{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:27:41Z","timestamp":1723595261655},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ectrodactyly-ectodermal dysplasia-cleft lip\/palate (EEC) syndrome mainly affects ectodermal and mesodermal tissues. It is usually manifested as split hands and feet, ectodermal dysplasia, and orofacial clefting, along with other signs and symptoms. A multidisciplinary approach to treatment is required, in which dentists play an important role in identifying and treating various oral conditions that may be genetically linked to or may be the result of EEC syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>The present case describes the oral condition of a young child suffering from EEC syndrome and presenting with peripheral giant cell granuloma (PGCG) in the mandibular anterior region. After obtaining a thorough medical and family history and a clinical examination, the lesion was surgically excised under local anesthesia. The patient was followed up at periodic intervals for the next twenty four months, during which no recurrence of the lesion was observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This report highlights the role of a dentist in the management of the oral conditions of patients suffering from EEC syndrome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04585-z","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T03:43:45Z","timestamp":1723520625000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral giant cell granuloma in a child with ectrodactyly-ectodermal dysplasia-cleft lip\/palate syndrome: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Aman","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay Kumar","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sannu","family":"Sonal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishali","family":"Bhati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"4585_CR1","doi-asserted-by":"publisher","first-page":"1002089","DOI":"10.3389\/fgene.2022.1002089","volume":"13","author":"H Biwei","year":"2022","unstructured":"Biwei H, Min S, Yanlin W, Xinrong Z, Li G, Renyi H, Jinling S, Shan W, Yi W, Weiwei C. Case report: prenatal diagnosis of Ectrodactyly\u2013ectodermal dysplasia\u2013cleft syndrome (EEC) in a fetus with cleft lip and polycystic kidney. Front Genet 2022 13:1002089. https:\/\/doi.org\/10.3389\/fgene.2022.1002089.","journal-title":"Front Genet"},{"key":"4585_CR2","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1136\/jmg.32.9.716","volume":"32","author":"PW Buss","year":"1995","unstructured":"Buss PW, Hughes HE, Clarke A. Twenty-four cases of the EEC syndrome: clinical presentation and management. J Med Genet. 1995;32:716\u201323. https:\/\/doi.org\/10.1136\/jmg.32.9.716.","journal-title":"J Med Genet"},{"key":"4585_CR3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/00019605-199604000-00003","volume":"5","author":"NM Roelfsema","year":"1996","unstructured":"Roelfsema NM, Cobben JM. The EEC syndrome: a literature study. Clin Dysmorphol. 1996;5:115\u201327. https:\/\/doi.org\/10.1097\/00019605-199604000-00003.","journal-title":"Clin Dysmorphol"},{"key":"4585_CR4","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1001\/archpedi.1970.02100070104016","volume":"120","author":"RA R\u00fcdiger","year":"1970","unstructured":"R\u00fcdiger RA, Haase W, Passarge E. Association of ectrodactyly, ectodermal dysplasia, and cleft lip-palate. Am J Dis Child. 1970;120:160\u20133. https:\/\/doi.org\/10.1001\/archpedi.1970.02100070104016.","journal-title":"Am J Dis Child"},{"key":"4585_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fped.2015.00051","volume":"3","author":"D Sharma","year":"2015","unstructured":"Sharma D, Kumar C, Bhalerao S, Pandita A, Shastri S, Sharma P, Ectrodactyly. Ectodermal dysplasia, cleft lip, and Palate (EEC Syndrome) with tetralogy of Fallot: a very rare combination. Front Pediatr. 2015;3:51. https:\/\/doi.org\/10.3389\/fped.2015.00051.","journal-title":"Front Pediatr"},{"key":"4585_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1136\/jmg.13.4.281","volume":"13","author":"VB Penchaszadeh","year":"1976","unstructured":"Penchaszadeh VB, de Negrotti TC. Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: dominant inheritance and variable expression. J Med Genet. 1976;13:281\u20134. https:\/\/doi.org\/10.1136\/jmg.13.4.281.","journal-title":"J Med Genet"},{"issue":"1","key":"4585_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1177\/1753193418807375","volume":"44","author":"S Guero","year":"2019","unstructured":"Guero S, Holder-Espinasse M. Insights into the pathogenesis and treatment of split\/hand foot malformation (cleft hand\/foot). J Hand Surg (European Volume). 2019;44(1):80\u20137. https:\/\/doi.org\/10.1177\/1753193418807375.","journal-title":"J Hand Surg (European Volume)"},{"key":"4585_CR8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s12105-019-01118-x","volume":"14","author":"SR Nagar","year":"2020","unstructured":"Nagar SR, Bansal S, Jashnani K, Sinha A, Desai RS. A comparative analysis of p63 expression in Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). Head Neck Pathol. 2020;14:733\u201341. https:\/\/doi.org\/10.1007\/s12105-019-01118-x.","journal-title":"Head Neck Pathol"},{"issue":"1","key":"4585_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.5281\/zenodo.7925739","volume":"42","author":"JO Guazhco","year":"2023","unstructured":"Guazhco JO, Idrovo PP, Moya JV, Guti\u00e9rrez MZ, Vaca R, et al. Surgical treatment of peripheral giant cell granuloma: a case report. Arch Venezolanos De Farmacologia Y Terap\u00e9utica. 2023;42(1):18\u201321. https:\/\/doi.org\/10.5281\/zenodo.7925739.","journal-title":"Arch Venezolanos De Farmacologia Y Terap\u00e9utica"},{"issue":"1","key":"4585_CR10","first-page":"S16","volume":"18","author":"GO Oboli","year":"2020","unstructured":"Oboli GO, Chukwuma DI, Fagbule OF, Abe EO, Adisa AO. Molecular genetics of cleft lip and palate: a review. Annals Ib Postgrad Med. 2020;18(1):S16\u201321. PMID: 33071691.","journal-title":"Annals Ib Postgrad Med"},{"key":"4585_CR11","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1046\/j.1468-3083.2003.00792_7.x","volume":"17","author":"R Glorio","year":"2003","unstructured":"Glorio R, Haas R, Jaimovich L. Ectrodactyly, ectodermal dysplasia and clefting (EEC) syndrome. J Eur Acad Dermatol Venereol. 2003;17:356\u20138. https:\/\/doi.org\/10.1046\/j.1468-3083.2003.00792_7.x.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"4585_CR12","first-page":"459","volume":"7","author":"S Gupta","year":"2017","unstructured":"Gupta S, Mittal S, Tewari S, Nandal S. Ectrodactyly, ectodermal dysplasia, and cleft lip\/palate syndrome: a case report. Int J Health Sci Res. 2017;7(4):459\u201362.","journal-title":"Int J Health Sci Res"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-04585-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-024-04585-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-04585-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T15:07:11Z","timestamp":1723561631000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-024-04585-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4585"],"URL":"https:\/\/doi.org\/10.1186\/s12903-024-04585-z","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"26 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"<b>Written informed consent<\/b> was obtained from the patient and his parents for inclusion of the patient\u2019s data (personal or clinical) in the manuscript and for subsequent publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"936"}}