{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:25:58Z","timestamp":1759227958749,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Oral lichen planus is a well-known chronic inflammatory mucocutaneous disorder, which has clinical and histological presentation that mimics oral lichenoid reaction. According to the fifth edition of WHO, both conditions are considered as oral potentially malignant disorders. Recent studies on oral potential disorders documented deregulation of some signaling molecules related to the Wnt\/\u03b2-catenin pathway. Therefore this study aimed to compare the immune expression of \u03b2-catenin &amp; CD163 in dysplastic \/non-dysplastic cases of Oral lichen planus &amp; oral lichenoid lesion. In addition, a statistical correlation between both immune markers was done regardless of the type of the study group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Four study groups were designated as 2 groups of Oral lichen planus (one dysplastic &amp; one non \u2013dysplastic) and the other 2 groups were oral lichenoid lesions (one dysplastic &amp; one non \u2013dysplastic). Ten cases in each group were collected and investigated by immunohistochemistry. The area percent of beta catenin and also counting of m2 macrophages expressing\u2009+\u2009CD163 marker was calculated in the study groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The Statistical analysis highlighted a statistically significant difference between the studied groups. Moreover, Pearson correlation test reported a significant moderate positive correlation between beta catenin &amp; CD163 expression in the studied cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our findings supported new perceptions of the mechanism by which tumor associated macrophage specific \u03b2-catenin signaling promotes the aggressive behavior of oral potential malignant disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Evidence of the relationship between beta catenin and M2 macrophages (+\u2009CD163) may enhance the development of macrophage-based strategies for treatment and improve the prognosis of such cases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04822-5","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T15:39:43Z","timestamp":1727365183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative immunohistochemical expression of Beta catenin and CD163 between dysplastic \/ non-dysplastic oral lichen planus and lichenoid lesions (EX-VIVO STUDY)"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-6266","authenticated-orcid":false,"given":"Heba Ahmed","family":"Saleh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-2227","authenticated-orcid":false,"given":"Ghada","family":"Nabil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-6796","authenticated-orcid":false,"given":"Sarah Ahmed Mohammed Mahmoud","family":"Badawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"issue":"4","key":"4822_CR1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.30476\/DENTJODS.2021.91356.1572","volume":"23","author":"S - Kakoei","year":"2022","unstructured":"- Kakoei S, Torabi Parizi M, Rad M, Karbasi N, Mafi S. Retrospective study of oral Lichen Planus and oral lichenoid lesions: Clinical Profile and Malignant Transformation. J Dent. 2022;23(4):452\u20138. https:\/\/doi.org\/10.30476\/DENTJODS.2021.91356.1572.","journal-title":"J Dent"},{"issue":"4","key":"4822_CR2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.oooo.2020.07.002","volume":"130","author":"G - Guan","year":"2020","unstructured":"- Guan G, Mei L, Polonowita A, Hussaini H, Seo B, Rich AM. Malignant transformation in oral lichen planus and lichenoid lesions: a 14-year longitudinal retrospective cohort study of 829 patients in New Zealand. 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The role of CD68\u2009+\u2009and CD163\u2009+\u2009macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions. Immunobiol. 2021;226(3):152072\u201381. https:\/\/doi.org\/10.1016\/j.imbio.2021.152072.","journal-title":"Immunobiol"},{"key":"4822_CR7","doi-asserted-by":"publisher","unstructured":"- Sauerbrei W, Taube SE, McShane LM, Cavenagh MM, Altman DG. (2018). Reporting recommendations for tumor marker prognostic studies (REMARK): an abridged explanation and elaboration. JNCI: Journal of the National Cancer Institute, 1;110(8):803\u2009\u2013\u200911. https:\/\/doi.org\/10.1093\/jnci\/djy088","DOI":"10.1093\/jnci\/djy088"},{"key":"4822_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41415-024-7063-y","volume":"236","author":"R - Binnie","year":"2024","unstructured":"- Binnie R, Dobson M, Chrystal A, et al. Oral lichen planus and lichenoid lesions - challenges and pitfalls for the general dental practitioner. 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This study was registered with no. (19 12 22) after reviewing the protocol.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This is not applicable in our study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The informed consent to participate was waived by Ethical Committee of Faculty of Dentistry, Cairo University for this study type as we used archival blocks of processed tissues (oral biopsies) according to regulations of this ethical committee.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"1122"}}