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This study was performed to investigate any possible relationship between \u2212\u20091031(T\/C) polymorphism\u00a0(rs1799964) of the tumor necrosis factor \u03b1 (TNF-\u03b1) gene with the risk and severity of oral lichen planus (OLP) disease among an Iranian population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Saliva samples were collected from 100 patients with OLP and a similar number of healthy controls (age and sex-matched). Then, DNA was extracted from the collected samples for genotyping TNF-\u03b1-1031 T\/C polymorphism using the PCR-CTPP method. The results were assessed using SPSS software.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The findings revealed a significantly higher prevalence of the C allele in OLP patients (53%) compared to healthy controls (36%), suggesting an association between TNF-alpha gene polymorphism and OLP. A multivariate logistic regression analysis supported this finding, as the presence of the C allele was significantly associated with an increased risk of OLP [\u03c72\u2009=\u20094.17, <jats:italic>p<\/jats:italic>\u2009=\u20090.04, 95% CI\u2009=\u20091.01\u20132.65, OR\u2009=\u20091.64]. However, our data indicated no significant association between TNF-alpha-1031 T\/C gene polymorphism and OLP severity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These findings provide the first evidence supporting a possible role of TNF-\u03b1-1031 T\/C gene polymorphism in OLP susceptibility in the Iranian population. The findings of this study demonstrate a positive association between TNF-\u03b1-1031\u00a0C\/T allele distribution and the risk of OLP disease in the Iranian population. Therefore, carrying the C allele may increase the susceptibility to OLP disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-03939-x","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T15:04:54Z","timestamp":1707145494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the association between TNF-\u03b1-1031 T\/C polymorphism with oral lichen planus disease"],"prefix":"10.1186","volume":"24","author":[{"given":"Mohammad Hesam","family":"Marabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Mozaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haniyeh","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Hatami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8592-7651","authenticated-orcid":false,"given":"Kheirollah","family":"Yari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"issue":"6","key":"3939_CR1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1601-0825.2005.01142.x","volume":"11","author":"D Eisen","year":"2005","unstructured":"Eisen D, Carrozzo M, Bagan Sebastian JV, Thongprasom K. 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