j.1601-0825.2009.01615.x. Epub 2009 Aug 7. PMID: 19671082.","journal-title":"Oral Dis"},{"key":"3870_CR9","doi-asserted-by":"publisher","unstructured":"Taguchi A, Ohtsuka M, Nakamoto T, Suei Y, Kudo Y, Tanimoto K, Bollen AM. Detection of post-menopausal women with low bone mineral density and elevated biochemical markers of bone turnover by panoramic radiographs. Dentomaxillofac Radiol. 2008;37(8):433-7. https:\/\/doi.org\/10.1259\/dmfr\/85235532. PMID: 19033427.","DOI":"10.1259\/dmfr\/85235532"},{"key":"3870_CR10","doi-asserted-by":"publisher","unstructured":"Drozdzowska B, Pluskiewicz W, Tarnawska B. Panoramic-based mandibular indices in relation to mandibular bone mineral density and skeletal status assessed by dual energy X-ray absorptiometry and quantitative ultrasound. Dentomaxillofac Radiol. 2002;31(6):361-7. https:\/\/doi.org\/10.1038\/sj.dmfr.4600729. PMID: 12424634.","DOI":"10.1038\/sj.dmfr.4600729"},{"key":"3870_CR11","doi-asserted-by":"publisher","unstructured":"Heuchert J, Kozie\u0142 S, Spinek AE. Radiomorphometric indices of the mandible as indicators of decreased bone mineral density and osteoporosis - meta-analysis and systematic review. Osteoporos Int. 2023 Oct 23. https:\/\/doi.org\/10.1007\/s00198-023-06949-7. Epub ahead of print. PMID: 37870561.","DOI":"10.1007\/s00198-023-06949-7"},{"key":"3870_CR12","doi-asserted-by":"publisher","unstructured":"Lacey DL, Boyle WJ, Simonet WS, Kostenuik PJ, Dougall WC, Sullivan JK, San Martin J, Dansey R. Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. Nat Rev Drug Discov. 2012;11(5):401\u2009\u2013\u200919. https:\/\/doi.org\/10.1038\/nrd3705. PMID: 22543469.","DOI":"10.1038\/nrd3705"},{"issue":"8","key":"3870_CR13","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1056\/NEJMoa0809493","volume":"361","author":"SR Cummings","year":"2009","unstructured":"Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C, FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009;361(8):756\u201365. https:\/\/doi.org\/10.1056\/NEJMoa0809493. Epub 2009 Aug 11.","journal-title":"N Engl J Med"},{"key":"3870_CR14","doi-asserted-by":"publisher","unstructured":"Wang WY, Chen LH, Ma WJ, You RX. Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta-analysis of randomized controlled trials. Eur Rev Med Pharmacol Sci. 2023;27(17):8253\u20138268. https:\/\/doi.org\/10.26355\/eurrev_202309_33586. PMID: 37750653.","DOI":"10.26355\/eurrev_202309_33586"},{"issue":"4","key":"3870_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.eprac.2021.02.001","volume":"27","author":"NB Watts","year":"2021","unstructured":"Watts NB, Camacho PM, Lewiecki EM, Petak SM, AACE\/ACE Postmenopausal Osteoporosis Guidelines Task Force. American Association of Clinical Endocrinologists\/American College of Endocrinology Clinical Practice Guidelines for the diagnosis and treatment of postmenopausal Osteoporosis-2020 Update. Endocr Pract. 2021;27(4):379\u201380. Epub 2021 Feb 9. PMID: 33577971.","journal-title":"Endocr Pract"},{"issue":"16","key":"3870_CR16","doi-asserted-by":"publisher","first-page":"5998","DOI":"10.3390\/ijerph17165998","volume":"17","author":"G Campisi","year":"2020","unstructured":"Campisi G, Mauceri R, Bertoldo F, Bettini G, Biasotto M, Colella G, Consolo U, Di Fede O, Favia G, Fusco V, Gabriele M, Lo Casto A, Lo Muzio L, Marcian\u00f2 A, Mascitti M, Meleti M, Mignogna MD, Oteri G, Panzarella V, Romeo U, Santarelli A, Vescovi P, Marchetti C, Bedogni A. Medication-related osteonecrosis of Jaws (MRONJ) Prevention and diagnosis: Italian Consensus Update 2020. Int J Environ Res Public Health. 2020;17(16):5998. https:\/\/doi.org\/10.3390\/ijerph17165998. PMID: 32824826; PMCID: PMC7460511.","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"3870_CR17","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","volume":"80","author":"SL Ruggiero","year":"2022","unstructured":"Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and maxillofacial surgeons\u2019 position paper on medication-related osteonecrosis of the Jaws-2022 Update. J Oral Maxillofac Surg. 2022;80(5):920\u201343. Epub 2022 Feb 21. PMID: 35300956.","journal-title":"J Oral Maxillofac Surg"},{"issue":"25","key":"3870_CR18","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1200\/JCO.19.01186","volume":"37","author":"N Yarom","year":"2019","unstructured":"Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL, Migliorati CA, Khan A, Morrison A, Anderson H, Murphy BA, Alston-Johnson D, Mendes RA, Beadle BM, Jensen SB, Saunders DP. Medication-related osteonecrosis of the Jaw: MASCC\/ISOO\/ASCO Clinical Practice Guideline. J Clin Oncol. 2019;37(25):2270\u201390. Epub 2019 Jul 22. PMID: 31329513.","journal-title":"J Clin Oncol"},{"issue":"982","key":"3870_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1136\/pgmj.2007.057505","volume":"83","author":"GM Blake","year":"2007","unstructured":"Blake GM, Fogelman I. The role of DXA bone density scans in the diagnosis and treatment of osteoporosis. Postgrad Med J. 2007;83(982):509\u201317. https:\/\/doi.org\/10.1136\/pgmj.2007.057505. PMID: 17675543; PMCID: PMC2600106.","journal-title":"Postgrad Med J"},{"key":"3870_CR20","doi-asserted-by":"publisher","unstructured":"Lorentzon M, Branco J, Brandi ML, et al. Algorithm for the use of biochemical markers of bone turnover in the diagnosis, Assessment and Follow-Up of treatment for osteoporosis. Adv Ther. 2019 Aug;22. https:\/\/doi.org\/10.1007\/s12325-019-01063-9.","DOI":"10.1007\/s12325-019-01063-9"},{"issue":"6","key":"3870_CR21","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.sdentj.2022.05.006","volume":"34","author":"B Kiswanjaya","year":"2022","unstructured":"Kiswanjaya B, Priaminiarti M, Bachtiar-Iskandar HH. Three panoramic indices for identification of healthy older people at a high risk of osteoporosis. Saudi Dent J. 2022;34(6):503\u20138. https:\/\/doi.org\/10.1016\/j.sdentj.2022.05.006. Epub 2022 Jun 3. PMID: 36092521; PMCID: PMC9453511.","journal-title":"Saudi Dent J"},{"issue":"6","key":"3870_CR22","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/MAJ.0b013e3182972148","volume":"346","author":"S Mansour","year":"2013","unstructured":"Mansour S, AlGhamdi AS, Javed F, Marzouk H, Khan EA. Panoramic radiomorphometric indices as reliable parameters in predicting osteoporosis. Am J Med Sci. 2013;346(6):473\u20138. https:\/\/doi.org\/10.1097\/MAJ.0b013e3182972148. PMID: 23811576.","journal-title":"Am J Med Sci"},{"key":"3870_CR23","doi-asserted-by":"publisher","unstructured":"Khaitan T, Shukla AK, Gupta P, Naik SR. Is panoramic mandibular index a reliable marker in the evaluation of bone mineral density and sexual dimorphism?? J Forensic Dent Sci. 2019 Sep-Dec;11(3):133\u20136. https:\/\/doi.org\/10.4103\/jfo.jfds_92_19. Epub 2020 Jun 3. PMID: 32801584; PMCID: PMC7398367.","DOI":"10.4103\/jfo.jfds_92_19"},{"key":"3870_CR24","doi-asserted-by":"publisher","unstructured":"Leite AF, Figueiredo PT, Guia CM, Melo NS, de Paula AP. Correlations between seven panoramic radiomorphometric indices and bone mineral density in postmenopausal women. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(3):449\u2009\u2013\u200956. https:\/\/doi.org\/10.1016\/j.tripleo.2009.02.028. PMID: 20219601.","DOI":"10.1016\/j.tripleo.2009.02.028"},{"issue":"3","key":"3870_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.7860\/JCDR\/2014\/6844.4160","volume":"8","author":"P Govindraju","year":"2014","unstructured":"Govindraju P, Chandra P. Radiomorphometric indices of the mandible - an indicator of osteoporosis. J Clin Diagn Res. 2014;8(3):195\u20138. https:\/\/doi.org\/10.7860\/JCDR\/2014\/6844.4160. Epub 2014 Mar 15. PMID: 24783135; PMCID: PMC4003641.","journal-title":"J Clin Diagn Res"},{"issue":"10","key":"3870_CR26","doi-asserted-by":"publisher","first-page":"20120059","DOI":"10.1259\/dmfr.20120059","volume":"42","author":"CS Valerio","year":"2013","unstructured":"Valerio CS, Trindade AM, Mazzieiro ET, Amaral TP, Manzi FR. Use of digital panoramic radiography as an auxiliary means of low bone mineral density detection in post-menopausal women. Dentomaxillofac Radiol. 2013;42(10):20120059. https:\/\/doi.org\/10.1259\/dmfr.20120059. Epub 2013 Sep 4. PMID: 24005062; PMCID: PMC3853514.","journal-title":"Dentomaxillofac Radiol"},{"key":"3870_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11282-009-0015-z","volume":"25","author":"A Gulsahi","year":"2009","unstructured":"Gulsahi A, \u00d6zden \u015e, \u0130lker Cebeci A, et al. The relationship between panoramic radiomorphometric indices and the femoral bone mineral density of edentulous patients. Oral Radiol. 2009;25:47\u201352. https:\/\/doi.org\/10.1007\/s11282-009-0015-z.","journal-title":"Oral Radiol"},{"key":"3870_CR28","unstructured":"Marandi S, Bagherpour A, Imanimoghaddam M, Hatef M, Haghighi A. Panoramic-based mandibular indices and bone mineral density of femoral neck and lumbar vertebrae in women. J Dent (Tehran). 2010 Spring;7(2):98\u2013106. Epub 2010 Jun 30. PMID: 21998782; PMCID: PMC3184742."},{"issue":"1","key":"3870_CR29","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bone.2006.07.025","volume":"40","author":"K Karayianni","year":"2007","unstructured":"Karayianni K, Horner K, Mitsea A, Berkas L, Mastoris M, Jacobs R, Lindh C, van der Stelt PF, Harrison E, Adams JE, Pavitt S, Devlin H. Accuracy in osteoporosis diagnosis of a combination of mandibular cortical width measurement on dental panoramic radiographs and a clinical risk index (OSIRIS): the OSTEODENT project. Bone. 2007;40(1):223\u20139. https:\/\/doi.org\/10.1016\/j.bone.2006.07.025. Epub 2006 Sep 18. PMID: 16979965.","journal-title":"Bone"},{"key":"3870_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5671\/ca.45.1.4","volume":"45","author":"B Popi\u0107","year":"2021","unstructured":"Popi\u0107 B, Holik D, Kopi\u0107 V, Dinjar K, Milosti\u0107-Srb A, Nuji\u0107 D, D\u017eelalija B. The Radiomorphometric indices of the Mandible as a screening method for early detection of osteoporosis in Postmenopausal Women. Coll Antropol. 2021;45:31\u20137. https:\/\/doi.org\/10.5671\/ca.45.1.4.","journal-title":"Coll Antropol"},{"key":"3870_CR31","doi-asserted-by":"publisher","first-page":"6577","DOI":"10.1007\/s00784-023-05263-0","volume":"27","author":"A Teterina","year":"2023","unstructured":"Teterina A, Niratisairak S, Morseth B, et al. General and local predictors of mandibular cortical bone morphology in adult females and males: the seventh survey of the Troms\u00f8 Study. Clin Oral Invest. 2023;27:6577\u201387. https:\/\/doi.org\/10.1007\/s00784-023-05263-0.","journal-title":"Clin Oral Invest"},{"key":"3870_CR32","doi-asserted-by":"publisher","unstructured":"Management of Osteoporosis in Postmenopausal Women: The 2021 Position Statement of The North American Menopause Society\u2019\u2019 Editorial Panel. Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society. Menopause. 2021;28(9):973\u2013997. https:\/\/doi.org\/10.1097\/GME.0000000000001831. PMID: 34448749.","DOI":"10.1097\/GME.0000000000001831"},{"key":"3870_CR33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s12325-021-01936-y","volume":"39","author":"DL Kendler","year":"2022","unstructured":"Kendler DL, Cosman F, Stad RK, et al. Denosumab in the treatment of osteoporosis: 10 years later: a narrative review. Adv Ther. 2022;39:58\u201374. https:\/\/doi.org\/10.1007\/s12325-021-01936-y.","journal-title":"Adv Ther"},{"key":"3870_CR34","doi-asserted-by":"crossref","unstructured":"Reid IR, Billington EO. Drug therapy for osteoporosis in older adults. Lancet. 2022;399(10329):1080\u20131092. doi: 10.1016\/S0140-6736(21)02646-5. Erratum in: Lancet. 2022;400(10354):732. PMID: 35279261.","DOI":"10.1016\/S0140-6736(21)02646-5"},{"issue":"2","key":"3870_CR35","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1373\/clinchem.2016.259085","volume":"63","author":"MB Greenblatt","year":"2017","unstructured":"Greenblatt MB, Tsai JN, Wein MN. Bone turnover markers in the diagnosis and monitoring of metabolic bone disease. Clin Chem. 2017;63(2):464\u201374. https:\/\/doi.org\/10.1373\/clinchem.2016.259085. Epub 2016 Dec 9. PMID: 27940448; PMCID: PMC5549920.","journal-title":"Clin Chem"},{"issue":"2","key":"3870_CR36","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.semarthrit.2011.01.005","volume":"41","author":"T Funck-Brentano","year":"2011","unstructured":"Funck-Brentano T, et al. Clinical utility of serum bone turnover markers in postmenopausal osteoporosis therapy monitoring: a systematic review. Semin Arthritis Rheum. 2011;41(2):157\u201369. https:\/\/doi.org\/10.1016\/j.semarthrit.2011.01.005. Epub 2011 Apr 19. PMID: 21507464.","journal-title":"Semin Arthritis Rheum"},{"issue":"7","key":"3870_CR37","doi-asserted-by":"publisher","first-page":"20230284","DOI":"10.1259\/dmfr.20230284","volume":"52","author":"N Turosz","year":"2023","unstructured":"Turosz N, Ch\u0119ci\u0144ska K, Ch\u0119ci\u0144ski M, Brzozowska A, Nowak Z, Sikora M. Applications of artificial intelligence in the analysis of dental panoramic radiographs: an overview of systematic reviews. Dentomaxillofac Radiol. 2023;52(7):20230284. https:\/\/doi.org\/10.1259\/dmfr.20230284. Epub 2023 Sep 4. PMID: 37665008; PMCID: PMC10552133.","journal-title":"Dentomaxillofac Radiol"},{"issue":"1","key":"3870_CR38","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.jds.2020.06.019","volume":"16","author":"SB Khanagar","year":"2021","unstructured":"Khanagar SB, Al-Ehaideb A, Maganur PC, Vishwanathaiah S, Patil S, Baeshen HA, Sarode SC, Bhandi S. Developments, application, and performance of artificial intelligence in dentistry - A systematic review. J Dent Sci. 2021;16(1):508\u201322. https:\/\/doi.org\/10.1016\/j.jds.2020.06.019. Epub 2020 Jun 30. PMID: 33384840; PMCID: PMC7770297.","journal-title":"J Dent Sci"},{"key":"3870_CR39","doi-asserted-by":"publisher","unstructured":"Kapoor N, Cherian KE, Pramanik BK, Govind S, Winford ME, Shetty S, Thomas N, Paul TV. Association between Dental Health and osteoporosis: a study in South Indian Postmenopausal women. J Midlife Health 2017 Oct-Dec;8(4):159\u201362. https:\/\/doi.org\/10.4103\/jmh.JMH_21_17. PMID: 29307976; PMCID: PMC5753495.","DOI":"10.4103\/jmh.JMH_21_17"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-03870-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-024-03870-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-03870-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T14:03:13Z","timestamp":1705413793000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-024-03870-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3870"],"URL":"https:\/\/doi.org\/10.1186\/s12903-024-03870-1","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]},"assertion":[{"value":"24 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the principles outlined in the Declaration of Helsinki. The protocol was reviewed and approved by the University of Trieste Ethics Committee (129\/2023). Only subjects who have given written informed consent to the use of their clinical data, made anonymous, for the purpose of clinical and epidemiological research were included.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"89"}}