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This study explored the possible prognostic value of miRNAs for TSCC based on published research.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A comprehensive literature search of multiple databases was conducted according to predefined eligibility criteria. Data were extracted from the included studies by two researchers, and HR results were determined based on Kaplan\u2012Meier curves according to the Tierney method. The Newcastle\u2012Ottawa Scale (NOS) and GRADE (Grading of Recommendations Assessment, Development, and Evaluation) pro-GDT were applied to assess the quality of all studies. Publication bias was estimated by funnel plot, Egger\u2019s rank correlation test and sensitivity analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eleven studies (891patients) were included, of which 6 reported up-regulated miRNAs and 7 mentioned down-regulated miRNAs. The pooled hazard ratio (HR) from the prognostic indicator overall survival (OS) was 1.34 (1.25\u20131.44), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001, indicating a significant difference in miRNA expression between TSCC patients with better or worse prognosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>MiRNAs may have high prognostic value and could be used as prognostic biomarkers of TSCC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04182-0","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T07:01:39Z","timestamp":1711868499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["MicroRNA expression as a prognostic biomarker of tongue squamous cell carcinoma (TSCC): a systematic review and meta-analysis"],"prefix":"10.1186","volume":"24","author":[{"given":"Yiwei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"issue":"1","key":"4182_CR1","doi-asserted-by":"publisher","first-page":"5124","DOI":"10.1038\/s41467-022-32787-y","volume":"13","author":"L Ding","year":"2022","unstructured":"Ding L, Fu Y, Zhu N, Zhao M, Ding Z, Zhang X, Song Y, Jing Y, Zhang Q, Chen S, et al. 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