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Limited data are available regarding the expression of miRNA-146a and miR-NA-155 in diseased human peri-implant tissue. Therefore, the objective of this study was to explore the expression of miRNA-146a and miRNA-155 in human gingival peri-implant tissue affected by peri-implantitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>After recording the clinical parameters, human peri-implant pocket tissues were harvested from sites diagnosed with peri-implantitis (<jats:italic>n<\/jats:italic>\u2009=\u200915 cases) in addition to healthy peri-implant sulcus tissues (<jats:italic>n<\/jats:italic>\u2009=\u200915 controls). The levels of miRNA-146a and miRNA-155 were assessed using real-time qPCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Cases exhibited a significantly higher mean expression of miRNA-155 (5.2-fold increase) and miRNA-146a (2.8-fold increase) than controls. MiRNA-155 and miRNA-146a demonstrated an appropriate sensitivity (87.5% and 87.5%, respectively) and specificity (73.3% and 66.7%, respectively) in discriminating cases from controls. A moderate correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.544, <jats:italic>p<\/jats:italic>\u2009=\u20090.029) was found between miRNA-155 and miRNA-146a levels in the case group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The expressions of miRNA-146a and miR-NA-155 are different between healthy and peri-implantitis affected tissues. Both miRNAs might potentially able to discriminate healthy from peri-implantitis affected tissues.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04579-x","type":"journal-article","created":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T03:29:26Z","timestamp":1722137366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study"],"prefix":"10.1186","volume":"24","author":[{"given":"Munir Nasr","family":"Hamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder Raad","family":"Abdulbaqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"4579_CR1","doi-asserted-by":"publisher","first-page":"S313","DOI":"10.1002\/JPER.17-0739","volume":"89","author":"T Berglundh","year":"2018","unstructured":"Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, Chen S, Cochran D, Derks J, Figuero E. 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