{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:29:14Z","timestamp":1784654954078,"version":"3.55.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Hebei Provincial Administration of Traditional Chinese Medicine","award":["2024054"],"award-info":[{"award-number":["2024054"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-024-04740-6","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:27:38Z","timestamp":1724434058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of the mechanism of baicalein in the treatment of periodontitis based on network pharmacology, molecular docking and experimental validation"],"prefix":"10.1186","volume":"24","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengdi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"issue":"1","key":"4740_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J. Periodontitis: facts, fallacies and the future. Periodontology 2000. 2017;75(1):7\u201323.","journal-title":"Periodontology 2000"},{"issue":"10","key":"4740_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"J Potempa","year":"2017","unstructured":"Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(10):606\u201320.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"4740_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/prd.12387","volume":"87","author":"R Kuraji","year":"2021","unstructured":"Kuraji R, Sekino S, Kapila Y, et al. Periodontal disease\u2013related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral\u2010liver axis. Periodontol 2000. 2021;87(1):204\u201340.","journal-title":"Periodontol 2000"},{"issue":"1","key":"4740_CR4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/prd.12304","volume":"83","author":"HA Schenkein","year":"2020","unstructured":"Schenkein HA, Papapanou PN, Genco R, et al. Mechanisms underlying the association between periodontitis and atherosclerotic disease. Periodontol 2000. 2020;83(1):90\u2013106.","journal-title":"Periodontol 2000"},{"issue":"1","key":"4740_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12326","volume":"83","author":"S Jepsen","year":"2020","unstructured":"Jepsen S, Suvan J, Deschner J. The association of periodontal diseases with metabolic syndrome and obesity. Periodontol 2000. 2020;83(1):125\u201353.","journal-title":"Periodontol 2000"},{"issue":"2","key":"4740_CR6","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/WCO.0000000000000797","volume":"33","author":"M Sadrameli","year":"2020","unstructured":"Sadrameli M, Bathini P, Alberi L. Linking mechanisms of periodontitis to Alzheimer\u2019s disease. Curr Opin Neurol. 2020;33(2):230\u20138.","journal-title":"Curr Opin Neurol"},{"key":"4740_CR7","unstructured":"Chen Haiyan, Wang Liujing. Exploring a new model of oral health management based on TCM theory. J Chin Med Manage. 2022;30(10):220\u20132."},{"key":"4740_CR8","doi-asserted-by":"publisher","first-page":"118183","DOI":"10.1016\/j.lfs.2020.118183","volume":"259","author":"HS Tuli","year":"2020","unstructured":"Tuli HS, Aggarwal V, Kaur J, et al. Baicalein: A metabolite with promising antineoplastic activity. Life Sci. 2020;259:118183.","journal-title":"Life Sci"},{"issue":"11","key":"4740_CR9","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.1111\/jcmm.16538","volume":"25","author":"B Li","year":"2021","unstructured":"Li B, Chen K, Qian N, et al. Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation. J Cell Mol Med. 2021;25(11):5283\u201394.","journal-title":"J Cell Mol Med"},{"key":"4740_CR10","unstructured":"Bi L, Liu H, Wu R. The effect of baicalin on osteoclast formation and alveolar bone resorption in periodontal disease rats through the Nrf2\/NF-\u03baB\/NFATc1 signaling pathway. J Guangxi Med. 2021;43(05):600\u20136."},{"issue":"7","key":"4740_CR11","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1142\/S0192415X16500816","volume":"44","author":"SI Lee","year":"2016","unstructured":"Lee SI, Kim SY, Park KR, et al. Baicalein promotes angiogenesis and odontoblastic differentiation via the BMP and Wnt pathways in human dental pulp cells. Am J Chin Med. 2016;44(7):1457\u201372.","journal-title":"Am J Chin Med"},{"key":"4740_CR12","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.archoralbio.2017.01.019","volume":"78","author":"L-J Chen","year":"2017","unstructured":"Chen L-J, Hu B-B, Shi X-L, et al. Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt\/\u03b2-catenin signaling pathway. Arch Oral Biol. 2017;78:100\u20138.","journal-title":"Arch Oral Biol"},{"issue":"11","key":"4740_CR13","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682\u201390.","journal-title":"Nat Chem Biol"},{"issue":"5","key":"4740_CR14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2174\/1389450119666181022153016","volume":"20","author":"S Saikia","year":"2019","unstructured":"Saikia S, Bordoloi M. Molecular docking: challenges, advances and its use in drug discovery perspective. Curr Drug Targets. 2019;20(5):501\u201321.","journal-title":"Curr Drug Targets"},{"issue":"1","key":"4740_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"J Ru","year":"2014","unstructured":"Ru J, Li P, Wang J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014;6(1):13.","journal-title":"J Cheminform"},{"issue":"W1","key":"4740_CR16","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina A, Michielin O, Zoete V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 2019;47(W1):W357\u201364.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4740_CR17","doi-asserted-by":"publisher","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","volume":"45","author":"The UniProt Consortium","year":"2017","unstructured":"The UniProt Consortium. UniProt: the universal protein knowledgebase. Nucleic Acids Res. 2017;45(D1):D158\u201369.","journal-title":"Nucleic Acids Res"},{"key":"4740_CR18","doi-asserted-by":"publisher","first-page":"baq020","DOI":"10.1093\/database\/baq020","volume":"2010","author":"M Safran","year":"2010","unstructured":"Safran M, Dalah I, Alexander J, et al. GeneCards Version 3: the human gene integrator. Database (Oxford). 2010;2010:baq020.","journal-title":"Database (Oxford)"},{"issue":"D1","key":"4740_CR19","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, Feunang YD, Guo AC, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46(D1):D1074\u201382.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4740_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","volume":"15","author":"P Bardou","year":"2014","unstructured":"Bardou P, Mariette J, Escudi\u00e9 F, et al. jvenn: an interactive Venn diagram viewer. BMC Bioinformatics. 2014;15(1):293.","journal-title":"BMC Bioinformatics"},{"issue":"D1","key":"4740_CR21","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607\u201313.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"4740_CR22","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, et al. Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks. Genome Res. 2003;13(11):2498\u2013504.","journal-title":"Genome Res"},{"issue":"1","key":"4740_CR23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2105-4-2","volume":"4","author":"GD Bader","year":"2003","unstructured":"Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 2003;4(1):2.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"4740_CR24","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.","journal-title":"Nat Commun"},{"key":"4740_CR25","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/978-1-4939-6952-4_20","volume":"1598","author":"N El-Hachem","year":"2017","unstructured":"El-Hachem N, Haibe-Kains B, Khalil A, et al. AutoDock and AutoDockTools for Protein-Ligand Docking: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) as a Case Study. Methods Mol Biol. 2017;1598:391\u2013403.","journal-title":"Methods Mol Biol"},{"issue":"1","key":"4740_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/pro.3730","volume":"29","author":"DS Goodsell","year":"2020","unstructured":"Goodsell DS, Zardecki C, Di Costanzo L, et al. RCSB protein data bank: enabling biomedical research and drug discovery. Protein Sci. 2020;29(1):52\u201365.","journal-title":"Protein Sci"},{"key":"4740_CR27","doi-asserted-by":"crossref","unstructured":"Shah AP, Parmar G, Shah U, et al. Virtual screening, molecular docking studies and DFT calculations of novel anticancer flavonoids as potential VEGFR-2 inhibitors. Chem Afr. 2023;(6):1847\u201361.","DOI":"10.1007\/s42250-023-00611-9"},{"issue":"8","key":"4740_CR28","doi-asserted-by":"publisher","first-page":"e21931","DOI":"10.1371\/journal.pone.0021931","volume":"6","author":"EH Baugh","year":"2011","unstructured":"Baugh EH, Lyskov S, Weitzner BD, et al. Real-Time PyMOL Visualization for Rosetta and PyRosetta. PLoS ONE. 2011;6(8):e21931.","journal-title":"PLoS ONE"},{"key":"4740_CR29","first-page":"102","volume":"35","author":"JB Xu","year":"2007","unstructured":"Xu JB, Hao HQ. Analysis of clinical efficacy of Chinese medicine in the treatment of periodontitis. Chin Med Herald. 2007;35:102\u20133.","journal-title":"Chin Med Herald"},{"key":"4740_CR30","unstructured":"Xing X. Meta-analysis on the treatment of periodontitis with Chinese medicine in the past 30 years. J Gansu Coll Tradit Chin Med. 2014."},{"key":"4740_CR31","unstructured":"Zhang W, Wang Y. Observation on the efficacy of periodontal septic drink combined with cavity cure jie in the treatment of acute periodontitis. J Modern Tradit Chin West Med. 2016;25(30):3387\u20139."},{"key":"4740_CR32","doi-asserted-by":"crossref","unstructured":"Lin C, Xu H Y. Efficacy of combining minocycline hydrochloride with Jia Wei Qing Gastric Tang in the treatment of chronic periodontitis and the effect on IL-1\u03b2, IL-6 and PGE_2 levels in gingival sulcus fluid. Chin J Trad Chin Med. 2021;39(10):199\u2013203.","DOI":"10.1142\/S0192415X21500117"},{"key":"4740_CR33","unstructured":"Luo F, Yu Y, Xiao L, et al. A review of the effects of the main chemical components of Scutellaria baicalensis on oral diseases. World Sci Technol Modern Chin Med. 2021;23(09):3289\u201397."},{"key":"4740_CR34","unstructured":"Zhang Y. Observation on the effect of compound baicalin gargle for the prevention and treatment of stomatitis in chemotherapy patients. Chin Nat Health Med. 2012;24(12):1463\u20134."},{"key":"4740_CR35","unstructured":"Yang L, Zhang JF, Li B et al. Effect of Shuanghuanglian injection on the efficacy of root canal disinfection and periapical tissue healing in patients with chronic periapical inflammation. J Modern Tradit Chin West Med. 2021;30(03):301\u20134."},{"key":"4740_CR36","unstructured":"Xu Y. The basic and applied study of Shuanghuangbu in the treatment of periodontitis. Hebei Medical University; 2004. PhD dissertation."},{"key":"4740_CR37","unstructured":"Yang L, Ji J, Fan Y, et al. The effect of Shuanghuanglian toothpaste on the control of plaque and gingivitis. Beijing Stomatol. 2014;22(03):159\u201361."},{"key":"4740_CR38","unstructured":"Zhu Y, Yang Q, Zhang S, et al. Research progress on pharmacological effects and mechanisms of baicalin and baicalein. Shi Zhen Guoyi Guoyao. 2020;31(04):921\u20135."},{"issue":"8","key":"4740_CR39","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1021\/acs.jcim.8b00312","volume":"58","author":"T Gaillard","year":"2018","unstructured":"Gaillard T. Evaluation of AutoDock and AutoDock Vina on the CASF-2013 Benchmark. J Chem Inf Model. 2018;58(8):1697\u2013706.","journal-title":"J Chem Inf Model"},{"issue":"1","key":"4740_CR40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5051\/jpis.2013.43.1.24","volume":"43","author":"K-A Kim","year":"2013","unstructured":"Kim K-A, Chung S-B, Hawng E-Y, et al. Correlation of expression and activity of matrix metalloproteinase-9 and -2 in human gingival cells of periodontitis patients. J Periodontal Implant Sci. 2013;43(1):24.","journal-title":"J Periodontal Implant Sci"},{"issue":"3","key":"4740_CR41","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/jcm10030379","volume":"10","author":"I Luchian","year":"2021","unstructured":"Luchian I, Moscalu M, Goriuc A, et al. Using salivary MMP-9 to successfully quantify periodontal inflammation during orthodontic treatment. J Clin Med. 2021;10(3):379.","journal-title":"J Clin Med"},{"key":"4740_CR42","unstructured":"Chen Y, Gou J. The relationship between the amount of MMP-2,9 in gingival crevicular fluid and periodontal disease journal of Xi'an Jiaotong University. J Xi'an Jiaotong Univ Med. 2005;(03):294\u20136."},{"issue":"5","key":"4740_CR43","doi-asserted-by":"publisher","first-page":"jcs236588","DOI":"10.1242\/jcs.236588","volume":"133","author":"J Bi","year":"2020","unstructured":"Bi J, Koivisto L, Dai J, et al. Epidermal growth factor receptor signaling suppresses \u03b1v\u03b26 integrin and promotes periodontal inflammation and bone loss. J Cell Sci. 2020;133(5):jcs236588.","journal-title":"J Cell Sci."},{"issue":"9","key":"4740_CR44","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/JPER.18-0026","volume":"89","author":"J Liu","year":"2018","unstructured":"Liu J, Zeng J, Wang X, et al. P53 mediates lipopolysaccharide-induced inflammation in human gingival fibroblasts. J Periodontol. 2018;89(9):1142\u201351.","journal-title":"J Periodontol"},{"issue":"19","key":"4740_CR45","doi-asserted-by":"publisher","first-page":"10701","DOI":"10.3390\/ijms221910701","volume":"22","author":"J Korbecki","year":"2021","unstructured":"Korbecki J, Simi\u0144ska D, G\u0105ssowska-Dobrowolska M, et al. Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-\u03baB Activation: A Review of the Molecular Mechanisms. Int J Mol Sci. 2021;22(19):10701.","journal-title":"Int J Mol Sci"},{"key":"4740_CR46","doi-asserted-by":"publisher","first-page":"107901","DOI":"10.1016\/j.intimp.2021.107901","volume":"99","author":"M Chen","year":"2021","unstructured":"Chen M, Wang Y, Sun B, et al. HIF-1\u03b1 activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization. Int Immunopharmacol. 2021;99:107901.","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"4740_CR47","doi-asserted-by":"publisher","first-page":"21182","DOI":"10.1002\/jcp.28721","volume":"234","author":"J Zhu","year":"2019","unstructured":"Zhu J, Tang Y, Wu Q, et al. HIF-1\u03b1 facilitates osteocyte-mediated osteoclastogenesis by activating JAK2\/STAT3 pathway in vitro. J Cell Physiol. 2019;234(11):21182\u201392.","journal-title":"J Cell Physiol"},{"issue":"S1","key":"4740_CR48","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/BF03026317","volume":"23","author":"BF Boyce","year":"2005","unstructured":"Boyce BF, Yamashita T, Yao Z, et al. Roles for NF-\u03baB and c-Fos in osteoclasts. J Bone Miner Metab. 2005;23(S1):11\u20135.","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"4740_CR49","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1177\/0022034514567197","volume":"94","author":"S Sen","year":"2015","unstructured":"Sen S, Diercke K, Zingler S, et al. Compression Induces Ephrin-A2 in PDL Fibroblasts via c-fos. J Dent Res. 2015;94(3):464\u201372.","journal-title":"J Dent Res"},{"key":"4740_CR50","first-page":"1","volume":"2012","author":"S-W Choi","year":"2012","unstructured":"Choi S-W, Son Y-J, Yun J-M, et al. Fisetin inhibits osteoclast differentiation via downregulation of p38 and c-Fos-NFATc1 Signaling Pathways. Evid Based Complement Alternat Med. 2012;2012:1\u20139.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"4740_CR51","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10753-018-00951-6","volume":"42","author":"M Du","year":"2019","unstructured":"Du M, Wang Y, Liu Z, et al. Effects of IL-1\u03b2 on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen. Inflammation. 2019;42(2):413\u201325.","journal-title":"Inflammation"},{"issue":"11","key":"4740_CR52","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.3390\/ijms19113634","volume":"19","author":"X Cui","year":"2018","unstructured":"Cui X, Qian D-W, Jiang S, et al. Scutellariae radix and coptidis rhizoma improve glucose and lipid metabolism in T2DM Rats via regulation of the metabolic profiling and MAPK\/PI3K\/Akt signaling pathway. Int J Mol Sci. 2018;19(11):3634.","journal-title":"Int J Mol Sci"},{"key":"4740_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/6168340","volume":"2019","author":"M-X Duan","year":"2019","unstructured":"Duan M-X, Zhou H, Wu Q-Q, et al. Andrographolide protects against hg-induced inflammation, apoptosis, migration, and impairment of angiogenesis via PI3K\/AKT-eNOS signalling in HUVECs. Mediators Inflamm. 2019;2019:1\u201315.","journal-title":"Mediators Inflamm"},{"issue":"10","key":"4740_CR54","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.4049\/jimmunol.2200727","volume":"211","author":"J Zhou","year":"2023","unstructured":"Zhou J, Shi P, Ma R, et al. Notopterol Inhibits the NF-\u03baB Pathway and Activates the PI3K\/Akt\/Nrf2 Pathway in Periodontal Tissue. J Immunol. 2023;211(10):1516\u201325.","journal-title":"J Immunol"},{"issue":"6","key":"4740_CR55","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1177\/1535370220903463","volume":"245","author":"B Zhao","year":"2020","unstructured":"Zhao B, Xiong Y, Zhang Y, et al. Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K\/AKT\/mTOR signaling pathway. Exp Biol Med (Maywood). 2020;245(6):552\u201361.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1\u20132","key":"4740_CR56","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.imlet.2011.05.007","volume":"139","author":"SY Park","year":"2011","unstructured":"Park SY, Park DJ, Kim YH, et al. Upregulation of heme oxygenase-1 via PI3K\/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages. Immunol Lett. 2011;139(1\u20132):93\u2013101.","journal-title":"Immunol Lett"},{"issue":"12","key":"4740_CR57","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1161\/CIRCRESAHA.107.153346","volume":"101","author":"M Bosch-Marce","year":"2007","unstructured":"Bosch-Marce M, Okuyama H, Wesley JB, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after Limb Ischemia. Circ Res. 2007;101(12):1310\u20138.","journal-title":"Circ Res"},{"key":"4740_CR58","doi-asserted-by":"crossref","unstructured":"Simon MC. Coming up for air: HIF-1 and mitochondrial oxygen consumption. Cell Metab. 2006;3(3):150\u20131.","DOI":"10.1016\/j.cmet.2006.02.007"},{"issue":"3","key":"4740_CR59","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1365-2184.2012.00810.x","volume":"45","author":"ZC Song","year":"2012","unstructured":"Song ZC, Zhou W, Shu R, et al. Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF -1\u03b1 pathway. Cell Prolif. 2012;45(3):239\u201348.","journal-title":"Cell Prolif"},{"issue":"2","key":"4740_CR60","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/hep.30215","volume":"69","author":"X Wang","year":"2019","unstructured":"Wang X, de Carvalho RM, Iracheta-Vellve A, et al. Macrophage-specific hypoxia-inducible factor-1\u03b1 contributes to impaired autophagic flux in nonalcoholic steatohepatitis. Hepatology. 2019;69(2):545\u201363.","journal-title":"Hepatology"},{"issue":"6","key":"4740_CR61","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1002\/jcb.25672","volume":"118","author":"L Wu","year":"2017","unstructured":"Wu L, Guo Q, Yang J, et al. Tumor necrosis factor alpha promotes osteoclast formation via PI3K\/Akt pathway-mediated blimp1 expression upregulation. J Cell Biochem. 2017;118(6):1308\u201315.","journal-title":"J Cell Biochem"},{"key":"4740_CR62","doi-asserted-by":"crossref","unstructured":"Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 2014;6:13.","DOI":"10.12703\/P6-13"},{"issue":"2","key":"4740_CR63","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.cellsig.2013.11.004","volume":"26","author":"D Zhou","year":"2014","unstructured":"Zhou D, Huang C, Lin Z, et al. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal. 2014;26(2):192\u20137.","journal-title":"Cell Signal"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-04740-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-024-04740-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-04740-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:28:44Z","timestamp":1724434124000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-024-04740-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4740"],"URL":"https:\/\/doi.org\/10.1186\/s12903-024-04740-6","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"13 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consent to publication of the present manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"987"}}