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There are several clinical instances that SDF application might precede the placement of direct tooth-colored restorations. On the other hand, SDF stains demineralized\/carious dental tissues black, which might affect the esthetic outcomes of such restorations. Color is a key parameter of esthetics in dentistry. Therefore, this study aims to systematically review dental literature on color\/color change of tooth-colored restorations placed following the application of SDF on dentine.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Comprehensive search of PubMed, Embase, Scopus and ISI Web of Science databases (until August 2023) as well as reference lists of retrieved studies was performed. In vitro studies reported color or color change of tooth-colored restorative materials applied on SDF-treated dentine were included. Methodological quality assessment was performed using RoBDEMAT tool. Pooled weighted mean difference (WMD) and 95% confidence interval (95% CI) was calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eleven studies\/reports with a total of 394 tooth-colored restorations placed following a) no SDF (control) or b) SDF with\/without potassium iodide (KI)\/glutathione dentine pre-treatments were included. Color change was quantified using \u2206E formulas in most reports. The pooled findings for the comparison of resin-based composite (RBC) restorations with and without prior 38% SDF\u2009+\u2009KI application revealed no statistically significant differences in \u2206E values at short- and long-term evaluations (~\u200914 days: WMD: -0.56, 95% CI: -2.09 to 0.96; I<jats:sup>2<\/jats:sup>: 89.6%, and\u2009~\u200960 days: WMD: 0.11; 95% CI: -1.51 to 1.72; I<jats:sup>2<\/jats:sup>: 76.9%). No studies provided sufficient information for all the items in the risk of bias tool (moderate to low quality).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The limited evidence suggested comparable color changes of RBC restorations with and without 38% SDF\u2009+\u2009KI pre-treatment up to 60 days. The included studies lacked uniformity in methodology and reported outcomes. Further studies are imperative to draw more definite conclusions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Protocol registration<\/jats:title>\n                <jats:p>The protocol of this systematic review was registered in PROSPERO database under number CRD42023485083.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04487-0","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T06:01:55Z","timestamp":1719468115000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Color change of tooth-colored restorative materials bonded to silver diamine fluoride-treated dentine: a systematic review"],"prefix":"10.1186","volume":"24","author":[{"given":"Sedigheh","family":"Sabbagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Movahhed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroash","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homeira","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"4487_CR1","volume-title":"Global oral health status report: towards universal health coverage for oral health by 2030","author":"World Health Organization","year":"2022","unstructured":"World Health Organization. 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